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Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial.
Eur J Prev Cardiol 2017; 24(4):399-408EJ

Abstract

Background We assessed the long-term effects of a Mediterranean diet on circulating levels of endothelial progenitor cells (EPCs) and the carotid intima-media thickness (CIMT) in patients with type 2 diabetes. Design This was a parallel, two-arm, single-centre trial. Methods Two hundred and fifteen men and women with newly diagnosed type 2 diabetes were randomized to a Mediterranean diet ( n = 108) or a low-fat diet ( n = 107). The primary outcome measures were changes in the EPC count and the CIMT of the common carotid artery after the treatment period defined as the end of trial (EOT). Results At the EOT, both the CD34+KDR+ and CD34+KDR+CD133+ counts had increased with the Mediterranean diet compared with the low-fat diet ( p < 0.05 for both). At the EOT evaluation, there was a significant ( p = 0.024) difference of -0.025 mm in the CIMT favouring the Mediterranean diet. Compared with the low-fat diet, the rate of regression in the CIMT was higher in the Mediterranean diet group (51 vs. 26%), whereas the rate of progression was lower (25 vs. 50%) ( p = 0.032 for both). Changes in the CIMT were inversely correlated with the changes in EPC levels (CD34+KDR+, r = -0.24, p = 0.020; CD34+KDR+CD133+, r = -0.28, p = 0.014). At the EOT, changes in levels of HbA1c, HOMA, total cholesterol, high-density lipoprotein cholesterol and systolic blood pressure were significantly greater with the Mediterranean diet than with the low-fat diet. Conclusion Compared with a low-fat diet, a long-term trial with Mediterranean diet was associated with an increase in circulating EPCs levels and prevention of the progression of subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes.

Authors+Show Affiliations

1 Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Italy.1 Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Italy.2 Diabetes Unit, Second University of Naples, Italy.2 Diabetes Unit, Second University of Naples, Italy.1 Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Italy.1 Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Italy.1 Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Italy. 2 Diabetes Unit, Second University of Naples, Italy.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27798369

Citation

Maiorino, Maria Ida, et al. "Effect of a Mediterranean Diet On Endothelial Progenitor Cells and Carotid Intima-media Thickness in Type 2 Diabetes: Follow-up of a Randomized Trial." European Journal of Preventive Cardiology, vol. 24, no. 4, 2017, pp. 399-408.
Maiorino MI, Bellastella G, Petrizzo M, et al. Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial. Eur J Prev Cardiol. 2017;24(4):399-408.
Maiorino, M. I., Bellastella, G., Petrizzo, M., Gicchino, M., Caputo, M., Giugliano, D., & Esposito, K. (2017). Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial. European Journal of Preventive Cardiology, 24(4), pp. 399-408. doi:10.1177/2047487316676133.
Maiorino MI, et al. Effect of a Mediterranean Diet On Endothelial Progenitor Cells and Carotid Intima-media Thickness in Type 2 Diabetes: Follow-up of a Randomized Trial. Eur J Prev Cardiol. 2017;24(4):399-408. PubMed PMID: 27798369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial. AU - Maiorino,Maria Ida, AU - Bellastella,Giuseppe, AU - Petrizzo,Michela, AU - Gicchino,Maurizio, AU - Caputo,Mariangela, AU - Giugliano,Dario, AU - Esposito,Katherine, Y1 - 2016/10/27/ PY - 2016/11/1/pubmed PY - 2018/2/22/medline PY - 2016/11/1/entrez KW - Mediterranean diet KW - carotid intima-media thickness KW - endothelial progenitor cells KW - type 2 diabetes SP - 399 EP - 408 JF - European journal of preventive cardiology JO - Eur J Prev Cardiol VL - 24 IS - 4 N2 - Background We assessed the long-term effects of a Mediterranean diet on circulating levels of endothelial progenitor cells (EPCs) and the carotid intima-media thickness (CIMT) in patients with type 2 diabetes. Design This was a parallel, two-arm, single-centre trial. Methods Two hundred and fifteen men and women with newly diagnosed type 2 diabetes were randomized to a Mediterranean diet ( n = 108) or a low-fat diet ( n = 107). The primary outcome measures were changes in the EPC count and the CIMT of the common carotid artery after the treatment period defined as the end of trial (EOT). Results At the EOT, both the CD34+KDR+ and CD34+KDR+CD133+ counts had increased with the Mediterranean diet compared with the low-fat diet ( p < 0.05 for both). At the EOT evaluation, there was a significant ( p = 0.024) difference of -0.025 mm in the CIMT favouring the Mediterranean diet. Compared with the low-fat diet, the rate of regression in the CIMT was higher in the Mediterranean diet group (51 vs. 26%), whereas the rate of progression was lower (25 vs. 50%) ( p = 0.032 for both). Changes in the CIMT were inversely correlated with the changes in EPC levels (CD34+KDR+, r = -0.24, p = 0.020; CD34+KDR+CD133+, r = -0.28, p = 0.014). At the EOT, changes in levels of HbA1c, HOMA, total cholesterol, high-density lipoprotein cholesterol and systolic blood pressure were significantly greater with the Mediterranean diet than with the low-fat diet. Conclusion Compared with a low-fat diet, a long-term trial with Mediterranean diet was associated with an increase in circulating EPCs levels and prevention of the progression of subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. SN - 2047-4881 UR - https://www.unboundmedicine.com/medline/citation/27798369/Effect_of_a_Mediterranean_diet_on_endothelial_progenitor_cells_and_carotid_intima_media_thickness_in_type_2_diabetes:_Follow_up_of_a_randomized_trial_ L2 - http://journals.sagepub.com/doi/full/10.1177/2047487316676133?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -