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Multiplex immunoassays in endometriosis: An array of possibilities.
Front Biosci (Landmark Ed). 2017 01 01; 22:479-492.FB

Abstract

Multiplex immunoassays range from small-scaled multiplex sandwich ELISAs in a planar or bead-based format to the more expanded antibody arrays employing direct sample labeling. The plethora of data generated from these arrays could be of great interest to understand a complex disorder such as endometriosis. Multiplex immunoassay analysis may provide information on disease pathology and may lead to improved, timely diagnosis. Until now, the use of multiplex immunoassays has been limited in endometriosis. With the constant development of multiplex technologies, future studies should focus on implementing these techniques, and combining them with multivariate statistical analysis. In this review, we provide an overview of multiplex immunoassay methods used in endometriosis studies and the data sets acquired by these methodologies. These data and future studies might provide novel insights for biomarker discovery and investigation of the pathogenesis in endometriosis.

Authors+Show Affiliations

KU Leuven, Department of Development and Regeneration, Organ systems, Leuven, Belgium and Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium.Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Kasteelpark Arenberg 10, Box 2446, 3001 Leuven, Belgium.KU Leuven, Department of Cellular and Molecular Medicine, Campus Gasthuisberg, Leuven, Belgium and SyBioMa, Interfaculty Centre for Systems Biology based Mass Spectrometry, Campus Gasthuisberg, Leuven, Belgium.Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Kasteelpark Arenberg 10, Box 2446, 3001 Leuven, Belgium.KU Leuven, Department of Development and Regeneration, Organ systems, Leuven, Belgium and Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium.KU Leuven, Department of Development and Regeneration, Organ Systems, Leuven, Belgium, 2Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium, amelie.fassbender@yahoo.com.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27814626

Citation

O, Dorien F., et al. "Multiplex Immunoassays in Endometriosis: an Array of Possibilities." Frontiers in Bioscience (Landmark Edition), vol. 22, 2017, pp. 479-492.
O DF, El Aalamat Y, Waelkens E, et al. Multiplex immunoassays in endometriosis: An array of possibilities. Front Biosci (Landmark Ed). 2017;22:479-492.
O, D. F., El Aalamat, Y., Waelkens, E., De Moor, B., D'Hooghe, T., & Fassbender, A. (2017). Multiplex immunoassays in endometriosis: An array of possibilities. Frontiers in Bioscience (Landmark Edition), 22, 479-492.
O DF, et al. Multiplex Immunoassays in Endometriosis: an Array of Possibilities. Front Biosci (Landmark Ed). 2017 01 1;22:479-492. PubMed PMID: 27814626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiplex immunoassays in endometriosis: An array of possibilities. AU - O,Dorien F, AU - El Aalamat,Yousef, AU - Waelkens,Etienne, AU - De Moor,Bart, AU - D'Hooghe,Thomas, AU - Fassbender,Amelie, Y1 - 2017/01/01/ PY - 2016/11/5/entrez PY - 2016/11/5/pubmed PY - 2018/1/6/medline SP - 479 EP - 492 JF - Frontiers in bioscience (Landmark edition) JO - Front Biosci (Landmark Ed) VL - 22 N2 - Multiplex immunoassays range from small-scaled multiplex sandwich ELISAs in a planar or bead-based format to the more expanded antibody arrays employing direct sample labeling. The plethora of data generated from these arrays could be of great interest to understand a complex disorder such as endometriosis. Multiplex immunoassay analysis may provide information on disease pathology and may lead to improved, timely diagnosis. Until now, the use of multiplex immunoassays has been limited in endometriosis. With the constant development of multiplex technologies, future studies should focus on implementing these techniques, and combining them with multivariate statistical analysis. In this review, we provide an overview of multiplex immunoassay methods used in endometriosis studies and the data sets acquired by these methodologies. These data and future studies might provide novel insights for biomarker discovery and investigation of the pathogenesis in endometriosis. SN - 1093-4715 UR - https://www.unboundmedicine.com/medline/citation/27814626/Multiplex_immunoassays_in_endometriosis:_An_array_of_possibilities_ L2 - https://www.bioscience.org/2017/v22/af/4496/fulltext.htm DB - PRIME DP - Unbound Medicine ER -