TY - JOUR
T1 - Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders.
A1 - Islam,Md Torequl,
Y1 - 2016/11/03/
PY - 2016/11/5/pubmed
PY - 2017/1/18/medline
PY - 2016/11/5/entrez
KW - AD: Alzheimer’s disease
KW - ALS: Amyotrophic lateral sclerosis
KW - AP-1: activator protein 1
KW - APP: Aβ precursor protein
KW - Aβ: amyloid-β
KW - BBB: blood–brain barrier
KW - BER: base excision repair
KW - BSE: Bovine Spongiform Encephalopathy
KW - CAA: cerebral amyloid angiopathy
KW - CAT: catalase
KW - CBF: cerebral blood flow
KW - CJD: Creutzfeldt-Jakob disease
KW - CNS: central nervous system
KW - COX: cyclooxygenase
KW - CRP: C-reactive protein
KW - Cyt-c: cytochrome c
KW - DA: dopamine
KW - DAG: diacylglycerol
KW - DJ-1: protein deglycase 1
KW - DNMT: DNA methyltransferase
KW - DOPAC: 3, 4-dihydroxyphenylacetic acid
KW - DRG: dorsal root ganglia
KW - DSBs: double strand breaks
KW - EPCs: endothelial progenitor cells
KW - FFI: Fatal Familial Insomnia
KW - FRDA: Friedreich’s ataxia
KW - GPx: glutathione peroxidase
KW - GSH: glutathione
KW - GSS: Gerstmann-Straussler-Scheinker syndrome
KW - HD: Huntington’s disease
KW - HIF-1α: hypoxia-inducible factor-1 alpha
KW - HNE: 4- hydroxynonenal
KW - HVA: homovanillic acid
KW - IL: interleukin
KW - IR: ionizing radiation
KW - JAK: Janus kinase
KW - MAO-B: monoamine oxidase B
KW - MDA: malondialdehyde
KW - MMPs: matrix metalloproteins
KW - NADP: nicotinamide adenine dinucleotide phosphate
KW - NDDs: neurodegenerative diseases
KW - NF-κB: nuclear factor kappa B
KW - NFTs: neurofibrillary tangles
KW - NHEJ: non-homologous end joining
KW - NHR: nucleotide excision repair
KW - Neurodegenerative diseases
KW - PD: Parkinson’s disease
KW - PG: prostaglandin
KW - PGC-1α: peroxisome proliferator-activated receptor-γ co-activator-1α
KW - PPL: phospholipase
KW - PrP: prion protein
KW - RNS: reactive nitrogen species
KW - ROS: reactive oxygen species
KW - SC: spinal cord
KW - SMCs: smooth muscle cells
KW - SOD: superoxide dismutase
KW - SSBs: single strand breaks
KW - TGF-β: tumor growth factor-beta
KW - TNF-α: tumor necrosis factor-alpha
KW - TOMM40: a gene associated with AD
KW - TSEs: Transmissible Spongiform Encephalopathies
KW - VEGF: vascular endothelial growth factor
KW - iNOS: inducible nitric oxide synthase
KW - mitochondrial dysfunction
KW - mtDNA: mitochondrial DNA
KW - mtMP: mitochondrial membrane permeability/potential
KW - oxidative stress
SP - 73
EP - 82
JF - Neurological research
JO - Neurol Res
VL - 39
IS - 1
N2 - Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA. Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA. Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzheimer diseases, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Multiple sclerosis, and Parkinson's diseases. In addition, oxidative stress causing protein misfold may turn to other NDDs include Creutzfeldt-Jakob disease, Bovine Spongiform Encephalopathy, Kuru, Gerstmann-Straussler-Scheinker syndrome, and Fatal Familial Insomnia. An overview of the oxidative stress and mitochondrial dysfunction-linked NDDs has been summarized in this review.
SN - 1743-1328
UR - https://www.unboundmedicine.com/medline/citation/27809706/Oxidative_stress_and_mitochondrial_dysfunction_linked_neurodegenerative_disorders_
DB - PRIME
DP - Unbound Medicine
ER -