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Fabrication and characterization of PVA/Gum tragacanth/PCL hybrid nanofibrous scaffolds for skin substitutes.
Int J Biol Macromol 2017; 94(Pt A):679-690IJ

Abstract

In this work three dimensional biodegradable nanofiberous scaffolds containing poly(ε-caprolactone) (PCL), poly(vinyl alcohol) (PVA) and gum tragacanth (GT) were successfully fabricated through two nozzles electrospinning process. For this purpose, PVA/GT blend (Blend: B) solution (60:40wt%) was injected from one syringe and poly(ε-caprolactone) solution from the other one. Presence of PVA and PCL in the formulation improved the electrospinning process of GT solution and mechanical properties of the fabricated nanofibers. Scanning electron microscopy (SEM) results showed uniform PVA/GT-PCL blend-hybrid (Blend-Hybrid: B-H) nanofibers with the diameter ranging about 132±27nm. Hybrid nanofibers were evaluated by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) tests. The antibacterial activities of the PVA/GT-PCL (B-H) nanofibers were conducted against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus and results indicated that the hybrid nanofibers were 95.19% antibacterial against S. aureus bacterium. NIH 3T3 fibroblast cells growth and MTT assay were carried out on the scaffolds. Hydrophilicity nature, favorable mechanical properties of the fabricated hybrid nanofibers, along with their structure in biological media, biocompatibility, as well as antibacterial property indicate scaffolds prepared are suitable for tissue engineering.

Authors+Show Affiliations

Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran.Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran. Electronic address: hajirb@aut.ac.ir.Department of Textile Engineering, Faculty of Engineering, University of Bonab, Bonab, Iran.School of Advanced Medical Technologies, Tissue Engineering Department, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27777080

Citation

Zarekhalili, Zahra, et al. "Fabrication and Characterization of PVA/Gum tragacanth/PCL Hybrid Nanofibrous Scaffolds for Skin Substitutes." International Journal of Biological Macromolecules, vol. 94, no. Pt A, 2017, pp. 679-690.
Zarekhalili Z, Bahrami SH, Ranjbar-Mohammadi M, et al. Fabrication and characterization of PVA/Gum tragacanth/PCL hybrid nanofibrous scaffolds for skin substitutes. Int J Biol Macromol. 2017;94(Pt A):679-690.
Zarekhalili, Z., Bahrami, S. H., Ranjbar-Mohammadi, M., & Milan, P. B. (2017). Fabrication and characterization of PVA/Gum tragacanth/PCL hybrid nanofibrous scaffolds for skin substitutes. International Journal of Biological Macromolecules, 94(Pt A), pp. 679-690. doi:10.1016/j.ijbiomac.2016.10.042.
Zarekhalili Z, et al. Fabrication and Characterization of PVA/Gum tragacanth/PCL Hybrid Nanofibrous Scaffolds for Skin Substitutes. Int J Biol Macromol. 2017;94(Pt A):679-690. PubMed PMID: 27777080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication and characterization of PVA/Gum tragacanth/PCL hybrid nanofibrous scaffolds for skin substitutes. AU - Zarekhalili,Zahra, AU - Bahrami,S Hajir, AU - Ranjbar-Mohammadi,M, AU - Milan,Peiman Brouki, Y1 - 2016/10/21/ PY - 2016/06/09/received PY - 2016/10/08/revised PY - 2016/10/14/accepted PY - 2016/10/30/pubmed PY - 2017/4/4/medline PY - 2016/10/30/entrez KW - Electrospinning KW - Gum tragacanth KW - Nanofibrous scaffold KW - Poly (vinyl alcohol) KW - Poly (ε-caprolactone) KW - Tissue engineering SP - 679 EP - 690 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 94 IS - Pt A N2 - In this work three dimensional biodegradable nanofiberous scaffolds containing poly(ε-caprolactone) (PCL), poly(vinyl alcohol) (PVA) and gum tragacanth (GT) were successfully fabricated through two nozzles electrospinning process. For this purpose, PVA/GT blend (Blend: B) solution (60:40wt%) was injected from one syringe and poly(ε-caprolactone) solution from the other one. Presence of PVA and PCL in the formulation improved the electrospinning process of GT solution and mechanical properties of the fabricated nanofibers. Scanning electron microscopy (SEM) results showed uniform PVA/GT-PCL blend-hybrid (Blend-Hybrid: B-H) nanofibers with the diameter ranging about 132±27nm. Hybrid nanofibers were evaluated by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) tests. The antibacterial activities of the PVA/GT-PCL (B-H) nanofibers were conducted against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus and results indicated that the hybrid nanofibers were 95.19% antibacterial against S. aureus bacterium. NIH 3T3 fibroblast cells growth and MTT assay were carried out on the scaffolds. Hydrophilicity nature, favorable mechanical properties of the fabricated hybrid nanofibers, along with their structure in biological media, biocompatibility, as well as antibacterial property indicate scaffolds prepared are suitable for tissue engineering. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/27777080/Fabrication_and_characterization_of_PVA/Gum_tragacanth/PCL_hybrid_nanofibrous_scaffolds_for_skin_substitutes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(16)32011-6 DB - PRIME DP - Unbound Medicine ER -