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Intake of antioxidant vitamins and risk of Parkinson's disease.
Mov Disord. 2016 12; 31(12):1909-1914.MD

Abstract

INTRODUCTION

Oxidative stress is proposed to be one of the potential mechanisms leading to neurodegeneration in Parkinson's disease. However, previous epidemiologic studies investigating associations between antioxidant vitamins, such as vitamins E and C and carotenoids, and PD risk have produced inconsistent results.

OBJECTIVE

The objective of this work was to prospectively examine associations between intakes of antioxidant vitamins, including vitamins E and C and carotenoids, and PD risk.

METHODS

Cases were identified in two large cohorts: the Nurses' Health Study and the Health Professionals Follow-up Study. Cohort members completed semiquantitative food frequency questionnaires every 4 years.

RESULTS

A total of 1036 PD cases were identified. Dietary intakes of vitamin E and carotenoids were not associated with PD risk; the multivariable-adjusted relative risk comparing extreme intake quintiles were 0.93 (95% confidence interval: 0.75-1.14) and 0.97 (95% confidence interval: 0.69-1.37), respectively. Dietary vitamin C intake was significantly associated with reduced PD risk (relative risk: 0.81; 95% confidence interval: 0.65-1.01; ptrend , 0.01); however, this result was not significant in a 4-year lag analysis. For vitamins E and C, intake from foods and supplements combined were also unrelated to PD risk.

CONCLUSIONS

Our results do not support the hypothesis that intake of antioxidant vitamins reduces the risk of PD. © 2016 International Parkinson and Movement Disorder Society.

Links

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Authors+Show Affiliations

Hughes KC
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Gao X
Department of Nutritional Health, The Pennsylvania State University, University Park, Pennsylvania, USA.
Kim IY
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Rimm EB
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Wang M
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Weisskopf MG
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Schwarzschild MA
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ascherio A
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

MeSH

AdultAgedAntioxidantsAscorbic AcidCarotenoidsFemaleFollow-Up StudiesHealth PersonnelHumansMaleMiddle AgedNursesParkinson DiseaseUnited StatesVitamin E

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

27787934

Citation

Hughes, Katherine C., et al. "Intake of Antioxidant Vitamins and Risk of Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 31, no. 12, 2016, pp. 1909-1914.
Hughes KC, Gao X, Kim IY, et al. Intake of antioxidant vitamins and risk of Parkinson's disease. Mov Disord. 2016;31(12):1909-1914.
Hughes, K. C., Gao, X., Kim, I. Y., Rimm, E. B., Wang, M., Weisskopf, M. G., Schwarzschild, M. A., & Ascherio, A. (2016). Intake of antioxidant vitamins and risk of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 31(12), 1909-1914. https://doi.org/10.1002/mds.26819
Hughes KC, et al. Intake of Antioxidant Vitamins and Risk of Parkinson's Disease. Mov Disord. 2016;31(12):1909-1914. PubMed PMID: 27787934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of antioxidant vitamins and risk of Parkinson's disease. AU - Hughes,Katherine C, AU - Gao,Xiang, AU - Kim,Iris Y, AU - Rimm,Eric B, AU - Wang,Molin, AU - Weisskopf,Marc G, AU - Schwarzschild,Michael A, AU - Ascherio,Alberto, Y1 - 2016/10/27/ PY - 2016/04/15/received PY - 2016/08/08/revised PY - 2016/08/11/accepted PY - 2016/10/28/pubmed PY - 2017/12/30/medline PY - 2016/10/28/entrez KW - Parkinson's disease KW - carotenoids KW - oxidative stress KW - vitamin C KW - vitamin E SP - 1909 EP - 1914 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 31 IS - 12 N2 - INTRODUCTION: Oxidative stress is proposed to be one of the potential mechanisms leading to neurodegeneration in Parkinson's disease. However, previous epidemiologic studies investigating associations between antioxidant vitamins, such as vitamins E and C and carotenoids, and PD risk have produced inconsistent results. OBJECTIVE: The objective of this work was to prospectively examine associations between intakes of antioxidant vitamins, including vitamins E and C and carotenoids, and PD risk. METHODS: Cases were identified in two large cohorts: the Nurses' Health Study and the Health Professionals Follow-up Study. Cohort members completed semiquantitative food frequency questionnaires every 4 years. RESULTS: A total of 1036 PD cases were identified. Dietary intakes of vitamin E and carotenoids were not associated with PD risk; the multivariable-adjusted relative risk comparing extreme intake quintiles were 0.93 (95% confidence interval: 0.75-1.14) and 0.97 (95% confidence interval: 0.69-1.37), respectively. Dietary vitamin C intake was significantly associated with reduced PD risk (relative risk: 0.81; 95% confidence interval: 0.65-1.01; ptrend , 0.01); however, this result was not significant in a 4-year lag analysis. For vitamins E and C, intake from foods and supplements combined were also unrelated to PD risk. CONCLUSIONS: Our results do not support the hypothesis that intake of antioxidant vitamins reduces the risk of PD. © 2016 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/27787934/Intake_of_antioxidant_vitamins_and_risk_of_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -