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Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran.
Electron Physician. 2016 Sep; 8(9):3015-3023.EP

Abstract

OBJECTIVE

This study was carried out to investigate the ability of Propolis to ameliorate the adverse cytogenetic effects of Dacarbazine on bone marrow cells.

METHODS

In this experimental in vivo study, 18 mice were used, divided into four groups: control group; Propolis-treated group (treated with 50mg/kg Propolis); and Dacarbazine-treated group (treated with 3.5mg/kg Dacarbazine). The fourth, fifth, and sixth were treated with Dacarbazine and Propolis as pre 2h, post 2h, and concomitant treatment. After five days, the Bone Marrow (BM) samples were obtained for cytogenetic investigation.

RESULTS

The in vivo studies revealed that Dacarbazine induced an abnormalities in polychromatic erythrocytes cells (PECs) as increase of cell with micronuclei, while the dual treatment accompanied with improvement of this abnormalities.

CONCLUSIONS

It could be concluded that there are protective effects of Propolis against the adverse effects of Dacarbazine. It could be recommended to use Propolis as an adjuvant with chemotherapeutic agents.

Authors+Show Affiliations

Faculty of Sciences, Department of Biology "Zoology", Al Faisaliah Campus, King Abdul Aziz University, Kingdom of Saudi Arabia.Faculty of Sciences, Department of Biology "Zoology", Al Faisaliah Campus, King Abdul Aziz University, Kingdom of Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27790359

Citation

Kurdi, Lina Abdul-Fattah, and Fatimah Aliyan Aljeddani. "Reduction of Dacarbazine Cytogenetic Effects On Somatic Cells in Male Mice Using Bee Glue (Propolis) to Manifest the Scientific Miracles in the Quran." Electronic Physician, vol. 8, no. 9, 2016, pp. 3015-3023.
Kurdi LA, Aljeddani FA. Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran. Electron Physician. 2016;8(9):3015-3023.
Kurdi, L. A., & Aljeddani, F. A. (2016). Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran. Electronic Physician, 8(9), 3015-3023.
Kurdi LA, Aljeddani FA. Reduction of Dacarbazine Cytogenetic Effects On Somatic Cells in Male Mice Using Bee Glue (Propolis) to Manifest the Scientific Miracles in the Quran. Electron Physician. 2016;8(9):3015-3023. PubMed PMID: 27790359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran. AU - Kurdi,Lina Abdul-Fattah, AU - Aljeddani,Fatimah Aliyan, Y1 - 2016/09/20/ PY - 2016/05/27/received PY - 2016/07/28/accepted PY - 2016/10/30/pubmed PY - 2016/10/30/medline PY - 2016/10/30/entrez KW - Bone marrow cells KW - Cytogenetic KW - Dacarbazine KW - Mice KW - Propolis SP - 3015 EP - 3023 JF - Electronic physician JO - Electron Physician VL - 8 IS - 9 N2 - OBJECTIVE: This study was carried out to investigate the ability of Propolis to ameliorate the adverse cytogenetic effects of Dacarbazine on bone marrow cells. METHODS: In this experimental in vivo study, 18 mice were used, divided into four groups: control group; Propolis-treated group (treated with 50mg/kg Propolis); and Dacarbazine-treated group (treated with 3.5mg/kg Dacarbazine). The fourth, fifth, and sixth were treated with Dacarbazine and Propolis as pre 2h, post 2h, and concomitant treatment. After five days, the Bone Marrow (BM) samples were obtained for cytogenetic investigation. RESULTS: The in vivo studies revealed that Dacarbazine induced an abnormalities in polychromatic erythrocytes cells (PECs) as increase of cell with micronuclei, while the dual treatment accompanied with improvement of this abnormalities. CONCLUSIONS: It could be concluded that there are protective effects of Propolis against the adverse effects of Dacarbazine. It could be recommended to use Propolis as an adjuvant with chemotherapeutic agents. SN - 2008-5842 UR - https://www.unboundmedicine.com/medline/citation/27790359/Reduction_of_Dacarbazine_cytogenetic_effects_on_somatic_cells_in_male_mice_using_bee_glue_(Propolis)_to_manifest_the_scientific_miracles_in_the_Quran L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27790359/ DB - PRIME DP - Unbound Medicine ER -
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