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Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis.
J Formos Med Assoc. 2017 Jan; 116(1):4-9.JF

Abstract

BACKGROUND/PURPOSE

Anti-gastric parietal cell antibody (GPCA), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA) have not yet been reported in patients with recurrent aphthous stomatitis (RAS). This study mainly assessed the frequencies of the presence of serum GPCA, TGA, and TMA in different types of RAS patients.

METHODS

Serum GPCA, TGA, and TMA levels were measured in 355 RAS patients of different subtypes and in 355 age- and sex-matched healthy control individuals.

RESULTS

We found that 13.0%, 19.4%, and 19.7% of 355 RAS patients, 16.7%, 23.3%, and 21.7% of 60 major-typed RAS patients, 12.2%, 18.6%, and 19.3% of 295 minor-typed RAS patients, 18.1%, 20.0%, and 21.9% of 160 atrophic glossitis-positive RAS (AG+/RAS) patients, and 8.7%, 19.0%, and 17.9% of 195 AG-negative RAS (AG-/RAS) patients had the presence of GPCA, TGA, and TMA in their sera, respectively. RAS, major-typed RAS, minor-typed RAS, AG+/RAS, and AG-/RAS patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control individuals (all p < 0.001). Of 65 TGA/TMA-positive RAS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 76.9%, 12.3%, and 10.8% of these TGA/TMA-positive RAS patients had normal, lower, and higher serum TSH levels, respectively.

CONCLUSION

We conclude that approximately one-third RAS patients may have GPCA/TGA/TMA positivity in their sera. Because some GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and some TGA/TMA-positive patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these patients should be referred to doctors for further management.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27793414

Citation

Wu, Yang-Che, et al. "Antigastric Parietal Cell and Antithyroid Autoantibodies in Patients With Recurrent Aphthous Stomatitis." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 116, no. 1, 2017, pp. 4-9.
Wu YC, Wu YH, Wang YP, et al. Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. J Formos Med Assoc. 2017;116(1):4-9.
Wu, Y. C., Wu, Y. H., Wang, Y. P., Chang, J. Y., Chen, H. M., & Sun, A. (2017). Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 116(1), 4-9. https://doi.org/10.1016/j.jfma.2016.09.008
Wu YC, et al. Antigastric Parietal Cell and Antithyroid Autoantibodies in Patients With Recurrent Aphthous Stomatitis. J Formos Med Assoc. 2017;116(1):4-9. PubMed PMID: 27793414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. AU - Wu,Yang-Che, AU - Wu,Yu-Hsueh, AU - Wang,Yi-Ping, AU - Chang,Julia Yu-Fong, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2016/10/25/ PY - 2016/09/22/received PY - 2016/09/30/accepted PY - 2016/10/30/pubmed PY - 2017/8/26/medline PY - 2016/10/30/entrez KW - antigastric parietal cell antibody KW - antithyroglobulin antibody KW - antithyroid microsomal antibody KW - atrophic glossitis KW - recurrent aphthous stomatitis SP - 4 EP - 9 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 116 IS - 1 N2 - BACKGROUND/PURPOSE: Anti-gastric parietal cell antibody (GPCA), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA) have not yet been reported in patients with recurrent aphthous stomatitis (RAS). This study mainly assessed the frequencies of the presence of serum GPCA, TGA, and TMA in different types of RAS patients. METHODS: Serum GPCA, TGA, and TMA levels were measured in 355 RAS patients of different subtypes and in 355 age- and sex-matched healthy control individuals. RESULTS: We found that 13.0%, 19.4%, and 19.7% of 355 RAS patients, 16.7%, 23.3%, and 21.7% of 60 major-typed RAS patients, 12.2%, 18.6%, and 19.3% of 295 minor-typed RAS patients, 18.1%, 20.0%, and 21.9% of 160 atrophic glossitis-positive RAS (AG+/RAS) patients, and 8.7%, 19.0%, and 17.9% of 195 AG-negative RAS (AG-/RAS) patients had the presence of GPCA, TGA, and TMA in their sera, respectively. RAS, major-typed RAS, minor-typed RAS, AG+/RAS, and AG-/RAS patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control individuals (all p < 0.001). Of 65 TGA/TMA-positive RAS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 76.9%, 12.3%, and 10.8% of these TGA/TMA-positive RAS patients had normal, lower, and higher serum TSH levels, respectively. CONCLUSION: We conclude that approximately one-third RAS patients may have GPCA/TGA/TMA positivity in their sera. Because some GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and some TGA/TMA-positive patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these patients should be referred to doctors for further management. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/27793414/Antigastric_parietal_cell_and_antithyroid_autoantibodies_in_patients_with_recurrent_aphthous_stomatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(16)30250-9 DB - PRIME DP - Unbound Medicine ER -