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Vitamin D Status and Bone Mineral Density is Influenced by Vitamin D Supplementation and Vitamin K1 Intake in Adults with Diabetes and Chronic Kidney Disease.
Can J Diet Pract Res. 2017 03; 78(1):11-19.CJ

Abstract

PURPOSE

Patients with diabetes (DM) and chronic kidney disease (CKD) are at increased risk for suboptimal bone health. The study objective was to investigate the relationships between vitamin D (vitD), vitamin K1 (vitK1), and calcium intake with bone mineral density (BMD) and vitamin D status in an ambulatory population with DM and CKD.

METHODS

Adults (age 18-80 years; n = 62) with DM and CKD (stages 1-4) were recruited from the Northern Alberta Renal Program. Primary outcome variables included vitD, vitK1, and calcium intake; serum 25(OH)D, 1,25(OH)2D; and BMD as measured by dual X-ray absorptiometry. Statistical significance was determined at P < 0.05.

RESULTS

Participants met the estimated average requirement or adequate intake for vitD, vitK1, and calcium intake in 73% (n = 45), 66% (n = 39), and 52% (n = 31), respectively, with a combined intake of micronutrient supplementation and diet. Participants had serum 25(OH)D concentrations ≥75 nmol/L (n = 41), normal BMDs (n = 48), and 66% (n = 41/62) were taking vitD supplements (>1000 IU/D). BMD was positively influenced by serum 25(OH)D. However, serum 25(OH) ≥100 nmol/L was associated with lower BMD (absolute and T-scores) for whole-body and spine (P ≤ 0.05). VitK1 intake (≥200 μg/day) was associated with higher whole-body and femoral-neck BMDs (absoluteand T-scores; P ≤ 0.05).

CONCLUSION

VitD status and BMD in adults with DM and CKD was influenced by vitD supplementation and vitK1 intake.

Authors+Show Affiliations

a Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.b Divsion of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, AB. c Diabetic Nephropathy Prevention Clinic, Alberta Health Services, Edmonton, AB.a Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.d Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montreal, QC. e Département de Nutrition, Université de Montréal, Montreal, QC.d Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montreal, QC. e Département de Nutrition, Université de Montréal, Montreal, QC.f Northern Alberta Renal Program, Edmonton, AB. g Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB.a Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.a Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.a Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB. h Department of Pediatrics, University of Alberta, Edmonton, AB.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27779902

Citation

Hoffmann, Michelle R., et al. "Vitamin D Status and Bone Mineral Density Is Influenced By Vitamin D Supplementation and Vitamin K1 Intake in Adults With Diabetes and Chronic Kidney Disease." Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Dietetique : Une Publication Des Dietetistes Du Canada, vol. 78, no. 1, 2017, pp. 11-19.
Hoffmann MR, Senior PA, Jackson ST, et al. Vitamin D Status and Bone Mineral Density is Influenced by Vitamin D Supplementation and Vitamin K1 Intake in Adults with Diabetes and Chronic Kidney Disease. Can J Diet Pract Res. 2017;78(1):11-19.
Hoffmann, M. R., Senior, P. A., Jackson, S. T., Ferland, G., Presse, N., Jindal, K., Li, P., Alzaben, A. S., & Mager, D. R. (2017). Vitamin D Status and Bone Mineral Density is Influenced by Vitamin D Supplementation and Vitamin K1 Intake in Adults with Diabetes and Chronic Kidney Disease. Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Dietetique : Une Publication Des Dietetistes Du Canada, 78(1), 11-19. https://doi.org/10.3148/cjdpr-2016-023
Hoffmann MR, et al. Vitamin D Status and Bone Mineral Density Is Influenced By Vitamin D Supplementation and Vitamin K1 Intake in Adults With Diabetes and Chronic Kidney Disease. Can J Diet Pract Res. 2017;78(1):11-19. PubMed PMID: 27779902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Status and Bone Mineral Density is Influenced by Vitamin D Supplementation and Vitamin K1 Intake in Adults with Diabetes and Chronic Kidney Disease. AU - Hoffmann,Michelle R, AU - Senior,Peter A, AU - Jackson,Stephanie T, AU - Ferland,Guylaine, AU - Presse,Nancy, AU - Jindal,Kailash, AU - Li,Ping, AU - Alzaben,Abeer S, AU - Mager,Diana R, Y1 - 2016/10/25/ PY - 2016/10/26/pubmed PY - 2018/2/28/medline PY - 2016/10/26/entrez SP - 11 EP - 19 JF - Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada JO - Can J Diet Pract Res VL - 78 IS - 1 N2 - PURPOSE: Patients with diabetes (DM) and chronic kidney disease (CKD) are at increased risk for suboptimal bone health. The study objective was to investigate the relationships between vitamin D (vitD), vitamin K1 (vitK1), and calcium intake with bone mineral density (BMD) and vitamin D status in an ambulatory population with DM and CKD. METHODS: Adults (age 18-80 years; n = 62) with DM and CKD (stages 1-4) were recruited from the Northern Alberta Renal Program. Primary outcome variables included vitD, vitK1, and calcium intake; serum 25(OH)D, 1,25(OH)2D; and BMD as measured by dual X-ray absorptiometry. Statistical significance was determined at P < 0.05. RESULTS: Participants met the estimated average requirement or adequate intake for vitD, vitK1, and calcium intake in 73% (n = 45), 66% (n = 39), and 52% (n = 31), respectively, with a combined intake of micronutrient supplementation and diet. Participants had serum 25(OH)D concentrations ≥75 nmol/L (n = 41), normal BMDs (n = 48), and 66% (n = 41/62) were taking vitD supplements (>1000 IU/D). BMD was positively influenced by serum 25(OH)D. However, serum 25(OH) ≥100 nmol/L was associated with lower BMD (absolute and T-scores) for whole-body and spine (P ≤ 0.05). VitK1 intake (≥200 μg/day) was associated with higher whole-body and femoral-neck BMDs (absoluteand T-scores; P ≤ 0.05). CONCLUSION: VitD status and BMD in adults with DM and CKD was influenced by vitD supplementation and vitK1 intake. SN - 1486-3847 UR - https://www.unboundmedicine.com/medline/citation/27779902/Vitamin_D_Status_and_Bone_Mineral_Density_is_Influenced_by_Vitamin_D_Supplementation_and_Vitamin_K1_Intake_in_Adults_with_Diabetes_and_Chronic_Kidney_Disease_ L2 - https://dcjournal.ca/doi/10.3148/cjdpr-2016-023?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -