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Food allergy: immune mechanisms, diagnosis and immunotherapy.
Nat Rev Immunol 2016; 16(12):751-765NR

Abstract

Food allergy is a pathological, potentially deadly, immune reaction triggered by normally innocuous food protein antigens. The prevalence of food allergies is rising and the standard of care is not optimal, consisting of food-allergen avoidance and treatment of allergen-induced systemic reactions with adrenaline. Thus, accurate diagnosis, prevention and treatment are pressing needs, research into which has been catalysed by technological advances that are enabling a mechanistic understanding of food allergy at the cellular and molecular levels. We discuss the diagnosis and treatment of IgE-mediated food allergy in the context of the immune mechanisms associated with healthy tolerance to common foods, the inflammatory response underlying most food allergies, and immunotherapy-induced desensitization. We highlight promising research advances, therapeutic innovations and the challenges that remain.

Authors+Show Affiliations

Sean N. Parker Center for Allergy and Asthma Research, Stanford University. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University. Division of Allergy, Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California 94305, USA.Sean N. Parker Center for Allergy and Asthma Research, Stanford University. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University.Sean N. Parker Center for Allergy and Asthma Research, Stanford University. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University. Division of Allergy, Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California 94305, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27795547

Citation

Yu, Wong, et al. "Food Allergy: Immune Mechanisms, Diagnosis and Immunotherapy." Nature Reviews. Immunology, vol. 16, no. 12, 2016, pp. 751-765.
Yu W, Freeland DMH, Nadeau KC. Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 2016;16(12):751-765.
Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016). Food allergy: immune mechanisms, diagnosis and immunotherapy. Nature Reviews. Immunology, 16(12), pp. 751-765. doi:10.1038/nri.2016.111.
Yu W, Freeland DMH, Nadeau KC. Food Allergy: Immune Mechanisms, Diagnosis and Immunotherapy. Nat Rev Immunol. 2016;16(12):751-765. PubMed PMID: 27795547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food allergy: immune mechanisms, diagnosis and immunotherapy. AU - Yu,Wong, AU - Freeland,Deborah M Hussey, AU - Nadeau,Kari C, Y1 - 2016/10/31/ PY - 2016/11/1/pubmed PY - 2017/6/16/medline PY - 2016/11/8/entrez SP - 751 EP - 765 JF - Nature reviews. Immunology JO - Nat. Rev. Immunol. VL - 16 IS - 12 N2 - Food allergy is a pathological, potentially deadly, immune reaction triggered by normally innocuous food protein antigens. The prevalence of food allergies is rising and the standard of care is not optimal, consisting of food-allergen avoidance and treatment of allergen-induced systemic reactions with adrenaline. Thus, accurate diagnosis, prevention and treatment are pressing needs, research into which has been catalysed by technological advances that are enabling a mechanistic understanding of food allergy at the cellular and molecular levels. We discuss the diagnosis and treatment of IgE-mediated food allergy in the context of the immune mechanisms associated with healthy tolerance to common foods, the inflammatory response underlying most food allergies, and immunotherapy-induced desensitization. We highlight promising research advances, therapeutic innovations and the challenges that remain. SN - 1474-1741 UR - https://www.unboundmedicine.com/medline/citation/27795547/Food_allergy:_immune_mechanisms_diagnosis_and_immunotherapy_ L2 - http://dx.doi.org/10.1038/nri.2016.111 DB - PRIME DP - Unbound Medicine ER -