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Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum.
Nat Prod Res. 2017 Apr; 31(7):810-816.NP

Abstract

Solanerioside A (1), the first example of a diterpenoid glucoside featuring a 14,15-dinor-cyclophytane scaffold, together with three known terpene glucosides (2-4) were isolated from the methanol extract of the leaves of Solanum erianthum (Solanaceae). The structure of 1 was mainly characterised on the basis of extensive spectroscopic analyses, especially from the 2D NMR spectra. In addition, the spectroscopic data of (6E, 10E)-5,12-dihydroxy-β-nerolidol 5-O-β-D-glucopyranoside (3) were reported for the first time. However, these compounds did not display obvious inhibition of LPS-induced NO release in RAW264.7 cells and anti-tumour activity against A549, HepG2, Hela and MCF-7 cells in vitro.

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Authors+Show Affiliations

Peng SY
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Li H
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Yang DP
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China. b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , China.
Bai B
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Zhu LP
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China. b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , China.
Liu Q
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Shen J
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Zhao ZM
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China. b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , China.

MeSH

AnimalsAntineoplastic Agents, PhytogenicCell Line, TumorDiterpenesGlucosidesHumansLipopolysaccharidesMagnetic Resonance SpectroscopyMiceNitric OxidePlant ExtractsPlant LeavesRAW 264.7 CellsSolanumSpectrometry, Mass, Electrospray IonizationSpectrophotometry, Infrared

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27809603

Citation

Peng, Shi-Yi, et al. "Solanerioside A, an Unusual 14,15-dinor-cyclophytane Glucoside From the Leaves of Solanum Erianthum." Natural Product Research, vol. 31, no. 7, 2017, pp. 810-816.
Peng SY, Li H, Yang DP, et al. Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum. Nat Prod Res. 2017;31(7):810-816.
Peng, S. Y., Li, H., Yang, D. P., Bai, B., Zhu, L. P., Liu, Q., Shen, J., & Zhao, Z. M. (2017). Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum. Natural Product Research, 31(7), 810-816. https://doi.org/10.1080/14786419.2016.1247078
Peng SY, et al. Solanerioside A, an Unusual 14,15-dinor-cyclophytane Glucoside From the Leaves of Solanum Erianthum. Nat Prod Res. 2017;31(7):810-816. PubMed PMID: 27809603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum. AU - Peng,Shi-Yi, AU - Li,Hang, AU - Yang,De-Po, AU - Bai,Bai, AU - Zhu,Long-Ping, AU - Liu,Qin, AU - Shen,Juan, AU - Zhao,Zhi-Min, Y1 - 2016/11/04/ PY - 2016/11/5/pubmed PY - 2017/4/6/medline PY - 2016/11/5/entrez KW - Solanaceae KW - Solanum erianthum KW - diterpenoid glucoside KW - sesquiterpene glucoside SP - 810 EP - 816 JF - Natural product research JO - Nat Prod Res VL - 31 IS - 7 N2 - Solanerioside A (1), the first example of a diterpenoid glucoside featuring a 14,15-dinor-cyclophytane scaffold, together with three known terpene glucosides (2-4) were isolated from the methanol extract of the leaves of Solanum erianthum (Solanaceae). The structure of 1 was mainly characterised on the basis of extensive spectroscopic analyses, especially from the 2D NMR spectra. In addition, the spectroscopic data of (6E, 10E)-5,12-dihydroxy-β-nerolidol 5-O-β-D-glucopyranoside (3) were reported for the first time. However, these compounds did not display obvious inhibition of LPS-induced NO release in RAW264.7 cells and anti-tumour activity against A549, HepG2, Hela and MCF-7 cells in vitro. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/27809603/Solanerioside_A_an_unusual_1415_dinor_cyclophytane_glucoside_from_the_leaves_of_Solanum_erianthum_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1247078 DB - PRIME DP - Unbound Medicine ER -