TY - JOUR T1 - Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. A1 - Islam,Md Torequl, Y1 - 2016/11/03/ PY - 2016/11/5/pubmed PY - 2017/1/18/medline PY - 2016/11/5/entrez KW - AD: Alzheimer’s disease KW - ALS: Amyotrophic lateral sclerosis KW - AP-1: activator protein 1 KW - APP: Aβ precursor protein KW - Aβ: amyloid-β KW - BBB: blood–brain barrier KW - BER: base excision repair KW - BSE: Bovine Spongiform Encephalopathy KW - CAA: cerebral amyloid angiopathy KW - CAT: catalase KW - CBF: cerebral blood flow KW - CJD: Creutzfeldt-Jakob disease KW - CNS: central nervous system KW - COX: cyclooxygenase KW - CRP: C-reactive protein KW - Cyt-c: cytochrome c KW - DA: dopamine KW - DAG: diacylglycerol KW - DJ-1: protein deglycase 1 KW - DNMT: DNA methyltransferase KW - DOPAC: 3, 4-dihydroxyphenylacetic acid KW - DRG: dorsal root ganglia KW - DSBs: double strand breaks KW - EPCs: endothelial progenitor cells KW - FFI: Fatal Familial Insomnia KW - FRDA: Friedreich’s ataxia KW - GPx: glutathione peroxidase KW - GSH: glutathione KW - GSS: Gerstmann-Straussler-Scheinker syndrome KW - HD: Huntington’s disease KW - HIF-1α: hypoxia-inducible factor-1 alpha KW - HNE: 4- hydroxynonenal KW - HVA: homovanillic acid KW - IL: interleukin KW - IR: ionizing radiation KW - JAK: Janus kinase KW - MAO-B: monoamine oxidase B KW - MDA: malondialdehyde KW - MMPs: matrix metalloproteins KW - NADP: nicotinamide adenine dinucleotide phosphate KW - NDDs: neurodegenerative diseases KW - NF-κB: nuclear factor kappa B KW - NFTs: neurofibrillary tangles KW - NHEJ: non-homologous end joining KW - NHR: nucleotide excision repair KW - Neurodegenerative diseases KW - PD: Parkinson’s disease KW - PG: prostaglandin KW - PGC-1α: peroxisome proliferator-activated receptor-γ co-activator-1α KW - PPL: phospholipase KW - PrP: prion protein KW - RNS: reactive nitrogen species KW - ROS: reactive oxygen species KW - SC: spinal cord KW - SMCs: smooth muscle cells KW - SOD: superoxide dismutase KW - SSBs: single strand breaks KW - TGF-β: tumor growth factor-beta KW - TNF-α: tumor necrosis factor-alpha KW - TOMM40: a gene associated with AD KW - TSEs: Transmissible Spongiform Encephalopathies KW - VEGF: vascular endothelial growth factor KW - iNOS: inducible nitric oxide synthase KW - mitochondrial dysfunction KW - mtDNA: mitochondrial DNA KW - mtMP: mitochondrial membrane permeability/potential KW - oxidative stress SP - 73 EP - 82 JF - Neurological research JO - Neurol Res VL - 39 IS - 1 N2 - Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA. Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA. Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzheimer diseases, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Multiple sclerosis, and Parkinson's diseases. In addition, oxidative stress causing protein misfold may turn to other NDDs include Creutzfeldt-Jakob disease, Bovine Spongiform Encephalopathy, Kuru, Gerstmann-Straussler-Scheinker syndrome, and Fatal Familial Insomnia. An overview of the oxidative stress and mitochondrial dysfunction-linked NDDs has been summarized in this review. SN - 1743-1328 UR - https://www.unboundmedicine.com/medline/citation/27809706/Oxidative_stress_and_mitochondrial_dysfunction_linked_neurodegenerative_disorders_ DB - PRIME DP - Unbound Medicine ER -