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Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988).
Int J Lepr Other Mycobact Dis. 1989 Sep; 57(3):622-7.IJ

Abstract

Thirty-three active multibacillary patients from nine counties of Weifang Prefecture, Shandong Province, and 47 active cases from Menla County, Yunnan Province, People's Republic of China, were treated with 24 and 27 months of multidrug therapy (MDT), respectively, in 1983. Clinical assessments, smears, and histopathologic examinations were carried out independently by study teams from the Institutes of Dermatology of these two provinces. Reexaminations at 12-14 months and at termination of therapy showed marked improvement, and there was continued improvement at 12-18 and 33 months on follow up. Conversion of the bacterial index to negativity was 0/33, 5/47 for the patients from Shandong and Yunnan provinces, respectively, at the end of MDT and 2/33 at 12 months' and 17/47 at 18 months' follow up, which increased to 21/33 and 26/44 at 33 months' follow up. Regression of specific infiltration was about 21%-100% after 24-27 months of MDT; further regression to 95%-100% occurred at 33 months' follow up.

Authors+Show Affiliations

Beijing Tropical Medicine Research Institute, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2778368

Citation

Li, H Y., et al. "Short-term Multidrug Therapy in Multibacillary Leprosy--review of 80 Cases in Two Provinces of China (1983-1988)." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 57, no. 3, 1989, pp. 622-7.
Li HY, Yu XL, Zhang MS, et al. Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988). Int J Lepr Other Mycobact Dis. 1989;57(3):622-7.
Li, H. Y., Yu, X. L., Zhang, M. S., Duan, C. X., Huang, W. B., Zhang, S. B., Zhu, K., & Ma, J. F. (1989). Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988). International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 57(3), 622-7.
Li HY, et al. Short-term Multidrug Therapy in Multibacillary Leprosy--review of 80 Cases in Two Provinces of China (1983-1988). Int J Lepr Other Mycobact Dis. 1989;57(3):622-7. PubMed PMID: 2778368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988). AU - Li,H Y, AU - Yu,X L, AU - Zhang,M S, AU - Duan,C X, AU - Huang,W B, AU - Zhang,S B, AU - Zhu,K, AU - Ma,J F, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 622 EP - 7 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 57 IS - 3 N2 - Thirty-three active multibacillary patients from nine counties of Weifang Prefecture, Shandong Province, and 47 active cases from Menla County, Yunnan Province, People's Republic of China, were treated with 24 and 27 months of multidrug therapy (MDT), respectively, in 1983. Clinical assessments, smears, and histopathologic examinations were carried out independently by study teams from the Institutes of Dermatology of these two provinces. Reexaminations at 12-14 months and at termination of therapy showed marked improvement, and there was continued improvement at 12-18 and 33 months on follow up. Conversion of the bacterial index to negativity was 0/33, 5/47 for the patients from Shandong and Yunnan provinces, respectively, at the end of MDT and 2/33 at 12 months' and 17/47 at 18 months' follow up, which increased to 21/33 and 26/44 at 33 months' follow up. Regression of specific infiltration was about 21%-100% after 24-27 months of MDT; further regression to 95%-100% occurred at 33 months' follow up. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2778368/Short_term_multidrug_therapy_in_multibacillary_leprosy__review_of_80_cases_in_two_provinces_of_China__1983_1988__ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -