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Intrauterine Adiposity and BMI in 4- to 5-Year-Old Offspring from Diabetic Pregnancies.
Neonatology. 2017; 111(2):177-181.N

Abstract

BACKGROUND

Pregnancies complicated by maternal diabetes are associated with disproportionate intrauterine growth that subsequently may lead to pediatric adiposity.

OBJECTIVES

We investigated whether disproportionate intrauterine growth leads to differences in BMI in 4- to 5-year-old offspring from pregnancies complicated by type 1 (ODM1), type 2 (ODM2), or gestational diabetes (OGDM).

METHODS

Ultrasound data of fetal head-to-abdominal circumference (HC/AC) ratio obtained between 32 and 36 weeks of gestational age were related to offspring anthropometrics that were retrieved from infant welfare centers.

RESULTS

Data from 27 ODM1, 22 ODM2, and 24 OGDM were obtained. Ultrasound measurements for the HC/AC ratio were performed at a mean of 33-34 weeks, with a mean Z-score of the HC/AC ratio of -0.801, -0.879, and 0.017 in ODM1, ODM2, and OGDM. Mean BMI SDS was highest in ODM2 as compared to ODM1 and OGDM. In ODM1 there was a negative correlation between HC/AC ratio and BMI SDS at the ages of 4 and 5 years, but not in ODM2 or OGDM. The birth weight Z-score was positively correlated to BMI SDS in ODM2 and OGDM.

CONCLUSION

Disproportionate intrauterine growth, expressed as the HC/AC ratio, was inversely related with BMI SDS in ODM1 at the ages of 4-5 years, but not in ODM2 or OGDM. Weight and maybe obesity in ODM1 offspring are likely to be related to intrauterine adiposity, whereas overweight in ODM2 and OGDM offspring seems more related to other factors such as birth weight centile, maternal obesity, and altered lifestyle factors during childhood.

Authors+Show Affiliations

Division Woman & Baby, Department of Obstetrics, The University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27788515

Citation

Hammoud, Nurah M., et al. "Intrauterine Adiposity and BMI in 4- to 5-Year-Old Offspring From Diabetic Pregnancies." Neonatology, vol. 111, no. 2, 2017, pp. 177-181.
Hammoud NM, de Valk HW, Biesma DH, et al. Intrauterine Adiposity and BMI in 4- to 5-Year-Old Offspring from Diabetic Pregnancies. Neonatology. 2017;111(2):177-181.
Hammoud, N. M., de Valk, H. W., Biesma, D. H., & Visser, G. H. (2017). Intrauterine Adiposity and BMI in 4- to 5-Year-Old Offspring from Diabetic Pregnancies. Neonatology, 111(2), 177-181. https://doi.org/10.1159/000448681
Hammoud NM, et al. Intrauterine Adiposity and BMI in 4- to 5-Year-Old Offspring From Diabetic Pregnancies. Neonatology. 2017;111(2):177-181. PubMed PMID: 27788515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrauterine Adiposity and BMI in 4- to 5-Year-Old Offspring from Diabetic Pregnancies. AU - Hammoud,Nurah M, AU - de Valk,Harold W, AU - Biesma,Douwe H, AU - Visser,Gerhard H A, Y1 - 2016/10/28/ PY - 2016/05/29/received PY - 2016/07/24/accepted PY - 2016/10/28/pubmed PY - 2017/12/8/medline PY - 2016/10/28/entrez SP - 177 EP - 181 JF - Neonatology JO - Neonatology VL - 111 IS - 2 N2 - BACKGROUND: Pregnancies complicated by maternal diabetes are associated with disproportionate intrauterine growth that subsequently may lead to pediatric adiposity. OBJECTIVES: We investigated whether disproportionate intrauterine growth leads to differences in BMI in 4- to 5-year-old offspring from pregnancies complicated by type 1 (ODM1), type 2 (ODM2), or gestational diabetes (OGDM). METHODS: Ultrasound data of fetal head-to-abdominal circumference (HC/AC) ratio obtained between 32 and 36 weeks of gestational age were related to offspring anthropometrics that were retrieved from infant welfare centers. RESULTS: Data from 27 ODM1, 22 ODM2, and 24 OGDM were obtained. Ultrasound measurements for the HC/AC ratio were performed at a mean of 33-34 weeks, with a mean Z-score of the HC/AC ratio of -0.801, -0.879, and 0.017 in ODM1, ODM2, and OGDM. Mean BMI SDS was highest in ODM2 as compared to ODM1 and OGDM. In ODM1 there was a negative correlation between HC/AC ratio and BMI SDS at the ages of 4 and 5 years, but not in ODM2 or OGDM. The birth weight Z-score was positively correlated to BMI SDS in ODM2 and OGDM. CONCLUSION: Disproportionate intrauterine growth, expressed as the HC/AC ratio, was inversely related with BMI SDS in ODM1 at the ages of 4-5 years, but not in ODM2 or OGDM. Weight and maybe obesity in ODM1 offspring are likely to be related to intrauterine adiposity, whereas overweight in ODM2 and OGDM offspring seems more related to other factors such as birth weight centile, maternal obesity, and altered lifestyle factors during childhood. SN - 1661-7819 UR - https://www.unboundmedicine.com/medline/citation/27788515/Intrauterine_Adiposity_and_BMI_in_4__to_5_Year_Old_Offspring_from_Diabetic_Pregnancies_ L2 - https://www.karger.com?DOI=10.1159/000448681 DB - PRIME DP - Unbound Medicine ER -