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Metformin and Vitamin B12 Deficiency: Where Do We Stand?
J Pharm Pharm Sci. 2016 Jul - Sep; 19(3):382-398.JP

Abstract

The association between metformin use and low vitamin B12 levels in type 2 diabetes mellitus patients is well-established. However, many aspects of the topic remain to be elucidated. There is still controversy on the current diagnostic approaches to vitamin B12 deficiency. It is now believed that measuring the serum levels of the vitamin may not reflect its metabolic status. Moreover, there were conflicting results from studies attempting to quantify and explore metformin-associated vitamin B12 deficiency and its clinical impacts. This article reviews the cellular functions of vitamin B12, the biomarkers utilized to define the vitamin deficiency and metformin-induced vitamin B12 deficiency with an emphasis on its prevalence and clinical impacts. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on

ABSTRACT

on the issue's contents page.

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Publisher Full Text

Authors+Show Affiliations

Ahmed MA
Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

MeSH

Diabetes Mellitus, Type 2HumansHypoglycemic AgentsMetforminVitamin B 12 Deficiency

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27806244

Citation

Ahmed, Marwan Awad. "Metformin and Vitamin B12 Deficiency: Where Do We Stand?" Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, vol. 19, no. 3, 2016, pp. 382-398.
Ahmed MA. Metformin and Vitamin B12 Deficiency: Where Do We Stand? J Pharm Pharm Sci. 2016;19(3):382-398.
Ahmed, M. A. (2016). Metformin and Vitamin B12 Deficiency: Where Do We Stand? Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, 19(3), 382-398. https://doi.org/10.18433/J3PK7P
Ahmed MA. Metformin and Vitamin B12 Deficiency: Where Do We Stand. J Pharm Pharm Sci. 2016 Jul - Sep;19(3):382-398. PubMed PMID: 27806244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metformin and Vitamin B12 Deficiency: Where Do We Stand? A1 - Ahmed,Marwan Awad, PY - 2016/11/3/pubmed PY - 2017/11/11/medline PY - 2016/11/3/entrez SP - 382 EP - 398 JF - Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques JO - J Pharm Pharm Sci VL - 19 IS - 3 N2 - The association between metformin use and low vitamin B12 levels in type 2 diabetes mellitus patients is well-established. However, many aspects of the topic remain to be elucidated. There is still controversy on the current diagnostic approaches to vitamin B12 deficiency. It is now believed that measuring the serum levels of the vitamin may not reflect its metabolic status. Moreover, there were conflicting results from studies attempting to quantify and explore metformin-associated vitamin B12 deficiency and its clinical impacts. This article reviews the cellular functions of vitamin B12, the biomarkers utilized to define the vitamin deficiency and metformin-induced vitamin B12 deficiency with an emphasis on its prevalence and clinical impacts. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. SN - 1482-1826 UR - https://www.unboundmedicine.com/medline/citation/27806244/Metformin_and_Vitamin_B12_Deficiency:_Where_Do_We_Stand L2 - https://ejournals.library.ualberta.ca/index.php/JPPS/article/view/27581/20867 DB - PRIME DP - Unbound Medicine ER -