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Chronic obstructive pulmonary disease in Welsh slate miners.
Occup Med (Lond). 2017 Jan; 67(1):20-25.OM

Abstract

BACKGROUND

Exposure to respirable crystalline silica (RCS) causes emphysema, airflow limitation and chronic obstructive pulmonary disease (COPD). Slate miners are exposed to slate dust containing RCS but their COPD risk has not previously been studied.

AIMS

To study the cumulative effect of mining on lung function and risk of COPD in a cohort of Welsh slate miners and whether these were independent of smoking and pneumoconiosis.

METHODS

The study was based on a secondary analysis of Medical Research Council (MRC) survey data. COPD was defined as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) ratio <0.7. We created multivariable models to assess the association between mining and lung function after adjusting for age and smoking status. We used linear regression models for FEV1 and FVC and logistic regression for COPD.

RESULTS

In the original MRC study, 1255 men participated (726 slate miners, 529 unexposed non-miners). COPD was significantly more common in miners (n = 213, 33%) than non-miners (n = 120, 26%), P < 0.05. There was no statistically significant difference in risk of COPD between miners and non-miners when analysis was limited to non-smokers or those without radiographic evidence of pneumoconiosis. After adjustment for smoking, slate mining was associated with a reduction in %predicted FEV1 [β coefficient = -3.97, 95% confidence interval (CI) -6.65, -1.29] and FVC (β coefficient = -2.32, 95% CI -4.31, -0.33) and increased risk of COPD (odds ratio: 1.38, 95% CI 1.06, 1.81).

CONCLUSIONS

Slate mining may reduce lung function and increase the incidence of COPD independently of smoking and pneumoconiosis.

Authors+Show Affiliations

National Heart and Lung Institute, Imperial College London, London SW3 6LR, UK, carl.reynolds@imperial.ac.uk.School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK.School of Health and Related Research, University of Sheffield, Sheffield S1 4DA, UK.School of Health and Related Research, University of Sheffield, Sheffield S1 4DA, UK.School of Health and Related Research, University of Sheffield, Sheffield S1 4DA, UK.National Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.National Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27816911

Citation

Reynolds, C J., et al. "Chronic Obstructive Pulmonary Disease in Welsh Slate Miners." Occupational Medicine (Oxford, England), vol. 67, no. 1, 2017, pp. 20-25.
Reynolds CJ, MacNeill SJ, Williams J, et al. Chronic obstructive pulmonary disease in Welsh slate miners. Occup Med (Lond). 2017;67(1):20-25.
Reynolds, C. J., MacNeill, S. J., Williams, J., Hodges, N. G., Campbell, M. J., Newman Taylor, A. J., & Cullinan, P. (2017). Chronic obstructive pulmonary disease in Welsh slate miners. Occupational Medicine (Oxford, England), 67(1), 20-25. https://doi.org/10.1093/occmed/kqw147
Reynolds CJ, et al. Chronic Obstructive Pulmonary Disease in Welsh Slate Miners. Occup Med (Lond). 2017;67(1):20-25. PubMed PMID: 27816911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic obstructive pulmonary disease in Welsh slate miners. AU - Reynolds,C J, AU - MacNeill,S J, AU - Williams,J, AU - Hodges,N G, AU - Campbell,M J, AU - Newman Taylor,A J, AU - Cullinan,P, Y1 - 2016/11/05/ PY - 2016/11/7/pubmed PY - 2017/9/13/medline PY - 2016/11/7/entrez KW - Mineral dust KW - miners KW - occupational lung diseases. SP - 20 EP - 25 JF - Occupational medicine (Oxford, England) JO - Occup Med (Lond) VL - 67 IS - 1 N2 - BACKGROUND: Exposure to respirable crystalline silica (RCS) causes emphysema, airflow limitation and chronic obstructive pulmonary disease (COPD). Slate miners are exposed to slate dust containing RCS but their COPD risk has not previously been studied. AIMS: To study the cumulative effect of mining on lung function and risk of COPD in a cohort of Welsh slate miners and whether these were independent of smoking and pneumoconiosis. METHODS: The study was based on a secondary analysis of Medical Research Council (MRC) survey data. COPD was defined as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) ratio <0.7. We created multivariable models to assess the association between mining and lung function after adjusting for age and smoking status. We used linear regression models for FEV1 and FVC and logistic regression for COPD. RESULTS: In the original MRC study, 1255 men participated (726 slate miners, 529 unexposed non-miners). COPD was significantly more common in miners (n = 213, 33%) than non-miners (n = 120, 26%), P < 0.05. There was no statistically significant difference in risk of COPD between miners and non-miners when analysis was limited to non-smokers or those without radiographic evidence of pneumoconiosis. After adjustment for smoking, slate mining was associated with a reduction in %predicted FEV1 [β coefficient = -3.97, 95% confidence interval (CI) -6.65, -1.29] and FVC (β coefficient = -2.32, 95% CI -4.31, -0.33) and increased risk of COPD (odds ratio: 1.38, 95% CI 1.06, 1.81). CONCLUSIONS: Slate mining may reduce lung function and increase the incidence of COPD independently of smoking and pneumoconiosis. SN - 1471-8405 UR - https://www.unboundmedicine.com/medline/citation/27816911/Chronic_obstructive_pulmonary_disease_in_Welsh_slate_miners_ L2 - https://academic.oup.com/occmed/article-lookup/doi/10.1093/occmed/kqw147 DB - PRIME DP - Unbound Medicine ER -