Tags

Type your tag names separated by a space and hit enter

Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status with Cognitive Functions in Chinese Adults.
Nutrients. 2016 Oct 24; 8(10)N

Abstract

BACKGROUND/AIM

Studies have indicated a relationship between either gene polymorphism or in vivo B vitamins' nutritional status with cognition in the elderly. However, the combined effects of MTHFR and SLC19A1gene polymorphism with serum folate and vitamin B12 levels on cognition in Chinese adult population remain unclear.

METHODS

Demographic information of 426 Chinese adults aged from 55 to 90 were collected by a well designed self-administered questionnaire. The Montreal Cognitive Assessment test was utilized to evaluate the cognition status of the participants. MTHFR and SLC19A1 genotyping was analyzed using polymerase chain reaction-ligase detection reaction (PCR- LDR) method. Serum folate, vitamin B12 and homocysteine (Hcy) levels were detected by commercial assay kits. Pearson's correlation was used for data analyses and statistical significance was set at p < 0.05.

RESULTS

Serum Hcylevels demonstrated a negative correlation with serum folate (r = -0.301) and vitamin B12 (r = -0.292) levels. The negative correlation found between serum Hcy levels and attention ability was observed in all 426 studied subjects (r = -0.122). Subjects with MTHFR 677 T/T and 1298 A/A genotypes demonstrated a higher serum Hcy levels (p < 0.05). Carriers of MTHFR (1298 A/C + C/C and 1793 G/A) and SLC19A1 80 G/G genotypes showed lower abstraction and delayed memory ability, respectively (p < 0.05). Subjects with MTHFR 1793 G/A genotype along with low serum folate concentration demonstrated the lowest name and orientation abilities. The effects of MTHFR 1793 G/A genotype on cognitive performance were dependent on the status of serum vitamin B12.

CONCLUSION

Cognition of adults was associated with MTHFR, SLC19A1 gene polymorphism and serum Hcy levels. This study clearly establishes a combined effect of MTHFR gene polymorphism and serum B vitamins levels on cognition in Chinese adults.

Authors+Show Affiliations

School of Public Health, Capital Medical University, Beijing 100069, China. ccfdz10223@163.com.School of Public Health, Capital Medical University, Beijing 100069, China. xiaor22@ccmu.edu.cn.Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing 100050, China. NickVH@ccmu.edu.cn.School of Public Health, Capital Medical University, Beijing 100069, China. zhenjie66@ccmu.edu.cn.School of Public Health, Capital Medical University, Beijing 100069, China. huangxiaocheng@126.com.School of Public Health, Capital Medical University, Beijing 100069, China. xuyao1992@ccmu.edu.cn.School of Public Health, Capital Medical University, Beijing 100069, China. sycheng@ccmu.edu.cn.School of Public Health, Capital Medical University, Beijing 100069, China. ylhmedu@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27783031

Citation

Cai, Can, et al. "Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status With Cognitive Functions in Chinese Adults." Nutrients, vol. 8, no. 10, 2016.
Cai C, Xiao R, Van Halm-Lutterodt N, et al. Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status with Cognitive Functions in Chinese Adults. Nutrients. 2016;8(10).
Cai, C., Xiao, R., Van Halm-Lutterodt, N., Zhen, J., Huang, X., Xu, Y., Chen, S., & Yuan, L. (2016). Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status with Cognitive Functions in Chinese Adults. Nutrients, 8(10).
Cai C, et al. Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status With Cognitive Functions in Chinese Adults. Nutrients. 2016 Oct 24;8(10) PubMed PMID: 27783031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status with Cognitive Functions in Chinese Adults. AU - Cai,Can, AU - Xiao,Rong, AU - Van Halm-Lutterodt,Nicholas, AU - Zhen,Jie, AU - Huang,Xiaochen, AU - Xu,Yao, AU - Chen,Shuying, AU - Yuan,Linhong, Y1 - 2016/10/24/ PY - 2016/07/26/received PY - 2016/10/09/revised PY - 2016/10/17/accepted PY - 2016/10/27/pubmed PY - 2017/4/1/medline PY - 2016/10/27/entrez KW - cognition KW - gene polymorphism KW - geriatrics KW - nutrition JF - Nutrients JO - Nutrients VL - 8 IS - 10 N2 - BACKGROUND/AIM: Studies have indicated a relationship between either gene polymorphism or in vivo B vitamins' nutritional status with cognition in the elderly. However, the combined effects of MTHFR and SLC19A1gene polymorphism with serum folate and vitamin B12 levels on cognition in Chinese adult population remain unclear. METHODS: Demographic information of 426 Chinese adults aged from 55 to 90 were collected by a well designed self-administered questionnaire. The Montreal Cognitive Assessment test was utilized to evaluate the cognition status of the participants. MTHFR and SLC19A1 genotyping was analyzed using polymerase chain reaction-ligase detection reaction (PCR- LDR) method. Serum folate, vitamin B12 and homocysteine (Hcy) levels were detected by commercial assay kits. Pearson's correlation was used for data analyses and statistical significance was set at p < 0.05. RESULTS: Serum Hcylevels demonstrated a negative correlation with serum folate (r = -0.301) and vitamin B12 (r = -0.292) levels. The negative correlation found between serum Hcy levels and attention ability was observed in all 426 studied subjects (r = -0.122). Subjects with MTHFR 677 T/T and 1298 A/A genotypes demonstrated a higher serum Hcy levels (p < 0.05). Carriers of MTHFR (1298 A/C + C/C and 1793 G/A) and SLC19A1 80 G/G genotypes showed lower abstraction and delayed memory ability, respectively (p < 0.05). Subjects with MTHFR 1793 G/A genotype along with low serum folate concentration demonstrated the lowest name and orientation abilities. The effects of MTHFR 1793 G/A genotype on cognitive performance were dependent on the status of serum vitamin B12. CONCLUSION: Cognition of adults was associated with MTHFR, SLC19A1 gene polymorphism and serum Hcy levels. This study clearly establishes a combined effect of MTHFR gene polymorphism and serum B vitamins levels on cognition in Chinese adults. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/27783031/Association_of_MTHFR_SLC19A1_Genetic_Polymorphism_Serum_Folate_Vitamin_B12_and_Hcy_Status_with_Cognitive_Functions_in_Chinese_Adults_ L2 - https://www.mdpi.com/resolver?pii=nu8100665 DB - PRIME DP - Unbound Medicine ER -