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Toxin profiles, PCR ribotypes and resistance patterns of Clostridium difficile: a multicentre study in China, 2012-2013.
Int J Antimicrob Agents. 2016 Dec; 48(6):736-739.IJ

Abstract

A total of 178 clinical isolates of Clostridium difficile were collected from five major teaching hospitals representing northern, eastern and southern China from August 2012 to July 2013. Among the 178 isolates, 162 (91.0%) were toxigenic, including 66 (40.7%) toxin A-negative, toxin B-positive, 95 (58.6%) toxin A-positive, toxin B-positive and only 1 (0.6%) toxin A-, toxin B- and binary toxin-positive. Twenty-nine different PCR ribotypes were identified, of which 017 (21.0%), 012 (17.3%) and novel type H (16.7%) were the most prevalent. PCR ribotypes 027 and 078 were not found. All toxigenic strains were susceptible to metronidazole, vancomycin and piperacillin/tazobactam. Resistance to moxifloxacin, clindamycin, erythromycin, tetracycline, chloramphenicol, fusidic acid, imipenem, linezolid and rifampicin was observed in 45.1%, 79.6%, 75.3%, 46.9%, 3.7%, 29.6%, 4.9%, 2.5% and 12.3% of the isolates, respectively. Ribotype 017 showed resistance to more antimicrobial agents tested than other ribotype strains.

Authors+Show Affiliations

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Shanghai, China.Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Shanghai, China.Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Shanghai, China. Electronic address: huanghaihui@fudan.edu.cn.Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China.Nanfang Hospital, Southern Medical University, Guangzhou, China.Beijing Hospital of Ministry of Health, Beijing, China.Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

27793509

Citation

Gao, Qiong, et al. "Toxin Profiles, PCR Ribotypes and Resistance Patterns of Clostridium Difficile: a Multicentre Study in China, 2012-2013." International Journal of Antimicrobial Agents, vol. 48, no. 6, 2016, pp. 736-739.
Gao Q, Wu S, Huang H, et al. Toxin profiles, PCR ribotypes and resistance patterns of Clostridium difficile: a multicentre study in China, 2012-2013. Int J Antimicrob Agents. 2016;48(6):736-739.
Gao, Q., Wu, S., Huang, H., Ni, Y., Chen, Y., Hu, Y., & Yu, Y. (2016). Toxin profiles, PCR ribotypes and resistance patterns of Clostridium difficile: a multicentre study in China, 2012-2013. International Journal of Antimicrobial Agents, 48(6), 736-739. https://doi.org/10.1016/j.ijantimicag.2016.09.009
Gao Q, et al. Toxin Profiles, PCR Ribotypes and Resistance Patterns of Clostridium Difficile: a Multicentre Study in China, 2012-2013. Int J Antimicrob Agents. 2016;48(6):736-739. PubMed PMID: 27793509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxin profiles, PCR ribotypes and resistance patterns of Clostridium difficile: a multicentre study in China, 2012-2013. AU - Gao,Qiong, AU - Wu,Shi, AU - Huang,Haihui, AU - Ni,Yuxing, AU - Chen,Ye, AU - Hu,Yunjian, AU - Yu,Yunsong, Y1 - 2016/10/17/ PY - 2016/05/04/received PY - 2016/08/21/revised PY - 2016/09/03/accepted PY - 2016/10/30/pubmed PY - 2017/3/14/medline PY - 2016/10/30/entrez KW - Antimicrobial susceptibility KW - Clostridium difficile KW - Multicentre study KW - PCR ribotyping KW - Toxin profile SP - 736 EP - 739 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 48 IS - 6 N2 - A total of 178 clinical isolates of Clostridium difficile were collected from five major teaching hospitals representing northern, eastern and southern China from August 2012 to July 2013. Among the 178 isolates, 162 (91.0%) were toxigenic, including 66 (40.7%) toxin A-negative, toxin B-positive, 95 (58.6%) toxin A-positive, toxin B-positive and only 1 (0.6%) toxin A-, toxin B- and binary toxin-positive. Twenty-nine different PCR ribotypes were identified, of which 017 (21.0%), 012 (17.3%) and novel type H (16.7%) were the most prevalent. PCR ribotypes 027 and 078 were not found. All toxigenic strains were susceptible to metronidazole, vancomycin and piperacillin/tazobactam. Resistance to moxifloxacin, clindamycin, erythromycin, tetracycline, chloramphenicol, fusidic acid, imipenem, linezolid and rifampicin was observed in 45.1%, 79.6%, 75.3%, 46.9%, 3.7%, 29.6%, 4.9%, 2.5% and 12.3% of the isolates, respectively. Ribotype 017 showed resistance to more antimicrobial agents tested than other ribotype strains. SN - 1872-7913 UR - https://www.unboundmedicine.com/medline/citation/27793509/Toxin_profiles_PCR_ribotypes_and_resistance_patterns_of_Clostridium_difficile:_a_multicentre_study_in_China_2012_2013_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(16)30281-3 DB - PRIME DP - Unbound Medicine ER -