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Role of cannabis in digestive disorders.
Eur J Gastroenterol Hepatol. 2017 Feb; 29(2):135-143.EJ

Abstract

Cannabis sativa, a subspecies of the Cannabis plant, contains aromatic hydrocarbon compounds called cannabinoids. [INCREMENT]-Tetrahydrocannabinol is the most abundant cannabinoid and is the main psychotropic constituent. Cannabinoids activate two types of G-protein-coupled cannabinoid receptors: cannabinoid type 1 receptor and cannabinoid type 2 receptor. There has been ongoing interest and development in research to explore the therapeutic potential of cannabis. [INCREMENT]-Tetrahydrocannabinol exerts biological functions on the gastrointestinal (GI) tract. Cannabis has been used for the treatment of GI disorders such as abdominal pain and diarrhea. The endocannabinoid system (i.e. endogenous circulating cannabinoids) performs protective activities in the GI tract and presents a promising therapeutic target against various GI conditions such as inflammatory bowel disease (especially Crohn's disease), irritable bowel syndrome, and secretion and motility-related disorders. The present review sheds light on the role of cannabis in the gut, liver, and pancreas and also on other GI symptoms, such as nausea and vomiting, cannabinoid hyperemesis syndrome, anorexia, weight loss, and chronic abdominal pain. Although the current literature supports the use of marijuana for the treatment of digestive disorders, the clinical efficacy of cannabis and its constituents for various GI disorders remains unclear.

Authors+Show Affiliations

aDepartment of Internal Medicine, Mercer University School of Medicine, Macon bDepartment of Internal Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA cLU-3, Pitampura, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27792038

Citation

Goyal, Hemant, et al. "Role of Cannabis in Digestive Disorders." European Journal of Gastroenterology & Hepatology, vol. 29, no. 2, 2017, pp. 135-143.
Goyal H, Singla U, Gupta U, et al. Role of cannabis in digestive disorders. Eur J Gastroenterol Hepatol. 2017;29(2):135-143.
Goyal, H., Singla, U., Gupta, U., & May, E. (2017). Role of cannabis in digestive disorders. European Journal of Gastroenterology & Hepatology, 29(2), 135-143. https://doi.org/10.1097/MEG.0000000000000779
Goyal H, et al. Role of Cannabis in Digestive Disorders. Eur J Gastroenterol Hepatol. 2017;29(2):135-143. PubMed PMID: 27792038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of cannabis in digestive disorders. AU - Goyal,Hemant, AU - Singla,Umesh, AU - Gupta,Urvashi, AU - May,Elizabeth, PY - 2016/10/30/pubmed PY - 2017/7/21/medline PY - 2016/10/30/entrez SP - 135 EP - 143 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 29 IS - 2 N2 - Cannabis sativa, a subspecies of the Cannabis plant, contains aromatic hydrocarbon compounds called cannabinoids. [INCREMENT]-Tetrahydrocannabinol is the most abundant cannabinoid and is the main psychotropic constituent. Cannabinoids activate two types of G-protein-coupled cannabinoid receptors: cannabinoid type 1 receptor and cannabinoid type 2 receptor. There has been ongoing interest and development in research to explore the therapeutic potential of cannabis. [INCREMENT]-Tetrahydrocannabinol exerts biological functions on the gastrointestinal (GI) tract. Cannabis has been used for the treatment of GI disorders such as abdominal pain and diarrhea. The endocannabinoid system (i.e. endogenous circulating cannabinoids) performs protective activities in the GI tract and presents a promising therapeutic target against various GI conditions such as inflammatory bowel disease (especially Crohn's disease), irritable bowel syndrome, and secretion and motility-related disorders. The present review sheds light on the role of cannabis in the gut, liver, and pancreas and also on other GI symptoms, such as nausea and vomiting, cannabinoid hyperemesis syndrome, anorexia, weight loss, and chronic abdominal pain. Although the current literature supports the use of marijuana for the treatment of digestive disorders, the clinical efficacy of cannabis and its constituents for various GI disorders remains unclear. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/27792038/Role_of_cannabis_in_digestive_disorders_ L2 - http://dx.doi.org/10.1097/MEG.0000000000000779 DB - PRIME DP - Unbound Medicine ER -