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Correlation between the viscoelastic properties of the gel layer of swollen HPMC matrix tablets and their in vitro drug release.
Pharm Dev Technol. 2018 Nov; 23(9):838-848.PD

Abstract

Drug release from hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablets is controlled by drug diffusion through the gel layer of the matrix-forming polymer upon hydration, matrix erosion or combination of diffusion and erosion mechanisms. In this study, the relationship between viscoelastic properties of the gel layer of swollen intact matrix tablets and drug release was investigated. Two sets of quetiapine fumarate (QF) matrix tablets were prepared using the high viscosity grade HPMC K4M at low (70 mg/tablet) and high (170 mg/tablet) polymer concentrations. Viscoelastic studies using a controlled stress rheometer were performed on swollen matrices following hydration in the dissolution medium for predetermined time intervals. The gel layer of swollen tablets exhibited predominantly elastic behavior. Results from the in vitro release study showed that drug release was strongly influenced by the viscoelastic properties of the gel layer of K4M tablets, which was further corroborated by results from water uptake studies conducted on intact tablets. The results provide evidence that the viscoelastic properties of the gel layer can be exploited to guide the selection of an appropriate matrix-forming polymer, to better understand the rate of drug release from matrix tablets in vitro and to develop hydrophilic controlled-release formulations.

Authors+Show Affiliations

a Department of Pharmacy, Faculty of Pharmacy , Al-Zaytoonah University of Jordan , Amman , Jordan.a Department of Pharmacy, Faculty of Pharmacy , Al-Zaytoonah University of Jordan , Amman , Jordan.a Department of Pharmacy, Faculty of Pharmacy , Al-Zaytoonah University of Jordan , Amman , Jordan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27808590

Citation

Hamed, Rania, et al. "Correlation Between the Viscoelastic Properties of the Gel Layer of Swollen HPMC Matrix Tablets and Their in Vitro Drug Release." Pharmaceutical Development and Technology, vol. 23, no. 9, 2018, pp. 838-848.
Hamed R, Al Baraghthi T, Sunoqrot S. Correlation between the viscoelastic properties of the gel layer of swollen HPMC matrix tablets and their in vitro drug release. Pharm Dev Technol. 2018;23(9):838-848.
Hamed, R., Al Baraghthi, T., & Sunoqrot, S. (2018). Correlation between the viscoelastic properties of the gel layer of swollen HPMC matrix tablets and their in vitro drug release. Pharmaceutical Development and Technology, 23(9), 838-848. https://doi.org/10.1080/10837450.2016.1257022
Hamed R, Al Baraghthi T, Sunoqrot S. Correlation Between the Viscoelastic Properties of the Gel Layer of Swollen HPMC Matrix Tablets and Their in Vitro Drug Release. Pharm Dev Technol. 2018;23(9):838-848. PubMed PMID: 27808590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between the viscoelastic properties of the gel layer of swollen HPMC matrix tablets and their in vitro drug release. AU - Hamed,Rania, AU - Al Baraghthi,Tamadur, AU - Sunoqrot,Suhair, Y1 - 2016/11/21/ PY - 2016/11/4/pubmed PY - 2018/12/12/medline PY - 2016/11/4/entrez KW - Controlled stress rheometer KW - gel layer KW - in vitro release KW - matrix tablets KW - swollen tablets KW - viscoelasticity SP - 838 EP - 848 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 23 IS - 9 N2 - Drug release from hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablets is controlled by drug diffusion through the gel layer of the matrix-forming polymer upon hydration, matrix erosion or combination of diffusion and erosion mechanisms. In this study, the relationship between viscoelastic properties of the gel layer of swollen intact matrix tablets and drug release was investigated. Two sets of quetiapine fumarate (QF) matrix tablets were prepared using the high viscosity grade HPMC K4M at low (70 mg/tablet) and high (170 mg/tablet) polymer concentrations. Viscoelastic studies using a controlled stress rheometer were performed on swollen matrices following hydration in the dissolution medium for predetermined time intervals. The gel layer of swollen tablets exhibited predominantly elastic behavior. Results from the in vitro release study showed that drug release was strongly influenced by the viscoelastic properties of the gel layer of K4M tablets, which was further corroborated by results from water uptake studies conducted on intact tablets. The results provide evidence that the viscoelastic properties of the gel layer can be exploited to guide the selection of an appropriate matrix-forming polymer, to better understand the rate of drug release from matrix tablets in vitro and to develop hydrophilic controlled-release formulations. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/27808590/Correlation_between_the_viscoelastic_properties_of_the_gel_layer_of_swollen_HPMC_matrix_tablets_and_their_in_vitro_drug_release_ DB - PRIME DP - Unbound Medicine ER -