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β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene on Prostate Carcinogenesis in the TRAMP Model.
Cancer Prev Res (Phila). 2017 Feb; 10(2):161-169.CP

Abstract

The hypothesis that dietary tomato consumption or the intake of the carotenoid lycopene inhibits prostate cancer arose from epidemiologic studies and is supported by preclinical rodent experiments and in vitro mechanistic studies. We hypothesize that variation in activity of carotenoid cleavage enzymes, such as β-carotene 9',10'-oxygenase (BCO2), may alter the impact of dietary tomato and lycopene on prostate carcinogenesis and therefore examined this relationship in the TRAMP model. Starting at 3 weeks of age, TRAMP:Bco2+/+ and TRAMP:Bco2-/- mice were fed either AIN-93G control, or semipurified diets containing 10% tomato powder or 0.25% lycopene beadlets until 18 weeks of age. Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice. Tomato- and lycopene-fed mice had a lower incidence of prostate cancer compared with the control-fed mice. Although Bco2 genotype alone did not significantly change prostate cancer outcome in the control AIN-93G-fed mice, the abilities of lycopene and tomato feeding to inhibit prostate carcinogenesis were significantly attenuated by the loss of Bco2 (Pinteraction = 0.0004 and 0.0383, respectively). Overall, dietary tomato and lycopene inhibited the progression of prostate cancer in TRAMP in a Bco2 genotype-specific manner, potentially implicating the anticancer activity of lycopene cleavage products. This study suggests that genetic variables impacting carotenoid metabolism and accumulation can impact anticancer activity and that future efforts devoted to understanding the interface between tomato carotenoid intake, host genetics, and metabolism will be necessary to clearly elucidate their interactive roles in human prostate carcinogenesis. Cancer Prev Res; 10(2); 161-9. ©2016 AACR.

Authors+Show Affiliations

The Ohio State University Interdisciplinary Program in Nutrition, The Ohio State University, Columbus, Ohio. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio. Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio. Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.Department of Food Science and Technology, The Ohio State University, Columbus, Ohio.Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio.Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio. clinton.8@osu.edu. Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27807077

Citation

Tan, Hsueh-Li, et al. "Β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene On Prostate Carcinogenesis in the TRAMP Model." Cancer Prevention Research (Philadelphia, Pa.), vol. 10, no. 2, 2017, pp. 161-169.
Tan HL, Thomas-Ahner JM, Moran NE, et al. Β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene on Prostate Carcinogenesis in the TRAMP Model. Cancer Prev Res (Phila). 2017;10(2):161-169.
Tan, H. L., Thomas-Ahner, J. M., Moran, N. E., Cooperstone, J. L., Erdman, J. W., Young, G. S., & Clinton, S. K. (2017). Β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene on Prostate Carcinogenesis in the TRAMP Model. Cancer Prevention Research (Philadelphia, Pa.), 10(2), 161-169. https://doi.org/10.1158/1940-6207.CAPR-15-0402
Tan HL, et al. Β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene On Prostate Carcinogenesis in the TRAMP Model. Cancer Prev Res (Phila). 2017;10(2):161-169. PubMed PMID: 27807077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene on Prostate Carcinogenesis in the TRAMP Model. AU - Tan,Hsueh-Li, AU - Thomas-Ahner,Jennifer M, AU - Moran,Nancy E, AU - Cooperstone,Jessica L, AU - Erdman,John W,Jr AU - Young,Gregory S, AU - Clinton,Steven K, Y1 - 2016/11/02/ PY - 2015/12/01/received PY - 2016/10/07/revised PY - 2016/10/23/accepted PY - 2016/11/4/pubmed PY - 2017/11/14/medline PY - 2016/11/4/entrez SP - 161 EP - 169 JF - Cancer prevention research (Philadelphia, Pa.) JO - Cancer Prev Res (Phila) VL - 10 IS - 2 N2 - The hypothesis that dietary tomato consumption or the intake of the carotenoid lycopene inhibits prostate cancer arose from epidemiologic studies and is supported by preclinical rodent experiments and in vitro mechanistic studies. We hypothesize that variation in activity of carotenoid cleavage enzymes, such as β-carotene 9',10'-oxygenase (BCO2), may alter the impact of dietary tomato and lycopene on prostate carcinogenesis and therefore examined this relationship in the TRAMP model. Starting at 3 weeks of age, TRAMP:Bco2+/+ and TRAMP:Bco2-/- mice were fed either AIN-93G control, or semipurified diets containing 10% tomato powder or 0.25% lycopene beadlets until 18 weeks of age. Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice. Tomato- and lycopene-fed mice had a lower incidence of prostate cancer compared with the control-fed mice. Although Bco2 genotype alone did not significantly change prostate cancer outcome in the control AIN-93G-fed mice, the abilities of lycopene and tomato feeding to inhibit prostate carcinogenesis were significantly attenuated by the loss of Bco2 (Pinteraction = 0.0004 and 0.0383, respectively). Overall, dietary tomato and lycopene inhibited the progression of prostate cancer in TRAMP in a Bco2 genotype-specific manner, potentially implicating the anticancer activity of lycopene cleavage products. This study suggests that genetic variables impacting carotenoid metabolism and accumulation can impact anticancer activity and that future efforts devoted to understanding the interface between tomato carotenoid intake, host genetics, and metabolism will be necessary to clearly elucidate their interactive roles in human prostate carcinogenesis. Cancer Prev Res; 10(2); 161-9. ©2016 AACR. SN - 1940-6215 UR - https://www.unboundmedicine.com/medline/citation/27807077/β_Carotene_9'10'_Oxygenase_Modulates_the_Anticancer_Activity_of_Dietary_Tomato_or_Lycopene_on_Prostate_Carcinogenesis_in_the_TRAMP_Model_ L2 - http://cancerpreventionresearch.aacrjournals.org/cgi/pmidlookup?view=long&pmid=27807077 DB - PRIME DP - Unbound Medicine ER -