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Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function.
PLoS One. 2016; 11(10):e0155237.Plos

Abstract

Although the increasing prevalence of thyroid nodular disease (TND) has been partially attributed to the more frequent usage of improved diagnostics, environmental factors, such as exposures to thyroid-disrupting chemicals may contribute to TND and altered thyroid function. We investigated the association between exposures to bisphenol A (BPA), its chlorinated derivatives (ClxBPA), and bisphenol F (BPF) with TND and thyroid measures in adult women. A case-control study in Cyprus and Romania (n = 212) was conducted, where cases were those with thyroid nodules (diameter >3mm), and controls without nodules. Serum TSH and free thyroxine and urinary levels of BPA, BPF and ClxBPA were measured using immunoassays and tandem mass spectrometry, respectively. The association between exposures to BPA compounds and TND, adjusting for age, BMI, thyroid hormones and urinary iodine was assessed using logistic regression. Linear regression was used to explore associations between urinary BPA, BPF and ClxBPA and serum thyroid hormones. With the exception of a chlorinated BPA compound (30%), the rest of bisphenols were quantified in 100% of urine samples. A positive and significant (p<0.05) association was observed between urinary BPA and serum TSH that remained after adjusting for urinary creatinine, age, BMI, study site and disease status; there was no significant association between BPF or ClxBPA with TSH. None of the BPA compounds were associated with higher odds of TND. Our study found associations of urinary BPA with TSH but not with BPF or ClxBPA. A larger study would be justified.

Authors+Show Affiliations

Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.Medical Oncology Department, Prof. Dr. Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania. Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.Endocrinology Department, Archbishop Makarios III Hospital, Nicosia, Cyprus.Radiology Department, Archbishop Makarios III Hospital, Nicosia, Cyprus.Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Nuclear Medicine Department, Prof. Dr. Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania.Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, United States of America.Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27783680

Citation

Andrianou, Xanthi D., et al. "Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol a Derivatives and Thyroid Function." PloS One, vol. 11, no. 10, 2016, pp. e0155237.
Andrianou XD, Gängler S, Piciu A, et al. Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function. PLoS One. 2016;11(10):e0155237.
Andrianou, X. D., Gängler, S., Piciu, A., Charisiadis, P., Zira, C., Aristidou, K., Piciu, D., Hauser, R., & Makris, K. C. (2016). Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function. PloS One, 11(10), e0155237. https://doi.org/10.1371/journal.pone.0155237
Andrianou XD, et al. Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol a Derivatives and Thyroid Function. PLoS One. 2016;11(10):e0155237. PubMed PMID: 27783680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function. AU - Andrianou,Xanthi D, AU - Gängler,Stephanie, AU - Piciu,Andra, AU - Charisiadis,Pantelis, AU - Zira,Christina, AU - Aristidou,Kyriacos, AU - Piciu,Doina, AU - Hauser,Russ, AU - Makris,Konstantinos C, Y1 - 2016/10/26/ PY - 2016/02/15/received PY - 2016/09/14/accepted PY - 2016/10/27/pubmed PY - 2017/6/15/medline PY - 2016/10/27/entrez SP - e0155237 EP - e0155237 JF - PloS one JO - PLoS One VL - 11 IS - 10 N2 - Although the increasing prevalence of thyroid nodular disease (TND) has been partially attributed to the more frequent usage of improved diagnostics, environmental factors, such as exposures to thyroid-disrupting chemicals may contribute to TND and altered thyroid function. We investigated the association between exposures to bisphenol A (BPA), its chlorinated derivatives (ClxBPA), and bisphenol F (BPF) with TND and thyroid measures in adult women. A case-control study in Cyprus and Romania (n = 212) was conducted, where cases were those with thyroid nodules (diameter >3mm), and controls without nodules. Serum TSH and free thyroxine and urinary levels of BPA, BPF and ClxBPA were measured using immunoassays and tandem mass spectrometry, respectively. The association between exposures to BPA compounds and TND, adjusting for age, BMI, thyroid hormones and urinary iodine was assessed using logistic regression. Linear regression was used to explore associations between urinary BPA, BPF and ClxBPA and serum thyroid hormones. With the exception of a chlorinated BPA compound (30%), the rest of bisphenols were quantified in 100% of urine samples. A positive and significant (p<0.05) association was observed between urinary BPA and serum TSH that remained after adjusting for urinary creatinine, age, BMI, study site and disease status; there was no significant association between BPF or ClxBPA with TSH. None of the BPA compounds were associated with higher odds of TND. Our study found associations of urinary BPA with TSH but not with BPF or ClxBPA. A larger study would be justified. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27783680/Human_Exposures_to_Bisphenol_A_Bisphenol_F_and_Chlorinated_Bisphenol_A_Derivatives_and_Thyroid_Function_ DB - PRIME DP - Unbound Medicine ER -