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Tea, coffee, and caffeinated beverage consumption and risk of epithelial ovarian cancers.
Cancer Epidemiol 2016; 45:119-125CE

Abstract

BACKGROUND

The risk for epithelial ovarian cancer associated with the consumption of caffeinated beverages (tea, coffee, and soft drinks) and green tea is inconclusive. However, few studies have investigated the type of caffeinated beverage or the type of tea.

OBJECTIVE

We assessed consumption of tea (black/caffeinated tea and green tea separately), coffee, and caffeinated soft drinks, as well as level of consumption, and the risk for epithelial ovarian cancer and its histotypes.

STUDY DESIGN

This study was conducted within a population-based case-control study in Alberta and British Columbia, Canada from 2001 to 2012. After restricting to cases of epithelial invasive cancers and controls aged 40-79 years who completed an interview that included coffee, soft drink, and tea consumption (ascertained starting in 2005 in British Columbia and 2008 in Alberta), there were a total of 524 cases and 1587 controls. Those that did not meet the threshold for beverage consumption (at least once per month for 6 months or more) were classified as non-drinkers. Adult lifetime cumulative consumption (cup-years=cups/day*years) was calculated. Unconditional logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) to describe the association between the relevant drink consumption and risk.

RESULTS

No excess risk was seen for coffee or caffeinated soft drinks. Similarly, any tea consumption was not associated with risk, but when stratified by the type of tea, there was an increase in risk in black tea only drinkers (aOR=1.56; 95% CI:1.07-2.28 for >40 cup-years), but no excess risk for the exclusive green tea drinkers. Similar findings were observed for post-menopausal women. The association for black tea only consumption was mainly seen in the endometrioid histotype (aOR=3.19; 95% CI: 1.32-7.69).

CONCLUSION

Black tea consumption may be associated with an increased risk epithelial ovarian carcinoma. The excess risk is seen only in the endometrioid histotype but not in serous or clear cell. Further studies are required to confirm these findings and identify the constituents in black tea that may increase the risk.

Authors+Show Affiliations

Cancer Control Research, BC Cancer Research Centre, Vancouver, British Columbia, Canada.Department of Internal Medicine, University of New Mexico and UNM Comprehensive Cancer Center, Albuquerque, NM, USA; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Alberta Health Services, Calgary, Alberta, Canada.Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.Department of Pathology, Vancouver General Hospital and British Columba Cancer Agency, Vancouver, British Columbia, Canada.Cancer Control Research, BC Cancer Research Centre, Vancouver, British Columbia, Canada.Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, FL, USA.Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.Cancer Control Research, BC Cancer Research Centre, Vancouver, British Columbia, Canada. Electronic address: nle@bccrc.ca.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27810483

Citation

Leung, Andy C Y., et al. "Tea, Coffee, and Caffeinated Beverage Consumption and Risk of Epithelial Ovarian Cancers." Cancer Epidemiology, vol. 45, 2016, pp. 119-125.
Leung AC, Cook LS, Swenerton K, et al. Tea, coffee, and caffeinated beverage consumption and risk of epithelial ovarian cancers. Cancer Epidemiol. 2016;45:119-125.
Leung, A. C., Cook, L. S., Swenerton, K., Gilks, B., Gallagher, R. P., Magliocco, A., ... Le, N. D. (2016). Tea, coffee, and caffeinated beverage consumption and risk of epithelial ovarian cancers. Cancer Epidemiology, 45, pp. 119-125. doi:10.1016/j.canep.2016.10.010.
Leung AC, et al. Tea, Coffee, and Caffeinated Beverage Consumption and Risk of Epithelial Ovarian Cancers. Cancer Epidemiol. 2016;45:119-125. PubMed PMID: 27810483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tea, coffee, and caffeinated beverage consumption and risk of epithelial ovarian cancers. AU - Leung,Andy C Y, AU - Cook,Linda S, AU - Swenerton,Kenneth, AU - Gilks,Blake, AU - Gallagher,Richard P, AU - Magliocco,Anthony, AU - Steed,Helen, AU - Köbel,Martin, AU - Nation,Jill, AU - Brooks-Wilson,Angela, AU - Le,Nhu D, Y1 - 2016/10/27/ PY - 2016/05/10/received PY - 2016/10/13/revised PY - 2016/10/16/accepted PY - 2016/11/5/pubmed PY - 2017/9/28/medline PY - 2016/11/5/entrez KW - Black tea KW - Caffeine consumption KW - Green tea KW - Ovarian neoplasms KW - Risk factors SP - 119 EP - 125 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 45 N2 - BACKGROUND: The risk for epithelial ovarian cancer associated with the consumption of caffeinated beverages (tea, coffee, and soft drinks) and green tea is inconclusive. However, few studies have investigated the type of caffeinated beverage or the type of tea. OBJECTIVE: We assessed consumption of tea (black/caffeinated tea and green tea separately), coffee, and caffeinated soft drinks, as well as level of consumption, and the risk for epithelial ovarian cancer and its histotypes. STUDY DESIGN: This study was conducted within a population-based case-control study in Alberta and British Columbia, Canada from 2001 to 2012. After restricting to cases of epithelial invasive cancers and controls aged 40-79 years who completed an interview that included coffee, soft drink, and tea consumption (ascertained starting in 2005 in British Columbia and 2008 in Alberta), there were a total of 524 cases and 1587 controls. Those that did not meet the threshold for beverage consumption (at least once per month for 6 months or more) were classified as non-drinkers. Adult lifetime cumulative consumption (cup-years=cups/day*years) was calculated. Unconditional logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) to describe the association between the relevant drink consumption and risk. RESULTS: No excess risk was seen for coffee or caffeinated soft drinks. Similarly, any tea consumption was not associated with risk, but when stratified by the type of tea, there was an increase in risk in black tea only drinkers (aOR=1.56; 95% CI:1.07-2.28 for >40 cup-years), but no excess risk for the exclusive green tea drinkers. Similar findings were observed for post-menopausal women. The association for black tea only consumption was mainly seen in the endometrioid histotype (aOR=3.19; 95% CI: 1.32-7.69). CONCLUSION: Black tea consumption may be associated with an increased risk epithelial ovarian carcinoma. The excess risk is seen only in the endometrioid histotype but not in serous or clear cell. Further studies are required to confirm these findings and identify the constituents in black tea that may increase the risk. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/27810483/Tea_coffee_and_caffeinated_beverage_consumption_and_risk_of_epithelial_ovarian_cancers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(16)30199-0 DB - PRIME DP - Unbound Medicine ER -