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Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life.
J Allergy Clin Immunol. 2017 02; 139(2):541-549.e8.JA

Abstract

BACKGROUND

The evolution of the IgE response to the numerous allergen molecules of Dermatophagoides pteronyssinus is still unknown.

OBJECTIVES

We sought to characterize the evolutionary patterns of the IgE response to 12 molecules of D pteronyssinus from birth to adulthood and to investigate their determinants and clinical relevance.

METHODS

We investigated the clinical data and sera of 722 participants in the German Multicenter Allergy Study, a birth cohort started in 1990. Diagnoses of current allergic rhinitis (AR) related to mite allergy and asthma were based on yearly interviews at the ages of 1 to 13 years and 20 years. IgE to the extract and 12 molecules of D pteronyssinus were tested by means of ImmunoCAP and microarray technology, respectively, in sera collected at ages 1, 2, 3, 5, 6, 7, 10, 13, and 20 years. Exposure to mites at age 6 and 18 months was assessed by measuring Der p 1 weight/weight concentration in house dust.

RESULTS

One hundred ninety-one (26.5%) of 722 participants ever had IgE to D pteronyssinus extract (≥0.35 kUA/L). At age 20 years, their IgE recognized most frequently Der p 2, Der p 1, and Der p 23 (group A molecules; prevalence, >40%), followed by Der p 5, Der p 7, Der p 4, and Der p 21 (group B molecules; prevalence, 15% to 30%) and Der p 11, Der p 18, clone 16, Der p 14, and Der p 15 (group C molecules; prevalence, <10%). IgE sensitization started almost invariably with group A molecules and expanded sequentially first to group B and finally to group C molecules. Early IgE sensitization onset, parental hay fever, and higher exposure to mites were associated with a broader polymolecular IgE sensitization pattern. Participants reaching the broadest IgE sensitization stage (ie, ABC) had significantly higher risk of mite-related AR and asthma than unsensitized participants. IgE to Der p 1 or Der p 23 at age 5 years or less predicted asthma at school age.

CONCLUSIONS

Parental hay fever and early exposure to D pteronyssinus allergens promote IgE polysensitization to several D pteronyssinus molecules, which in turn predicts current mite-related AR and current/future asthma. These results might inspire predictive algorithms and prevention strategies against the progression of IgE sensitization to mites toward AR and asthma.

Authors+Show Affiliations

Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.L'altrastatistica srl, Consultancy & Training, Biostatistics, Rome, Italy.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.Department of Pediatrics Technical University of Munich, Munich, Germany.Department of Pediatrics Technical University of Munich, Munich, Germany.Department of Pediatrics St Hedwig, St Josefs Hospital, Freiburg, Germany.Department of Pediatrics and Adolescent Medicine, University Medicine Mainz, Mainz, Germany.Department of Pediatrics, Heinrich-Heine-University, Düsseldorf, Germany.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for the Development of Allergen Chips, Medical University of Vienna, Vienna, Austria.Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.Department of Paediatric Pneumology & Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: paolo.matricardi@charite.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27793411

Citation

Posa, Daniela, et al. "Evolution and Predictive Value of IgE Responses Toward a Comprehensive Panel of House Dust Mite Allergens During the First 2 Decades of Life." The Journal of Allergy and Clinical Immunology, vol. 139, no. 2, 2017, pp. 541-549.e8.
Posa D, Perna S, Resch Y, et al. Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol. 2017;139(2):541-549.e8.
Posa, D., Perna, S., Resch, Y., Lupinek, C., Panetta, V., Hofmaier, S., Rohrbach, A., Hatzler, L., Grabenhenrich, L., Tsilochristou, O., Chen, K. W., Bauer, C. P., Hoffman, U., Forster, J., Zepp, F., Schuster, A., Wahn, U., Keil, T., Lau, S., ... Matricardi, P. M. (2017). Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. The Journal of Allergy and Clinical Immunology, 139(2), 541-e8. https://doi.org/10.1016/j.jaci.2016.08.014
Posa D, et al. Evolution and Predictive Value of IgE Responses Toward a Comprehensive Panel of House Dust Mite Allergens During the First 2 Decades of Life. J Allergy Clin Immunol. 2017;139(2):541-549.e8. PubMed PMID: 27793411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. AU - Posa,Daniela, AU - Perna,Serena, AU - Resch,Yvonne, AU - Lupinek,Christian, AU - Panetta,Valentina, AU - Hofmaier,Stephanie, AU - Rohrbach,Alexander, AU - Hatzler,Laura, AU - Grabenhenrich,Linus, AU - Tsilochristou,Olympia, AU - Chen,Kuan-Wei, AU - Bauer,Carl-Peter, AU - Hoffman,Ute, AU - Forster,Johannes, AU - Zepp,Fred, AU - Schuster,Antje, AU - Wahn,Ulrich, AU - Keil,Thomas, AU - Lau,Susanne, AU - Vrtala,Susanne, AU - Valenta,Rudolf, AU - Matricardi,Paolo Maria, Y1 - 2016/10/25/ PY - 2016/04/01/received PY - 2016/08/22/revised PY - 2016/08/29/accepted PY - 2016/10/30/pubmed PY - 2017/8/5/medline PY - 2016/10/30/entrez KW - Dermatophagoides pteronyssinus KW - House dust mite allergy KW - IgE KW - allergic rhinitis KW - asthma KW - birth cohort KW - children KW - component-resolved diagnostics KW - microarray KW - prediction KW - recombinant allergens SP - 541 EP - 549.e8 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 139 IS - 2 N2 - BACKGROUND: The evolution of the IgE response to the numerous allergen molecules of Dermatophagoides pteronyssinus is still unknown. OBJECTIVES: We sought to characterize the evolutionary patterns of the IgE response to 12 molecules of D pteronyssinus from birth to adulthood and to investigate their determinants and clinical relevance. METHODS: We investigated the clinical data and sera of 722 participants in the German Multicenter Allergy Study, a birth cohort started in 1990. Diagnoses of current allergic rhinitis (AR) related to mite allergy and asthma were based on yearly interviews at the ages of 1 to 13 years and 20 years. IgE to the extract and 12 molecules of D pteronyssinus were tested by means of ImmunoCAP and microarray technology, respectively, in sera collected at ages 1, 2, 3, 5, 6, 7, 10, 13, and 20 years. Exposure to mites at age 6 and 18 months was assessed by measuring Der p 1 weight/weight concentration in house dust. RESULTS: One hundred ninety-one (26.5%) of 722 participants ever had IgE to D pteronyssinus extract (≥0.35 kUA/L). At age 20 years, their IgE recognized most frequently Der p 2, Der p 1, and Der p 23 (group A molecules; prevalence, >40%), followed by Der p 5, Der p 7, Der p 4, and Der p 21 (group B molecules; prevalence, 15% to 30%) and Der p 11, Der p 18, clone 16, Der p 14, and Der p 15 (group C molecules; prevalence, <10%). IgE sensitization started almost invariably with group A molecules and expanded sequentially first to group B and finally to group C molecules. Early IgE sensitization onset, parental hay fever, and higher exposure to mites were associated with a broader polymolecular IgE sensitization pattern. Participants reaching the broadest IgE sensitization stage (ie, ABC) had significantly higher risk of mite-related AR and asthma than unsensitized participants. IgE to Der p 1 or Der p 23 at age 5 years or less predicted asthma at school age. CONCLUSIONS: Parental hay fever and early exposure to D pteronyssinus allergens promote IgE polysensitization to several D pteronyssinus molecules, which in turn predicts current mite-related AR and current/future asthma. These results might inspire predictive algorithms and prevention strategies against the progression of IgE sensitization to mites toward AR and asthma. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/27793411/Evolution_and_predictive_value_of_IgE_responses_toward_a_comprehensive_panel_of_house_dust_mite_allergens_during_the_first_2_decades_of_life_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(16)30959-9 DB - PRIME DP - Unbound Medicine ER -