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Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014.
Jpn J Infect Dis. 2017 07 24; 70(4):357-361.JJ

Abstract

Acute encephalitis syndrome (AES) is associated with high morbidity and mortality, and affects both children and adults. The main etiologic agent is Japanese encephalitis virus (JEV); however, there are also reports of Dengue virus (DENV) encephalitis. The objectives of this study were to determine the proportion of patients with encephalitis due to JEV during the 2014 outbreak in Son La Province in Vietnam and to explore the association of DENV in non-JEV viral encephalitis cases. Of 90 patients, 6 (6.7%) were positive for anti-JEV immunoglobulin M (IgM), 5 (5.6%) were positive for anti-DENV IgM, 30 (33.3%) were positive for both anti-JEV and anti-DENV IgM, and 56 (62.2%) were positive for flavivirus immunoglobulin G (IgG). In 5 patients with AES, who had positive anti-DENV IgM results in at least one of the paired serum samples, DENV was confirmed by neutralization testing. The incidence of JEV infection was high. There is still a need to maintain and strengthen the national JEV immunization program. This noticeable occurrence of DENV infection was not reported in Son La Province in 2013-2014. Our data suggested that in addition to JEV, DENV was also a causative agent of AES in 2014 in Son La Province, and this finding also confirmed the local occurrence of DENV infection.

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Authors+Show Affiliations

Ngwe Tun MM
Department of Virology, Institute of Tropical Medicine, Nagasaki University.
V Muthugala R
Department of Virology, Institute of Tropical Medicine, Nagasaki University.
Thi Thu Thuy N
Department of Virology, National Institute of Hygiene and Epidemiology.
Hoai Linh Ly P
NIHE-Nagasaki Friendship Laboratory, Nagasaki University.
Thi Hien Thu L
Department of Virology, National Institute of Hygiene and Epidemiology.
Thi Dinh D
Department of Virology, National Institute of Hygiene and Epidemiology.
Viet Hoang N
Department of Virology, National Institute of Hygiene and Epidemiology.
Thi Quynh Mai L
Department of Virology, National Institute of Hygiene and Epidemiology.
Moi ML
Department of Virology, Institute of Tropical Medicine, Nagasaki University.
C Buerano C
Department of Virology, Institute of Tropical Medicine, Nagasaki University.
Morita K
Department of Virology, Institute of Tropical Medicine, Nagasaki University.
Hasebe F
Department of Virology, Institute of Tropical Medicine, Nagasaki University. Center for International Collaborative Research, Nagasaki University.

MeSH

AdolescentAdultAgedAntibodies, ViralChildChild, PreschoolDengueDengue VirusEncephalitis Virus, JapaneseEncephalitis, ViralFemaleHumansImmunoglobulin MIncidenceInfantMaleMiddle AgedNeutralization TestsSerologic TestsVietnamYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27795473

Citation

Ngwe Tun, Mya Myat, et al. "Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014." Japanese Journal of Infectious Diseases, vol. 70, no. 4, 2017, pp. 357-361.
Ngwe Tun MM, V Muthugala R, Thi Thu Thuy N, et al. Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014. Jpn J Infect Dis. 2017;70(4):357-361.
Ngwe Tun, M. M., V Muthugala, R., Thi Thu Thuy, N., Hoai Linh Ly, P., Thi Hien Thu, L., Thi Dinh, D., Viet Hoang, N., Thi Quynh Mai, L., Moi, M. L., C Buerano, C., Morita, K., & Hasebe, F. (2017). Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014. Japanese Journal of Infectious Diseases, 70(4), 357-361. https://doi.org/10.7883/yoken.JJID.2016.246
Ngwe Tun MM, et al. Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014. Jpn J Infect Dis. 2017 07 24;70(4):357-361. PubMed PMID: 27795473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014. AU - Ngwe Tun,Mya Myat, AU - V Muthugala,Rohitha, AU - Thi Thu Thuy,Nguyen, AU - Hoai Linh Ly,Pham, AU - Thi Hien Thu,Le, AU - Thi Dinh,Dang, AU - Viet Hoang,Nguyen, AU - Thi Quynh Mai,Le, AU - Moi,Meng Ling, AU - C Buerano,Corazon, AU - Morita,Kouichi, AU - Hasebe,Futoshi, Y1 - 2016/10/31/ PY - 2016/11/1/pubmed PY - 2018/3/28/medline PY - 2016/11/1/entrez KW - Acute encephalitis KW - Dengue KW - ELISA KW - Japanese encephalitis KW - Neutralization test SP - 357 EP - 361 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 70 IS - 4 N2 - Acute encephalitis syndrome (AES) is associated with high morbidity and mortality, and affects both children and adults. The main etiologic agent is Japanese encephalitis virus (JEV); however, there are also reports of Dengue virus (DENV) encephalitis. The objectives of this study were to determine the proportion of patients with encephalitis due to JEV during the 2014 outbreak in Son La Province in Vietnam and to explore the association of DENV in non-JEV viral encephalitis cases. Of 90 patients, 6 (6.7%) were positive for anti-JEV immunoglobulin M (IgM), 5 (5.6%) were positive for anti-DENV IgM, 30 (33.3%) were positive for both anti-JEV and anti-DENV IgM, and 56 (62.2%) were positive for flavivirus immunoglobulin G (IgG). In 5 patients with AES, who had positive anti-DENV IgM results in at least one of the paired serum samples, DENV was confirmed by neutralization testing. The incidence of JEV infection was high. There is still a need to maintain and strengthen the national JEV immunization program. This noticeable occurrence of DENV infection was not reported in Son La Province in 2013-2014. Our data suggested that in addition to JEV, DENV was also a causative agent of AES in 2014 in Son La Province, and this finding also confirmed the local occurrence of DENV infection. SN - 1884-2836 UR - https://www.unboundmedicine.com/medline/citation/27795473/Dengue_Associated_Acute_Encephalitis_Syndrome_Cases_in_Son_La_Province_Vietnam_in_2014_ L2 - https://dx.doi.org/10.7883/yoken.JJID.2016.246 DB - PRIME DP - Unbound Medicine ER -