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AMPK in Neurodegenerative Diseases.
Exp Suppl. 2016; 107:153-177.ES

Abstract

Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are neurodegenerative disorders that are characterized by a progressive degeneration of nerve cells eventually leading to dementia. While these diseases affect different neuronal populations and present distinct clinical features, they share in common several features and signaling pathways. In particular, energy metabolism defects, oxidative stress, and excitotoxicity are commonly described and might be correlated with AMP-activated protein kinase (AMPK) deregulation. AMPK is a master energy sensor which was reported to be overactivated in the brain of patients affected by these neurodegenerative disorders. While the exact role played by AMPK in these diseases remains to be clearly established, several studies reported the implication of AMPK in various signaling pathways that are involved in these diseases' progression. In this chapter, we review the current literature regarding the involvement of AMPK in the development of these diseases and discuss the common pathways involved.

Authors+Show Affiliations

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT, F-59000, Lille, France.Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT, F-59000, Lille, France. valerie.vingtdeux@inserm.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

27812980

Citation

Domise, Manon, and Valérie Vingtdeux. "AMPK in Neurodegenerative Diseases." Experientia Supplementum (2012), vol. 107, 2016, pp. 153-177.
Domise M, Vingtdeux V. AMPK in Neurodegenerative Diseases. Exp Suppl. 2016;107:153-177.
Domise, M., & Vingtdeux, V. (2016). AMPK in Neurodegenerative Diseases. Experientia Supplementum (2012), 107, 153-177.
Domise M, Vingtdeux V. AMPK in Neurodegenerative Diseases. Exp Suppl. 2016;107:153-177. PubMed PMID: 27812980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - AMPK in Neurodegenerative Diseases. AU - Domise,Manon, AU - Vingtdeux,Valérie, PY - 2016/11/5/pubmed PY - 2017/6/3/medline PY - 2016/11/5/entrez KW - AMPK KW - Alzheimer’s disease KW - Amyotrophic lateral sclerosis KW - Huntington’s disease KW - Neurodegeneration KW - Parkinson’s disease SP - 153 EP - 177 JF - Experientia supplementum (2012) JO - Exp Suppl VL - 107 N2 - Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are neurodegenerative disorders that are characterized by a progressive degeneration of nerve cells eventually leading to dementia. While these diseases affect different neuronal populations and present distinct clinical features, they share in common several features and signaling pathways. In particular, energy metabolism defects, oxidative stress, and excitotoxicity are commonly described and might be correlated with AMP-activated protein kinase (AMPK) deregulation. AMPK is a master energy sensor which was reported to be overactivated in the brain of patients affected by these neurodegenerative disorders. While the exact role played by AMPK in these diseases remains to be clearly established, several studies reported the implication of AMPK in various signaling pathways that are involved in these diseases' progression. In this chapter, we review the current literature regarding the involvement of AMPK in the development of these diseases and discuss the common pathways involved. SN - 1664-431X UR - https://www.unboundmedicine.com/medline/citation/27812980/AMPK_in_Neurodegenerative_Diseases_ L2 - https://medlineplus.gov/dementia.html DB - PRIME DP - Unbound Medicine ER -