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The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials.
Neurol Sci. 2017 Feb; 38(2):215-224.NS

Abstract

The objective of this meta-analysis was to evaluate the effects of coenzyme Q10 (CoQ10) for the treatment of Parkinson's disease (PD) patients in order to arrive at qualitative and quantitative conclusions about the efficacy of CoQ10. Databases searched included PubMed, Google scholar, CNKI, Wan-Fang, and the Cochrane Library from inception to March 2016. We only included sham-controlled, randomized clinical trials of CoQ10 intervention for motor dysfunction in patients with PD. Relevant measures were extracted independently by two investigators. Weighted mean differences (WMD) were calculated with random-effects models. Eight studies with a total of 899 patients were included. Random-effects analysis revealed a pooled WMD of 1.02, indicating no significant difference when CoQ10 treatment compared with placebo in terms of UPDRS part 3 (p = 0.54). Meanwhile, the effect size of UPDRS part 1, UPDRS part 2, and total UPDRS scores were similar in CoQ10 group with in placebo group (p > 0.05). Moreover, we found CoQ10 was well tolerated compared with placebo group. Subgroup analysis showed that the effect size of CoQ10 in monocentric studies was larger than in multicenter studies. Using the GRADE criteria, we characterized the quality of evidence presented in this meta-analysis as moderate to high level. The current meta-analysis provided evidence that CoQ10 was safe and well tolerated in participants with PD and no superior to placebo in terms of motor symptoms. According to these results, we cannot recommend CoQ10 for the routine treatment of PD right now.

Authors+Show Affiliations

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.The Center of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 35000, China.Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.The Center of Traditional Chinese Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.Department of Pediatric Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. 69365560@qq.com.Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. xiechenglong1987@sina.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27830343

Citation

Zhu, Zhen-Guo, et al. "The Efficacy and Safety of Coenzyme Q10 in Parkinson's Disease: a Meta-analysis of Randomized Controlled Trials." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 38, no. 2, 2017, pp. 215-224.
Zhu ZG, Sun MX, Zhang WL, et al. The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Neurol Sci. 2017;38(2):215-224.
Zhu, Z. G., Sun, M. X., Zhang, W. L., Wang, W. W., Jin, Y. M., & Xie, C. L. (2017). The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 38(2), 215-224. https://doi.org/10.1007/s10072-016-2757-9
Zhu ZG, et al. The Efficacy and Safety of Coenzyme Q10 in Parkinson's Disease: a Meta-analysis of Randomized Controlled Trials. Neurol Sci. 2017;38(2):215-224. PubMed PMID: 27830343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. AU - Zhu,Zhen-Guo, AU - Sun,Miao-Xuan, AU - Zhang,Wan-Li, AU - Wang,Wen-Wen, AU - Jin,Yi-Mei, AU - Xie,Cheng-Long, Y1 - 2016/11/09/ PY - 2016/08/12/received PY - 2016/10/27/accepted PY - 2016/11/11/pubmed PY - 2017/2/28/medline PY - 2016/11/11/entrez KW - CoQ10 KW - Coenzyme Q10 KW - Meta-analysis KW - Parkinson’s disease SP - 215 EP - 224 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 38 IS - 2 N2 - The objective of this meta-analysis was to evaluate the effects of coenzyme Q10 (CoQ10) for the treatment of Parkinson's disease (PD) patients in order to arrive at qualitative and quantitative conclusions about the efficacy of CoQ10. Databases searched included PubMed, Google scholar, CNKI, Wan-Fang, and the Cochrane Library from inception to March 2016. We only included sham-controlled, randomized clinical trials of CoQ10 intervention for motor dysfunction in patients with PD. Relevant measures were extracted independently by two investigators. Weighted mean differences (WMD) were calculated with random-effects models. Eight studies with a total of 899 patients were included. Random-effects analysis revealed a pooled WMD of 1.02, indicating no significant difference when CoQ10 treatment compared with placebo in terms of UPDRS part 3 (p = 0.54). Meanwhile, the effect size of UPDRS part 1, UPDRS part 2, and total UPDRS scores were similar in CoQ10 group with in placebo group (p > 0.05). Moreover, we found CoQ10 was well tolerated compared with placebo group. Subgroup analysis showed that the effect size of CoQ10 in monocentric studies was larger than in multicenter studies. Using the GRADE criteria, we characterized the quality of evidence presented in this meta-analysis as moderate to high level. The current meta-analysis provided evidence that CoQ10 was safe and well tolerated in participants with PD and no superior to placebo in terms of motor symptoms. According to these results, we cannot recommend CoQ10 for the routine treatment of PD right now. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/27830343/The_efficacy_and_safety_of_coenzyme_Q10_in_Parkinson's_disease:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://link.springer.com/10.1007/s10072-016-2757-9 DB - PRIME DP - Unbound Medicine ER -