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[Multiple epidermolytic acanthomas of the genitalia].
Ann Dermatol Venereol. 2017 Apr; 144(4):295-300.AD

Abstract

BACKGROUND

Epidermolytic hyperkeratosis presents a particular histological image common to several clinical pictures, including that of keratinopathic ichthyoses. It may also occur fortuitously in various tumoral and inflammatory lesions. It is the elementary histopathological lesion of epidermolytic acanthoma, which may either be single or multiple, and when it occurs in the genital area, is known as epidermolytic hyperkeratosis of the genitalia or multiple epidermolytic acanthoma of the genitalia. Herein, we report two characteristic cases of epidermolytic hyperkeratosis of the genitalia.

PATIENTS AND METHODS

The first patient was a 50-year-old woman consulting for vulvar pain in whom clinical examination revealed the presence of multiple papules on the labia majora and minora. The second patient was a 44-year-old man consulting for verrucous lesions of the scrotum. In both cases, biopsy revealed an histopathological aspect identical with acanthosis, hyperkeratosis, changes in the keratinocytes, in which the cytoplasm contained clear vacuoles, numerous keratohyalin granules and eosinophilic bodies, resulting in a diagnosis of epidermolytic hyperkeratosis of the genitalia.

DISCUSSION

Epidermolytic hyperkeratosis of the genitalia is a rare disease, occurring in middle-aged men and women, but chiefly men. The lesions found on the genital organs may be either single, or, more frequently, multiple, and are described as hyperkeratotic papules, which are also reported under the term multiple epidermolytic acanthomas of the genitalia. The aetiology is unknown; certain authors incriminate a traumatic factor; the role of human papillomavirus (HPV) has been suggested but immunohistochemical studies and molecular biology studies generally reveal no viral DNA. Where lesions cause discomfort to the patient, treatment consists of emollients combined with destruction by cryotherapy or CO2 laser. Imiquimod, calcipotriol, tacrolimus and pimecrolimus have all resulted in regression of lesions.

Authors+Show Affiliations

Cabinet de dermatopathologie Mathurin, 35, avenue Mathurin-Moreau, 75008 Paris, France. Electronic address: imoulonguetmichau@gmail.com.Cabinet de dermatologie, 31, rue de Naples, 75008 Paris, France.Cabinet de dermatologie, 96, avenue de Saint-Ouen, 75018 Paris, France.

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

27789051

Citation

Moulonguet, I, et al. "[Multiple Epidermolytic Acanthomas of the Genitalia]." Annales De Dermatologie Et De Venereologie, vol. 144, no. 4, 2017, pp. 295-300.
Moulonguet I, Serre M, Herskovitch D. [Multiple epidermolytic acanthomas of the genitalia]. Ann Dermatol Venereol. 2017;144(4):295-300.
Moulonguet, I., Serre, M., & Herskovitch, D. (2017). [Multiple epidermolytic acanthomas of the genitalia]. Annales De Dermatologie Et De Venereologie, 144(4), 295-300. https://doi.org/10.1016/j.annder.2016.09.047
Moulonguet I, Serre M, Herskovitch D. [Multiple Epidermolytic Acanthomas of the Genitalia]. Ann Dermatol Venereol. 2017;144(4):295-300. PubMed PMID: 27789051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Multiple epidermolytic acanthomas of the genitalia]. AU - Moulonguet,I, AU - Serre,M, AU - Herskovitch,D, Y1 - 2016/10/24/ PY - 2016/04/02/received PY - 2016/07/08/revised PY - 2016/09/14/accepted PY - 2016/10/30/pubmed PY - 2018/2/21/medline PY - 2016/10/30/entrez KW - Acanthome épidermolytique KW - Acanthomes épidermolytiques génitaux KW - Epidermolytic acanthoma KW - Epidermolytic acanthomas of the genitalia KW - Epidermolytic hyperkeratosis KW - Genitalia KW - Hyperkératose épidermolytique KW - Hyperkératose épidermolytique génitale KW - Organes génitaux SP - 295 EP - 300 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 144 IS - 4 N2 - BACKGROUND: Epidermolytic hyperkeratosis presents a particular histological image common to several clinical pictures, including that of keratinopathic ichthyoses. It may also occur fortuitously in various tumoral and inflammatory lesions. It is the elementary histopathological lesion of epidermolytic acanthoma, which may either be single or multiple, and when it occurs in the genital area, is known as epidermolytic hyperkeratosis of the genitalia or multiple epidermolytic acanthoma of the genitalia. Herein, we report two characteristic cases of epidermolytic hyperkeratosis of the genitalia. PATIENTS AND METHODS: The first patient was a 50-year-old woman consulting for vulvar pain in whom clinical examination revealed the presence of multiple papules on the labia majora and minora. The second patient was a 44-year-old man consulting for verrucous lesions of the scrotum. In both cases, biopsy revealed an histopathological aspect identical with acanthosis, hyperkeratosis, changes in the keratinocytes, in which the cytoplasm contained clear vacuoles, numerous keratohyalin granules and eosinophilic bodies, resulting in a diagnosis of epidermolytic hyperkeratosis of the genitalia. DISCUSSION: Epidermolytic hyperkeratosis of the genitalia is a rare disease, occurring in middle-aged men and women, but chiefly men. The lesions found on the genital organs may be either single, or, more frequently, multiple, and are described as hyperkeratotic papules, which are also reported under the term multiple epidermolytic acanthomas of the genitalia. The aetiology is unknown; certain authors incriminate a traumatic factor; the role of human papillomavirus (HPV) has been suggested but immunohistochemical studies and molecular biology studies generally reveal no viral DNA. Where lesions cause discomfort to the patient, treatment consists of emollients combined with destruction by cryotherapy or CO2 laser. Imiquimod, calcipotriol, tacrolimus and pimecrolimus have all resulted in regression of lesions. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/27789051/[Multiple_epidermolytic_acanthomas_of_the_genitalia]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0151-9638(16)30452-5 DB - PRIME DP - Unbound Medicine ER -