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Insecticides induced stress response and recuperation in fish: Biomarkers in blood and tissues related to oxidative damage.
Chemosphere. 2017 Feb; 168:350-357.C

Abstract

The present research investigated the growth, blood, antioxidant response (liver), AChE (brain and muscle) and Na+/K + ATPase in gills of Clarias batrachus exposed to 0 (control), two insecticides, 1.65 mg L-1 chlorpyrifos (CPF) and 2.14 mg L-1 monocrotophos (MCP) for a fixed interval time of 3, 6, 9, 12 and 15 days and follow up depuration process in fresh water for 30 days (at an interval of 7, 15 and 30 days). The toxicants exposed fish indicated significantly (P < 0.05) lower weight gain and HSI. The RBC, Hb, Hct, plasma total protein, glucose, albumin, globulin and respiratory burst activity was reduced. However, WBC, plasma glucose, serum creatinine, and triglycerides were enhanced. The weight gain, HSI and all haematological parameters were reversed following depuration of CPF and MCP exposed fish. Hepatic superoxide dismutase, catalase, lipid peroxidation, reduced glutathione, and glutathione S-transferase activities were significantly activated whereas glutathione peroxidase was inhibited in both tested groups. All the antioxidant enzymes were reversed on day 15 in MCP concentration, whereas CPF on day 30 of depuration process. The inhibition of acetylcholinesterase (brain, muscle) and gill Na+/K + ATPase activities were more in CPF exposure and early recovery in MCP. The results indicated that depuration process might help in detoxification of fish and improve growth, haematological conditions, oxidative stress and AChE, Na+/K + ATPase activity. However, further studies are needed in different fish species with different toxicants to support this strategy of depuration process in order to detoxify polluted fish.

Authors+Show Affiliations

Department of Zoology, College of Science, Osmania University, Hyderabad, 500 007, India.Department of Zoology, College of Science, Osmania University, Hyderabad, 500 007, India.Department of Zoology, College of Science, Osmania University, Hyderabad, 500 007, India.Toxicology Unit, Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.Toxicology Unit, Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. Electronic address: ghousia@iict.res.in.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27810534

Citation

Narra, Madhusudan Reddy, et al. "Insecticides Induced Stress Response and Recuperation in Fish: Biomarkers in Blood and Tissues Related to Oxidative Damage." Chemosphere, vol. 168, 2017, pp. 350-357.
Narra MR, Rajender K, Reddy RR, et al. Insecticides induced stress response and recuperation in fish: Biomarkers in blood and tissues related to oxidative damage. Chemosphere. 2017;168:350-357.
Narra, M. R., Rajender, K., Reddy, R. R., Murty, U. S., & Begum, G. (2017). Insecticides induced stress response and recuperation in fish: Biomarkers in blood and tissues related to oxidative damage. Chemosphere, 168, 350-357. https://doi.org/10.1016/j.chemosphere.2016.10.066
Narra MR, et al. Insecticides Induced Stress Response and Recuperation in Fish: Biomarkers in Blood and Tissues Related to Oxidative Damage. Chemosphere. 2017;168:350-357. PubMed PMID: 27810534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insecticides induced stress response and recuperation in fish: Biomarkers in blood and tissues related to oxidative damage. AU - Narra,Madhusudan Reddy, AU - Rajender,Kodimyala, AU - Reddy,R Rudra, AU - Murty,U Suryanarayana, AU - Begum,Ghousia, Y1 - 2016/10/27/ PY - 2016/08/10/received PY - 2016/10/18/revised PY - 2016/10/18/accepted PY - 2016/11/5/pubmed PY - 2017/4/4/medline PY - 2016/11/5/entrez KW - Food fish KW - Insecticides KW - Recuperation KW - Stress response SP - 350 EP - 357 JF - Chemosphere JO - Chemosphere VL - 168 N2 - The present research investigated the growth, blood, antioxidant response (liver), AChE (brain and muscle) and Na+/K + ATPase in gills of Clarias batrachus exposed to 0 (control), two insecticides, 1.65 mg L-1 chlorpyrifos (CPF) and 2.14 mg L-1 monocrotophos (MCP) for a fixed interval time of 3, 6, 9, 12 and 15 days and follow up depuration process in fresh water for 30 days (at an interval of 7, 15 and 30 days). The toxicants exposed fish indicated significantly (P < 0.05) lower weight gain and HSI. The RBC, Hb, Hct, plasma total protein, glucose, albumin, globulin and respiratory burst activity was reduced. However, WBC, plasma glucose, serum creatinine, and triglycerides were enhanced. The weight gain, HSI and all haematological parameters were reversed following depuration of CPF and MCP exposed fish. Hepatic superoxide dismutase, catalase, lipid peroxidation, reduced glutathione, and glutathione S-transferase activities were significantly activated whereas glutathione peroxidase was inhibited in both tested groups. All the antioxidant enzymes were reversed on day 15 in MCP concentration, whereas CPF on day 30 of depuration process. The inhibition of acetylcholinesterase (brain, muscle) and gill Na+/K + ATPase activities were more in CPF exposure and early recovery in MCP. The results indicated that depuration process might help in detoxification of fish and improve growth, haematological conditions, oxidative stress and AChE, Na+/K + ATPase activity. However, further studies are needed in different fish species with different toxicants to support this strategy of depuration process in order to detoxify polluted fish. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/27810534/Insecticides_induced_stress_response_and_recuperation_in_fish:_Biomarkers_in_blood_and_tissues_related_to_oxidative_damage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(16)31450-3 DB - PRIME DP - Unbound Medicine ER -