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A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes.
PLoS One. 2016; 11(11):e0165978.Plos

Abstract

Middle East Respiratory syndrome (MERS) first emerged in Saudi Arabia in 2012 and remains a global health concern. The objective of this study was to compare the clinical features and risk factors for adverse outcome in patients with RT-PCR confirmed MERS and in those with acute respiratory disease who were MERS-CoV negative, presenting to the King Fahad Medical City (KFMC) in Riyadh between October 2012 and May 2014. The demographics, clinical and laboratory characteristics and clinical outcomes of patients with RT-PCR confirmed MERS-CoV infection was compared with those testing negative MERS-CoV PCR. Health care workers (HCW) with MERS were compared with MERS patients who were not health care workers. One hundred and fifty nine patients were eligible for inclusion. Forty eight tested positive for MERS CoV, 44 (92%) being hospital acquired infections and 23 were HCW. There were 111 MERS-CoV negative patients with acute respiratory illnesses included in this study as "negative controls". Patient with confirmed MERS-CoV infection were not clinically distinguishable from those with negative MERS-CoV RT-PCR results although diarrhoea was commoner in MERS patients. A high level of suspicion in initiating laboratory tests for MERS-CoV is therefore indicated. Variables associated with adverse outcome were older age and diabetes as a co-morbid illness. Interestingly, co-morbid illnesses other than diabetes were not significantly associated with poor outcome. Health care workers with MERS had a markedly better clinical outcome compared to non HCW MERS patients.

Authors+Show Affiliations

King Fahad Medical City, Riyadh, Saudi Arabia.King Fahad Medical City, Riyadh, Saudi Arabia.School of Public Health, The University of Hong Kong, Hong Kong SAR.King Fahad Medical City, Riyadh, Saudi Arabia.King Fahad Medical City, Riyadh, Saudi Arabia.King Fahad Medical City, Riyadh, Saudi Arabia.School of Public Health, The University of Hong Kong, Hong Kong SAR.School of Public Health, The University of Hong Kong, Hong Kong SAR.King Fahad Medical City, Riyadh, Saudi Arabia.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27812197

Citation

Garbati, Musa A., et al. "A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised With Acute Respiratory Disease Due to MERS Coronavirus or Other Causes." PloS One, vol. 11, no. 11, 2016, pp. e0165978.
Garbati MA, Fagbo SF, Fang VJ, et al. A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes. PLoS One. 2016;11(11):e0165978.
Garbati, M. A., Fagbo, S. F., Fang, V. J., Skakni, L., Joseph, M., Wani, T. A., Cowling, B. J., Peiris, M., & Hakawi, A. (2016). A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes. PloS One, 11(11), e0165978. https://doi.org/10.1371/journal.pone.0165978
Garbati MA, et al. A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised With Acute Respiratory Disease Due to MERS Coronavirus or Other Causes. PLoS One. 2016;11(11):e0165978. PubMed PMID: 27812197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes. AU - Garbati,Musa A, AU - Fagbo,Shamsudeen F, AU - Fang,Vicky J, AU - Skakni,Leila, AU - Joseph,Mercy, AU - Wani,Tariq A, AU - Cowling,Benjamin J, AU - Peiris,Malik, AU - Hakawi,Ahmed, Y1 - 2016/11/03/ PY - 2016/08/12/received PY - 2016/10/20/accepted PY - 2016/11/5/pubmed PY - 2017/6/29/medline PY - 2016/11/5/entrez SP - e0165978 EP - e0165978 JF - PloS one JO - PLoS One VL - 11 IS - 11 N2 - Middle East Respiratory syndrome (MERS) first emerged in Saudi Arabia in 2012 and remains a global health concern. The objective of this study was to compare the clinical features and risk factors for adverse outcome in patients with RT-PCR confirmed MERS and in those with acute respiratory disease who were MERS-CoV negative, presenting to the King Fahad Medical City (KFMC) in Riyadh between October 2012 and May 2014. The demographics, clinical and laboratory characteristics and clinical outcomes of patients with RT-PCR confirmed MERS-CoV infection was compared with those testing negative MERS-CoV PCR. Health care workers (HCW) with MERS were compared with MERS patients who were not health care workers. One hundred and fifty nine patients were eligible for inclusion. Forty eight tested positive for MERS CoV, 44 (92%) being hospital acquired infections and 23 were HCW. There were 111 MERS-CoV negative patients with acute respiratory illnesses included in this study as "negative controls". Patient with confirmed MERS-CoV infection were not clinically distinguishable from those with negative MERS-CoV RT-PCR results although diarrhoea was commoner in MERS patients. A high level of suspicion in initiating laboratory tests for MERS-CoV is therefore indicated. Variables associated with adverse outcome were older age and diabetes as a co-morbid illness. Interestingly, co-morbid illnesses other than diabetes were not significantly associated with poor outcome. Health care workers with MERS had a markedly better clinical outcome compared to non HCW MERS patients. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27812197/A_Comparative_Study_of_Clinical_Presentation_and_Risk_Factors_for_Adverse_Outcome_in_Patients_Hospitalised_with_Acute_Respiratory_Disease_Due_to_MERS_Coronavirus_or_Other_Causes_ L2 - https://dx.plos.org/10.1371/journal.pone.0165978 DB - PRIME DP - Unbound Medicine ER -