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Bromelain: from production to commercialisation.
J Sci Food Agric 2017; 97(5):1386-1395JS

Abstract

Bromelain is a mixture of proteolytic enzymes found in pineapple (Ananas comosus) plants. It can be found in several parts of the pineapple plant, including the stem, fruit, leaves and peel. High demand for bromelain has resulted in gradual increases in bromelain production. These increases have led to the need for a bromelain production strategy that yields more purified bromelain at a lower cost and with fewer production steps. Previously, bromelain was purified by conventional centrifugation, ultrafiltration and lyophilisation. Recently, the development of more modern purification techniques such as gel filtration, ion exchange chromatography, affinity chromatography, aqueous two-phase extraction and reverse micelle chromatography has resulted in increased industrial bromelain production worldwide. In addition, recombinant DNA technology has emerged as an alternative strategy for producing large amounts of ultrapure bromelain. An up-to-date compilation of data regarding the commercialisation of bromelain in the clinical, pharmaceutical and industrial fields is provided in this review. © 2016 Society of Chemical Industry.

Authors+Show Affiliations

Faculty of Industrial Science and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia.Faculty of Industrial Science and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia.Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27790704

Citation

Ramli, Aizi Nor Mazila, et al. "Bromelain: From Production to Commercialisation." Journal of the Science of Food and Agriculture, vol. 97, no. 5, 2017, pp. 1386-1395.
Ramli AN, Aznan TN, Illias RM. Bromelain: from production to commercialisation. J Sci Food Agric. 2017;97(5):1386-1395.
Ramli, A. N., Aznan, T. N., & Illias, R. M. (2017). Bromelain: from production to commercialisation. Journal of the Science of Food and Agriculture, 97(5), pp. 1386-1395. doi:10.1002/jsfa.8122.
Ramli AN, Aznan TN, Illias RM. Bromelain: From Production to Commercialisation. J Sci Food Agric. 2017;97(5):1386-1395. PubMed PMID: 27790704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bromelain: from production to commercialisation. AU - Ramli,Aizi Nor Mazila, AU - Aznan,Tuan Norsyalieza Tuan, AU - Illias,Rosli Md, Y1 - 2016/11/29/ PY - 2016/04/19/received PY - 2016/09/26/revised PY - 2016/10/25/accepted PY - 2016/10/30/pubmed PY - 2017/9/7/medline PY - 2016/10/30/entrez KW - bromelain KW - commercialisation KW - pineapple KW - production SP - 1386 EP - 1395 JF - Journal of the science of food and agriculture JO - J. Sci. Food Agric. VL - 97 IS - 5 N2 - Bromelain is a mixture of proteolytic enzymes found in pineapple (Ananas comosus) plants. It can be found in several parts of the pineapple plant, including the stem, fruit, leaves and peel. High demand for bromelain has resulted in gradual increases in bromelain production. These increases have led to the need for a bromelain production strategy that yields more purified bromelain at a lower cost and with fewer production steps. Previously, bromelain was purified by conventional centrifugation, ultrafiltration and lyophilisation. Recently, the development of more modern purification techniques such as gel filtration, ion exchange chromatography, affinity chromatography, aqueous two-phase extraction and reverse micelle chromatography has resulted in increased industrial bromelain production worldwide. In addition, recombinant DNA technology has emerged as an alternative strategy for producing large amounts of ultrapure bromelain. An up-to-date compilation of data regarding the commercialisation of bromelain in the clinical, pharmaceutical and industrial fields is provided in this review. © 2016 Society of Chemical Industry. SN - 1097-0010 UR - https://www.unboundmedicine.com/medline/citation/27790704/Bromelain:_from_production_to_commercialisation_ L2 - https://doi.org/10.1002/jsfa.8122 DB - PRIME DP - Unbound Medicine ER -