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Maternal high fat diet deficient in vitamin B12 influences long chain polyunsaturated fatty acid composition in rats.
J Matern Fetal Neonatal Med. 2017 Oct; 30(20):2404-2412.JM

Abstract

OBJECTIVE

In India, there is a rise in non-communicable diseases due to diets deficient in vitamin B12, low in docosahexaenoic acid (DHA) and increased consumption of westernized diet. The present study aims to examine the effect of maternal high fat diet (HFD) in absence of vitamin B12 on pregnancy outcome and tissue fatty acid composition in dams.

METHODS

Pregnant Wistar rats were assigned to following diets: Control (C), HFD, High fat diet supplemented with omega-3 fatty acids (HFDO), 4) High fat diet deficient in vitamin B12 (HFBD), High fat deficient in vitamin B12 supplemented with omega-3 fatty acids (HFBDO).

RESULTS

There was no effect on pregnancy outcome as a consequence of different dietary treatments. The levels of DHA in HFBD group were lower (p < 0.05 for both) in placenta as compared to both control and HFD groups, which were improved by omega-3 fatty acid supplementation.

CONCLUSION

This data suggests that maternal HFD (using dairy fat) did not adversely affect pregnancy outcome. However, maternal HFBD reduced levels of placental DHA. This may have implications for reduced fetal brain growth and development.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Jawale S
a Department of Nutritional Medicine , Interactive Research School for Health Affairs, BharatiVidyapeeth Deemed University , Pune , India.
Pulwale A
a Department of Nutritional Medicine , Interactive Research School for Health Affairs, BharatiVidyapeeth Deemed University , Pune , India.
Joshi S
a Department of Nutritional Medicine , Interactive Research School for Health Affairs, BharatiVidyapeeth Deemed University , Pune , India.
Kale A
a Department of Nutritional Medicine , Interactive Research School for Health Affairs, BharatiVidyapeeth Deemed University , Pune , India.

MeSH

AnimalsDiet, High-FatDocosahexaenoic AcidsFemaleLipid MetabolismMalePregnancyPregnancy OutcomePregnancy, AnimalPrenatal Nutritional Physiological PhenomenaRats, WistarVitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27806659

Citation

Jawale, Shruti, et al. "Maternal High Fat Diet Deficient in Vitamin B12 Influences Long Chain Polyunsaturated Fatty Acid Composition in Rats." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 30, no. 20, 2017, pp. 2404-2412.
Jawale S, Pulwale A, Joshi S, et al. Maternal high fat diet deficient in vitamin B12 influences long chain polyunsaturated fatty acid composition in rats. J Matern Fetal Neonatal Med. 2017;30(20):2404-2412.
Jawale, S., Pulwale, A., Joshi, S., & Kale, A. (2017). Maternal high fat diet deficient in vitamin B12 influences long chain polyunsaturated fatty acid composition in rats. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 30(20), 2404-2412. https://doi.org/10.1080/14767058.2016.1251578
Jawale S, et al. Maternal High Fat Diet Deficient in Vitamin B12 Influences Long Chain Polyunsaturated Fatty Acid Composition in Rats. J Matern Fetal Neonatal Med. 2017;30(20):2404-2412. PubMed PMID: 27806659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal high fat diet deficient in vitamin B12 influences long chain polyunsaturated fatty acid composition in rats. AU - Jawale,Shruti, AU - Pulwale,Anubha, AU - Joshi,Sadhana, AU - Kale,Anvita, Y1 - 2016/11/21/ PY - 2016/11/4/pubmed PY - 2018/4/26/medline PY - 2016/11/4/entrez KW - Dairy fat KW - docosahexaenoic acid KW - high fat model KW - placental fatty acids KW - vitamin B12 SP - 2404 EP - 2412 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 30 IS - 20 N2 - OBJECTIVE: In India, there is a rise in non-communicable diseases due to diets deficient in vitamin B12, low in docosahexaenoic acid (DHA) and increased consumption of westernized diet. The present study aims to examine the effect of maternal high fat diet (HFD) in absence of vitamin B12 on pregnancy outcome and tissue fatty acid composition in dams. METHODS: Pregnant Wistar rats were assigned to following diets: Control (C), HFD, High fat diet supplemented with omega-3 fatty acids (HFDO), 4) High fat diet deficient in vitamin B12 (HFBD), High fat deficient in vitamin B12 supplemented with omega-3 fatty acids (HFBDO). RESULTS: There was no effect on pregnancy outcome as a consequence of different dietary treatments. The levels of DHA in HFBD group were lower (p < 0.05 for both) in placenta as compared to both control and HFD groups, which were improved by omega-3 fatty acid supplementation. CONCLUSION: This data suggests that maternal HFD (using dairy fat) did not adversely affect pregnancy outcome. However, maternal HFBD reduced levels of placental DHA. This may have implications for reduced fetal brain growth and development. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/27806659/Maternal_high_fat_diet_deficient_in_vitamin_B12_influences_long_chain_polyunsaturated_fatty_acid_composition_in_rats_ DB - PRIME DP - Unbound Medicine ER -