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Growth and BMI during the first 14 y of life in offspring from women with type 1 or type 2 diabetes mellitus.
Pediatr Res. 2017 02; 81(2):342-348.PR

Abstract

BACKGROUND

Infants of women with pregestational diabetes are at risk for developing obesity in later life. This study aimed to identify subgroups at highest risk, by studying growth profiles of offspring from women with type 1 or 2 diabetes mellitus (ODM1, ODM2) until the age of 14 y.

METHODS

Information from infant welfare centers was received for 78 ODM1 and 44 ODM2. Mean BMI SD scores (SDS) (based on 1980 nation-wide references) and height SDS (based on 2009 references) were calculated and included in a random-effects model. Values were compared to the 2009 Dutch growth study.

RESULTS

BMI SDS profiles differed between ODM1 and ODM2, with the highest mean BMI SDS profiles in ODM2. Other factors that affected growth profiles in these infants included the presence of maternal obesity, large for gestational age (LGA) at birth and in ODM2 a Dutch-Mediterranean origin.

CONCLUSION

Offspring of women with diabetes have higher BMI SDS profiles than observed in the 2009 Dutch growth study, with the highest BMI SDS in ODM2 who are LGA at birth and have obese mothers. Preventive strategies for offspring adiposity may include pursuing lower prepregnancy maternal BMI, prevention of LGA at birth, and prevention of increased weight gain during childhood.

Authors+Show Affiliations

Department of Obstetrics, Division Woman & Baby, the University Medical Center Utrecht, Utrecht, The Netherlands. Department of Internal medicine and infectious diseases, the University Medical Center Utrecht, Utrecht, The Netherlands.Department of Internal medicine and infectious diseases, the University Medical Center Utrecht, Utrecht, The Netherlands.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Internal medicine and infectious diseases, the University Medical Center Utrecht, Utrecht, The Netherlands.Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.Department of Obstetrics, Division Woman & Baby, the University Medical Center Utrecht, Utrecht, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27828938

Citation

Hammoud, Nurah M., et al. "Growth and BMI During the First 14 Y of Life in Offspring From Women With Type 1 or Type 2 Diabetes Mellitus." Pediatric Research, vol. 81, no. 2, 2017, pp. 342-348.
Hammoud NM, de Valk HW, van Rossem L, et al. Growth and BMI during the first 14 y of life in offspring from women with type 1 or type 2 diabetes mellitus. Pediatr Res. 2017;81(2):342-348.
Hammoud, N. M., de Valk, H. W., van Rossem, L., Biesma, D. H., Wit, J. M., & Visser, G. H. (2017). Growth and BMI during the first 14 y of life in offspring from women with type 1 or type 2 diabetes mellitus. Pediatric Research, 81(2), 342-348. https://doi.org/10.1038/pr.2016.236
Hammoud NM, et al. Growth and BMI During the First 14 Y of Life in Offspring From Women With Type 1 or Type 2 Diabetes Mellitus. Pediatr Res. 2017;81(2):342-348. PubMed PMID: 27828938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth and BMI during the first 14 y of life in offspring from women with type 1 or type 2 diabetes mellitus. AU - Hammoud,Nurah M, AU - de Valk,Harold W, AU - van Rossem,Lenie, AU - Biesma,Douwe H, AU - Wit,Jan M, AU - Visser,Gerard H A, Y1 - 2016/11/09/ PY - 2016/05/20/received PY - 2016/08/30/accepted PY - 2016/11/10/pubmed PY - 2017/11/29/medline PY - 2016/11/10/entrez SP - 342 EP - 348 JF - Pediatric research JO - Pediatr Res VL - 81 IS - 2 N2 - BACKGROUND: Infants of women with pregestational diabetes are at risk for developing obesity in later life. This study aimed to identify subgroups at highest risk, by studying growth profiles of offspring from women with type 1 or 2 diabetes mellitus (ODM1, ODM2) until the age of 14 y. METHODS: Information from infant welfare centers was received for 78 ODM1 and 44 ODM2. Mean BMI SD scores (SDS) (based on 1980 nation-wide references) and height SDS (based on 2009 references) were calculated and included in a random-effects model. Values were compared to the 2009 Dutch growth study. RESULTS: BMI SDS profiles differed between ODM1 and ODM2, with the highest mean BMI SDS profiles in ODM2. Other factors that affected growth profiles in these infants included the presence of maternal obesity, large for gestational age (LGA) at birth and in ODM2 a Dutch-Mediterranean origin. CONCLUSION: Offspring of women with diabetes have higher BMI SDS profiles than observed in the 2009 Dutch growth study, with the highest BMI SDS in ODM2 who are LGA at birth and have obese mothers. Preventive strategies for offspring adiposity may include pursuing lower prepregnancy maternal BMI, prevention of LGA at birth, and prevention of increased weight gain during childhood. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/27828938/Growth_and_BMI_during_the_first_14_y_of_life_in_offspring_from_women_with_type_1_or_type_2_diabetes_mellitus_ L2 - https://doi.org/10.1038/pr.2016.236 DB - PRIME DP - Unbound Medicine ER -