Tags

Type your tag names separated by a space and hit enter

Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients.
J Formos Med Assoc. 2017 Feb; 116(2):99-106.JF

Abstract

BACKGROUND/PURPOSE

Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs-/RAS) patients.

METHODS

The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs-/RAS patients, and 342 healthy control subjects.

RESULTS

GPCA+/RAS patients had significantly lower mean Hb and serum iron level (for women only) as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/RAS patients had a significantly higher MCV and a significantly greater frequency of vitamin B12 deficiency than Abs-/RAS patients. Furthermore, Abs-/RAS patients did have significantly lower mean Hb, MCV, iron, and folic acid levels and significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Of 31 GPCA+/RAS patients, 3 (9.7%) had PA, 6 (19.4%) had vitamin B12 deficiency, and 3 (9.7%) had macrocytosis. Moreover, normocytic anemia (54.0%) and iron deficiency anemia (26.4%) are the two more common types of anemia in our RAS patients.

CONCLUSIONS

We conclude that serum GPCA plays a significant role in causing vitamin B12 deficiency and high MCV in GPCA+/RAS patients. RAS itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA+/RAS and Abs-/RAS patients.

Authors+Show Affiliations

Department of Dentistry, MacKay Memorial Hospital, Taipei, Taiwan; School of Dentistry and Graduate Institute of Dental Sciences, China Medical University, Taichung, Taiwan; School of Dentistry, Taipei Medical University, Taipei, Taiwan; School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27825815

Citation

Lin, Hung-Pin, et al. "Anemia and Hematinic Deficiencies in Anti-gastric Parietal Cell Antibody-positive or All Autoantibodies-negative Recurrent Aphthous Stomatitis Patients." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 116, no. 2, 2017, pp. 99-106.
Lin HP, Wu YH, Wang YP, et al. Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients. J Formos Med Assoc. 2017;116(2):99-106.
Lin, H. P., Wu, Y. H., Wang, Y. P., Wu, Y. C., Chang, J. Y., & Sun, A. (2017). Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 116(2), 99-106. https://doi.org/10.1016/j.jfma.2016.10.006
Lin HP, et al. Anemia and Hematinic Deficiencies in Anti-gastric Parietal Cell Antibody-positive or All Autoantibodies-negative Recurrent Aphthous Stomatitis Patients. J Formos Med Assoc. 2017;116(2):99-106. PubMed PMID: 27825815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients. AU - Lin,Hung-Pin, AU - Wu,Yu-Hsueh, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Chang,Julia Yu-Fong, AU - Sun,Andy, Y1 - 2016/11/05/ PY - 2016/10/07/received PY - 2016/10/09/accepted PY - 2016/11/9/pubmed PY - 2017/9/12/medline PY - 2016/11/10/entrez KW - Anemia KW - Anti-gastric parietal cell antibody KW - Iron KW - Macrocytosis KW - Recurrent aphthous stomatitis KW - Vitamin B12 deficiency SP - 99 EP - 106 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 116 IS - 2 N2 - BACKGROUND/PURPOSE: Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs-/RAS) patients. METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs-/RAS patients, and 342 healthy control subjects. RESULTS: GPCA+/RAS patients had significantly lower mean Hb and serum iron level (for women only) as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/RAS patients had a significantly higher MCV and a significantly greater frequency of vitamin B12 deficiency than Abs-/RAS patients. Furthermore, Abs-/RAS patients did have significantly lower mean Hb, MCV, iron, and folic acid levels and significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Of 31 GPCA+/RAS patients, 3 (9.7%) had PA, 6 (19.4%) had vitamin B12 deficiency, and 3 (9.7%) had macrocytosis. Moreover, normocytic anemia (54.0%) and iron deficiency anemia (26.4%) are the two more common types of anemia in our RAS patients. CONCLUSIONS: We conclude that serum GPCA plays a significant role in causing vitamin B12 deficiency and high MCV in GPCA+/RAS patients. RAS itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA+/RAS and Abs-/RAS patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/27825815/Anemia_and_hematinic_deficiencies_in_anti_gastric_parietal_cell_antibody_positive_or_all_autoantibodies_negative_recurrent_aphthous_stomatitis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(16)30268-6 DB - PRIME DP - Unbound Medicine ER -