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Testicular feminization in a cat.
J Am Vet Med Assoc. 1989 Sep 01; 195(5):631-4.JA

Abstract

Testicular feminization, caused by an inherited defect of the androgen receptor, was diagnosed in a domestic cat. Individuals affected with this syndrome are genetic males that have testes but fail to undergo masculinization because the internal and external genitalia cannot respond to androgens. The affected cat had the external appearance of a sexually normal female, but during surgery for ovariohysterectomy, only 2 abdominal gonads were found. Müllerian (uterus) or wolffian (epididymides) derivatives were not present. Only testicular tissue was found in histologic sections of the gonad. A normal male chromosome constitution (38,XY) was found in karyotypes prepared from lymphocyte cultures. High affinity binding of dihydrotestosterone was undetectable in fibroblasts cultured from genital skin of the affected cat, indicating that the cytosolic androgen receptor was nonfunctional. Pedigree analysis indicates that this is an X-linked disorder in cats, as it is in other mammals. Accurate diagnosis and genetic counseling are advocated to reduce the prevalence of the disorder.

Authors+Show Affiliations

Section of Medical Genetics and National Referral Center--Animal Models of Human Genetic Disease, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2777713

Citation

Meyers-Wallen, V N., et al. "Testicular Feminization in a Cat." Journal of the American Veterinary Medical Association, vol. 195, no. 5, 1989, pp. 631-4.
Meyers-Wallen VN, Wilson JD, Griffin JE, et al. Testicular feminization in a cat. J Am Vet Med Assoc. 1989;195(5):631-4.
Meyers-Wallen, V. N., Wilson, J. D., Griffin, J. E., Fisher, S., Moorhead, P. H., Goldschmidt, M. H., Haskins, M. E., & Patterson, D. F. (1989). Testicular feminization in a cat. Journal of the American Veterinary Medical Association, 195(5), 631-4.
Meyers-Wallen VN, et al. Testicular Feminization in a Cat. J Am Vet Med Assoc. 1989 Sep 1;195(5):631-4. PubMed PMID: 2777713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testicular feminization in a cat. AU - Meyers-Wallen,V N, AU - Wilson,J D, AU - Griffin,J E, AU - Fisher,S, AU - Moorhead,P H, AU - Goldschmidt,M H, AU - Haskins,M E, AU - Patterson,D F, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 631 EP - 4 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 195 IS - 5 N2 - Testicular feminization, caused by an inherited defect of the androgen receptor, was diagnosed in a domestic cat. Individuals affected with this syndrome are genetic males that have testes but fail to undergo masculinization because the internal and external genitalia cannot respond to androgens. The affected cat had the external appearance of a sexually normal female, but during surgery for ovariohysterectomy, only 2 abdominal gonads were found. Müllerian (uterus) or wolffian (epididymides) derivatives were not present. Only testicular tissue was found in histologic sections of the gonad. A normal male chromosome constitution (38,XY) was found in karyotypes prepared from lymphocyte cultures. High affinity binding of dihydrotestosterone was undetectable in fibroblasts cultured from genital skin of the affected cat, indicating that the cytosolic androgen receptor was nonfunctional. Pedigree analysis indicates that this is an X-linked disorder in cats, as it is in other mammals. Accurate diagnosis and genetic counseling are advocated to reduce the prevalence of the disorder. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/2777713/Testicular_feminization_in_a_cat_ L2 - http://www.diseaseinfosearch.org/result/7031 DB - PRIME DP - Unbound Medicine ER -