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Interpreting the carboxyhaemoglobin concentration in fetal cord blood.
J Dev Physiol. 1989 Feb; 11(2):73-6.JD

Abstract

We calculated the fetal-to-maternal carboxyhaemoglobin concentration ratio in 19 mother-infant pairs at the time of term delivery. Mothers, who had a less than 10% drop in their carboxyhaemoglobin concentration during labour, had an average ratio of 1.40 +/- 0.19. For mothers whose carboxyhaemoglobin concentrations dropped by 10% or more during labour, the average fetal-to-maternal carboxyhaemoglobin concentration ratio was 1.83 +/- 0.48. There was a strong correlation (r = 0.82) between the percent change in maternal carboxyhaemoglobin concentration during labour and the fetal-to-maternal carboxyhaemoglobin concentration ratio at the time of delivery. We conclude that increased CO elimination during labour may be accompanied by rapid changes in the maternal carboxyhaemoglobin concentration, leading to a spuriously high fetal-to-maternal carboxyhemoglobin concentration ratio at the time of delivery.

Authors+Show Affiliations

Leonard MB
Department of Pediatrics, Stanford University School of Medicine, California 94305.
Vreman HJ
No affiliation info available
Ferguson JE
No affiliation info available
Smith DW
No affiliation info available
Stevenson DK
No affiliation info available

MeSH

Carbon MonoxideCarboxyhemoglobinFemaleFetal BloodHumansHyperventilationInfant, NewbornLabor, ObstetricMaternal-Fetal ExchangePregnancySmoking

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2778293

Citation

Leonard, M B., et al. "Interpreting the Carboxyhaemoglobin Concentration in Fetal Cord Blood." Journal of Developmental Physiology, vol. 11, no. 2, 1989, pp. 73-6.
Leonard MB, Vreman HJ, Ferguson JE, et al. Interpreting the carboxyhaemoglobin concentration in fetal cord blood. J Dev Physiol. 1989;11(2):73-6.
Leonard, M. B., Vreman, H. J., Ferguson, J. E., Smith, D. W., & Stevenson, D. K. (1989). Interpreting the carboxyhaemoglobin concentration in fetal cord blood. Journal of Developmental Physiology, 11(2), 73-6.
Leonard MB, et al. Interpreting the Carboxyhaemoglobin Concentration in Fetal Cord Blood. J Dev Physiol. 1989;11(2):73-6. PubMed PMID: 2778293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interpreting the carboxyhaemoglobin concentration in fetal cord blood. AU - Leonard,M B, AU - Vreman,H J, AU - Ferguson,J E,2nd AU - Smith,D W, AU - Stevenson,D K, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 73 EP - 6 JF - Journal of developmental physiology JO - J Dev Physiol VL - 11 IS - 2 N2 - We calculated the fetal-to-maternal carboxyhaemoglobin concentration ratio in 19 mother-infant pairs at the time of term delivery. Mothers, who had a less than 10% drop in their carboxyhaemoglobin concentration during labour, had an average ratio of 1.40 +/- 0.19. For mothers whose carboxyhaemoglobin concentrations dropped by 10% or more during labour, the average fetal-to-maternal carboxyhaemoglobin concentration ratio was 1.83 +/- 0.48. There was a strong correlation (r = 0.82) between the percent change in maternal carboxyhaemoglobin concentration during labour and the fetal-to-maternal carboxyhaemoglobin concentration ratio at the time of delivery. We conclude that increased CO elimination during labour may be accompanied by rapid changes in the maternal carboxyhaemoglobin concentration, leading to a spuriously high fetal-to-maternal carboxyhemoglobin concentration ratio at the time of delivery. SN - 0141-9846 UR - https://www.unboundmedicine.com/medline/citation/2778293/Interpreting_the_carboxyhaemoglobin_concentration_in_fetal_cord_blood_ DB - PRIME DP - Unbound Medicine ER -