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[Innate receptors and IL-17 in the immune response against human pathogenic fungi].
Rev Fac Cien Med Univ Nac Cordoba. 2016; 73(3):188-196.RF

Abstract

In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression nduced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system. This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed.

Authors

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Pub Type(s)

Journal Article
Review

Language

spa

PubMed ID

27805556

Citation

Miro, Marìa Soledad, et al. "[Innate Receptors and IL-17 in the Immune Response Against Human Pathogenic Fungi]." Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina), vol. 73, no. 3, 2016, pp. 188-196.
Miro MS, Vigezzi C, Rodriguez E, et al. [Innate receptors and IL-17 in the immune response against human pathogenic fungi]. Rev Fac Cien Med Univ Nac Cordoba. 2016;73(3):188-196.
Miro, M. S., Vigezzi, C., Rodriguez, E., Icely, P. A., Caeiro, J. P., Riera, F., Masih, D. T., & Sotomayor, C. E. (2016). [Innate receptors and IL-17 in the immune response against human pathogenic fungi]. Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina), 73(3), 188-196.
Miro MS, et al. [Innate Receptors and IL-17 in the Immune Response Against Human Pathogenic Fungi]. Rev Fac Cien Med Univ Nac Cordoba. 2016;73(3):188-196. PubMed PMID: 27805556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Innate receptors and IL-17 in the immune response against human pathogenic fungi]. AU - Miro,Marìa Soledad, AU - Vigezzi,Cecilia, AU - Rodriguez,Emilse, AU - Icely,Paula Alejandra, AU - Caeiro,Juan Pablo, AU - Riera,Fernando, AU - Masih,Diana Teresa, AU - Sotomayor,Claudia Elena, PY - 2016/11/3/pubmed PY - 2017/2/2/medline PY - 2016/11/3/entrez SP - 188 EP - 196 JF - Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) JO - Rev Fac Cien Med Univ Nac Cordoba VL - 73 IS - 3 N2 - In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression nduced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system. This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed. SN - 1853-0605 UR - https://www.unboundmedicine.com/medline/citation/27805556/[Innate_receptors_and_IL_17_in_the_immune_response_against_human_pathogenic_fungi]_ L2 - https://medlineplus.gov/molds.html DB - PRIME DP - Unbound Medicine ER -