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New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities.
J Agric Food Chem. 2016 Nov 23; 64(46):8755-8762.JA

Abstract

Two new benzophenones (1 and 2) and four new xanthones (4-6 and 17) together with 24 known compounds (3, 7-16, and 18-30) were isolated from the roots and twigs of Cratoxylum sumatranum ssp. neriifolium. Their structures were elucidated by spectroscopic methods. Compounds 5 and 26 showed antibacterial activity against Micrococcus luteus, Bacillus cereus, and Staphylococcus epidermis with minimum inhibitory concentrations ranging from 4 to 8 μg/mL, whereas compounds 7, 20, and 26 displayed selective antibacterial activities against Staphylococcus aureus (8 μg/mL), Salmonella typhimurium (4 μg/mL), and Pseudomonas aeruginosa (4 μg/mL), respectively. The radical scavenging effects of some isolated compounds were investigated. Compounds 11 and 21 exhibited potent activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with IC50 values of 7.0 ± 1.0 and 6.0 ± 0.2 μM, respectively.

Authors+Show Affiliations

Tantapakul C
Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
Maneerat W
Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
Sripisut T
School of Cosmetic Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
Ritthiwigrom T
Department of Chemistry, Faculty of Science, Chiang Mai University , Sutep, Muang, Chiang Mai 50200, Thailand.
Andersen RJ
Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia , 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
Cheng P
Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia , 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
Cheenpracha S
School of Science, University of Phayao , Maeka, Muang, Phayao 56000, Thailand.
Raksat A
Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
Laphookhieo S
Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.

MeSH

Anti-Bacterial AgentsBacillus cereusBenzophenonesClusiaceaeMicrobial Sensitivity TestsMolecular StructurePlant ExtractsPseudomonas aeruginosaStaphylococcus aureusXanthones

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27788582

Citation

Tantapakul, Cholpisut, et al. "New Benzophenones and Xanthones From Cratoxylum Sumatranum Ssp. Neriifolium and Their Antibacterial and Antioxidant Activities." Journal of Agricultural and Food Chemistry, vol. 64, no. 46, 2016, pp. 8755-8762.
Tantapakul C, Maneerat W, Sripisut T, et al. New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities. J Agric Food Chem. 2016;64(46):8755-8762.
Tantapakul, C., Maneerat, W., Sripisut, T., Ritthiwigrom, T., Andersen, R. J., Cheng, P., Cheenpracha, S., Raksat, A., & Laphookhieo, S. (2016). New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities. Journal of Agricultural and Food Chemistry, 64(46), 8755-8762.
Tantapakul C, et al. New Benzophenones and Xanthones From Cratoxylum Sumatranum Ssp. Neriifolium and Their Antibacterial and Antioxidant Activities. J Agric Food Chem. 2016 Nov 23;64(46):8755-8762. PubMed PMID: 27788582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities. AU - Tantapakul,Cholpisut, AU - Maneerat,Wisanu, AU - Sripisut,Tawanun, AU - Ritthiwigrom,Thunwadee, AU - Andersen,Raymond J, AU - Cheng,Ping, AU - Cheenpracha,Sarot, AU - Raksat,Achara, AU - Laphookhieo,Surat, Y1 - 2016/11/08/ PY - 2016/10/30/pubmed PY - 2017/6/3/medline PY - 2016/10/30/entrez KW - Cratoxylum sumatranum ssp. neriifolium KW - antibacterial activity KW - antioxidant activity KW - benzophenone KW - xanthone SP - 8755 EP - 8762 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 64 IS - 46 N2 - Two new benzophenones (1 and 2) and four new xanthones (4-6 and 17) together with 24 known compounds (3, 7-16, and 18-30) were isolated from the roots and twigs of Cratoxylum sumatranum ssp. neriifolium. Their structures were elucidated by spectroscopic methods. Compounds 5 and 26 showed antibacterial activity against Micrococcus luteus, Bacillus cereus, and Staphylococcus epidermis with minimum inhibitory concentrations ranging from 4 to 8 μg/mL, whereas compounds 7, 20, and 26 displayed selective antibacterial activities against Staphylococcus aureus (8 μg/mL), Salmonella typhimurium (4 μg/mL), and Pseudomonas aeruginosa (4 μg/mL), respectively. The radical scavenging effects of some isolated compounds were investigated. Compounds 11 and 21 exhibited potent activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with IC50 values of 7.0 ± 1.0 and 6.0 ± 0.2 μM, respectively. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/27788582/New_Benzophenones_and_Xanthones_from_Cratoxylum_sumatranum_ssp__neriifolium_and_Their_Antibacterial_and_Antioxidant_Activities_ DB - PRIME DP - Unbound Medicine ER -