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Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome.
Vaccine. 2016 12 07; 34(50):6316-6322.V

Abstract

OBJECTIVE

Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people.

METHODS

A case-crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3days prior to the ACS diagnosis date were retrieved from the data banks of the Taiwan Environmental Protection Administration and Central Weather Bureau.

FINDINGS

Increases in air pollution concentrations of CO, NO2, PM10 or PM2.5 and decreases in temperature significantly influenced the risk of ACS for the non-continuously vaccinated elderly population; however, less significant effects were observed for the continuously vaccinated population.

CONCLUSION

Consecutive influenza vaccination may potentially offer resistance against the detrimental effects of air pollution and changes in temperature in frail elderly adults with ACS. Future studies are needed to directly assess the interaction effect between the vaccination and environmental factors on ACS.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; Institute of Statistics and Information Science, National Changhua University of Education, Taiwan. Electronic address: chinghui@cch.org.tw.Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan. Electronic address: dychao@nchu.edu.tw.Public Health Bureau, Yunlin County, Taiwan. Electronic address: iblian@ibms.sinica.edu.tw.Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan; Public Health Bureau, Yunlin County, Taiwan. Electronic address: yls007@ylshb.gov.tw.Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan. Electronic address: 28071@cch.org.tw.Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Chung-Shan Medical University, Taichung, Taiwan. Electronic address: chiachu@cch.org.tw.Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan. Electronic address: 179297@cch.org.tw.Institute of Statistics and Information Science, National Changhua University of Education, Taiwan. Electronic address: j102858@cc.ncue.edu.tw.Institute of Statistics and Information Science, National Changhua University of Education, Taiwan. Electronic address: maiblian@cc.ncue.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27823899

Citation

Huang, Ching-Hui, et al. "Influenza Vaccination and the Endurance Against Air Pollution Among Elderly With Acute Coronary Syndrome." Vaccine, vol. 34, no. 50, 2016, pp. 6316-6322.
Huang CH, Chao DY, Wu CC, et al. Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome. Vaccine. 2016;34(50):6316-6322.
Huang, C. H., Chao, D. Y., Wu, C. C., Hsu, S. Y., Soon, M. S., Chang, C. C., Kor, C. T., Chang, W. T., & Lian, I. B. (2016). Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome. Vaccine, 34(50), 6316-6322. https://doi.org/10.1016/j.vaccine.2016.10.054
Huang CH, et al. Influenza Vaccination and the Endurance Against Air Pollution Among Elderly With Acute Coronary Syndrome. Vaccine. 2016 12 7;34(50):6316-6322. PubMed PMID: 27823899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome. AU - Huang,Ching-Hui, AU - Chao,Day-Yu, AU - Wu,Chao-Chun, AU - Hsu,Shu-Yun, AU - Soon,Maw-Soan, AU - Chang,Chia-Chu, AU - Kor,Chew-Teng, AU - Chang,Wan-Tzu, AU - Lian,Ie-Bin, Y1 - 2016/11/04/ PY - 2016/06/13/received PY - 2016/10/07/revised PY - 2016/10/21/accepted PY - 2016/11/9/pubmed PY - 2017/12/16/medline PY - 2016/11/9/entrez KW - Acute coronary syndrome KW - Air pollution KW - Case–crossover KW - Influenza vaccine KW - Meteorology SP - 6316 EP - 6322 JF - Vaccine JO - Vaccine VL - 34 IS - 50 N2 - OBJECTIVE: Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. METHODS: A case-crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3days prior to the ACS diagnosis date were retrieved from the data banks of the Taiwan Environmental Protection Administration and Central Weather Bureau. FINDINGS: Increases in air pollution concentrations of CO, NO2, PM10 or PM2.5 and decreases in temperature significantly influenced the risk of ACS for the non-continuously vaccinated elderly population; however, less significant effects were observed for the continuously vaccinated population. CONCLUSION: Consecutive influenza vaccination may potentially offer resistance against the detrimental effects of air pollution and changes in temperature in frail elderly adults with ACS. Future studies are needed to directly assess the interaction effect between the vaccination and environmental factors on ACS. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/27823899/Influenza_vaccination_and_the_endurance_against_air_pollution_among_elderly_with_acute_coronary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(16)30989-6 DB - PRIME DP - Unbound Medicine ER -