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Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease.
Neurodegener Dis. 2017; 17(2-3):89-96.ND

Abstract

BACKGROUND

Pulse wave velocity is a marker of arterial stiffness and a surrogate marker of vascular damage. Autonomic abnormalities associated with blood pressure are relatively commonly observed in patients with Parkinson's disease (PD).

OBJECTIVE

The purpose of this study was to compare arterial stiffness between patients with PD and controls and investigate the associations between cardiovascular autonomic dysfunction and pulse wave velocity in PD.

METHODS

One hundred twenty-five PD patients without diabetes mellitus were enrolled into this study, along with 22 age-matched controls. Orthostatic vital signs and ambulatory 24-hour blood pressure monitoring values were recorded. Pulse wave velocity was used to evaluate arterial stiffness.

RESULTS

In PD, greater arterial stiffness was associated with orthostatic hypotension, supine hypertension, nocturnal hypertension, and nondipping. Dopaminergic treatment did not influence cardiovascular autonomic dysfunction or arterial stiffness. Although pulse wave velocity was mildly increased in patients with PD compared to controls, the arterial stiffness in PD patients without autonomic failure was similar to that in normal controls. Stiffer arteries were found only in patients with PD and autonomic failure.

CONCLUSION

These findings suggest that cardiovascular autonomic dysfunction is associated with arterial stiffness in PD. PD itself does not affect arterial stiffness, whereas autonomic blood pressure disturbances influence alterations in arterial stiffness and architectural changes in the arteries of PD patients.

Authors+Show Affiliations

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27784025

Citation

Kim, Joong-Seok, et al. "Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients With Parkinson's Disease." Neuro-degenerative Diseases, vol. 17, no. 2-3, 2017, pp. 89-96.
Kim JS, Lee SH, Oh YS, et al. Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease. Neurodegener Dis. 2017;17(2-3):89-96.
Kim, J. S., Lee, S. H., Oh, Y. S., Park, J. W., An, J. Y., Choi, H. S., & Lee, K. S. (2017). Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease. Neuro-degenerative Diseases, 17(2-3), 89-96. https://doi.org/10.1159/000450613
Kim JS, et al. Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients With Parkinson's Disease. Neurodegener Dis. 2017;17(2-3):89-96. PubMed PMID: 27784025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease. AU - Kim,Joong-Seok, AU - Lee,Si-Hoon, AU - Oh,Yoon-Sang, AU - Park,Jeong-Wook, AU - An,Jae-Young, AU - Choi,Hyun-Seok, AU - Lee,Kwang-Soo, Y1 - 2016/10/27/ PY - 2016/03/22/received PY - 2016/09/02/accepted PY - 2016/10/27/pubmed PY - 2017/9/14/medline PY - 2016/10/27/entrez SP - 89 EP - 96 JF - Neuro-degenerative diseases JO - Neurodegener Dis VL - 17 IS - 2-3 N2 - BACKGROUND: Pulse wave velocity is a marker of arterial stiffness and a surrogate marker of vascular damage. Autonomic abnormalities associated with blood pressure are relatively commonly observed in patients with Parkinson's disease (PD). OBJECTIVE: The purpose of this study was to compare arterial stiffness between patients with PD and controls and investigate the associations between cardiovascular autonomic dysfunction and pulse wave velocity in PD. METHODS: One hundred twenty-five PD patients without diabetes mellitus were enrolled into this study, along with 22 age-matched controls. Orthostatic vital signs and ambulatory 24-hour blood pressure monitoring values were recorded. Pulse wave velocity was used to evaluate arterial stiffness. RESULTS: In PD, greater arterial stiffness was associated with orthostatic hypotension, supine hypertension, nocturnal hypertension, and nondipping. Dopaminergic treatment did not influence cardiovascular autonomic dysfunction or arterial stiffness. Although pulse wave velocity was mildly increased in patients with PD compared to controls, the arterial stiffness in PD patients without autonomic failure was similar to that in normal controls. Stiffer arteries were found only in patients with PD and autonomic failure. CONCLUSION: These findings suggest that cardiovascular autonomic dysfunction is associated with arterial stiffness in PD. PD itself does not affect arterial stiffness, whereas autonomic blood pressure disturbances influence alterations in arterial stiffness and architectural changes in the arteries of PD patients. SN - 1660-2862 UR - https://www.unboundmedicine.com/medline/citation/27784025/Arterial_Stiffness_and_Cardiovascular_Autonomic_Dysfunction_in_Patients_with_Parkinson's_Disease_ L2 - https://www.karger.com?DOI=10.1159/000450613 DB - PRIME DP - Unbound Medicine ER -