Tags

Type your tag names separated by a space and hit enter

Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease.
J Immunol 1989; 142(2):471-80JI

Abstract

Cyclosporin A (CsA), a potent immunosuppressive drug, caused organ-specific autoimmune disease, such as gastritis with anti-parietal cell autoantibodies or oophoritis with anti-oocyte autoantibodies, in BALB/c mice when the drug was administered daily for 1 wk to newborns. Administration to adult mice did not. CsA abrogated the production of L3T4+ T cells and Lyt-2+ T cells in the thymus. Consequently, these T cells were substantially depleted from the peripheral lymphoid organs, especially when the drug was administered from the day of birth. Autoimmune disease was prevented when CsA-treated newborn mice were inoculated with splenic T cells from normal syngeneic mice. However, removal of the thymus immediately after neonatal CsA treatment produced autoimmune disease with a higher incidence and in a wider spectrum of organs, i.e., thyroiditis, sialoadenitis of the salivary gland, gastritis, insulitis of the endocrine pancreas, adrenalitis, oophoritis, or orchitis. Each autoimmune disease was accompanied by the development of circulating autoantibodies specific for the corresponding organ Ag. Immunopathology of these autoimmune diseases was quite similar to that of human organ-specific autoimmune diseases.

Authors+Show Affiliations

Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2783437

Citation

Sakaguchi, S, and N Sakaguchi. "Organ-specific Autoimmune Disease Induced in Mice By Elimination of T Cell Subsets. V. Neonatal Administration of Cyclosporin a Causes Autoimmune Disease." Journal of Immunology (Baltimore, Md. : 1950), vol. 142, no. 2, 1989, pp. 471-80.
Sakaguchi S, Sakaguchi N. Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J Immunol. 1989;142(2):471-80.
Sakaguchi, S., & Sakaguchi, N. (1989). Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. Journal of Immunology (Baltimore, Md. : 1950), 142(2), pp. 471-80.
Sakaguchi S, Sakaguchi N. Organ-specific Autoimmune Disease Induced in Mice By Elimination of T Cell Subsets. V. Neonatal Administration of Cyclosporin a Causes Autoimmune Disease. J Immunol. 1989 Jan 15;142(2):471-80. PubMed PMID: 2783437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. AU - Sakaguchi,S, AU - Sakaguchi,N, PY - 1989/1/15/pubmed PY - 1989/1/15/medline PY - 1989/1/15/entrez SP - 471 EP - 80 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 142 IS - 2 N2 - Cyclosporin A (CsA), a potent immunosuppressive drug, caused organ-specific autoimmune disease, such as gastritis with anti-parietal cell autoantibodies or oophoritis with anti-oocyte autoantibodies, in BALB/c mice when the drug was administered daily for 1 wk to newborns. Administration to adult mice did not. CsA abrogated the production of L3T4+ T cells and Lyt-2+ T cells in the thymus. Consequently, these T cells were substantially depleted from the peripheral lymphoid organs, especially when the drug was administered from the day of birth. Autoimmune disease was prevented when CsA-treated newborn mice were inoculated with splenic T cells from normal syngeneic mice. However, removal of the thymus immediately after neonatal CsA treatment produced autoimmune disease with a higher incidence and in a wider spectrum of organs, i.e., thyroiditis, sialoadenitis of the salivary gland, gastritis, insulitis of the endocrine pancreas, adrenalitis, oophoritis, or orchitis. Each autoimmune disease was accompanied by the development of circulating autoantibodies specific for the corresponding organ Ag. Immunopathology of these autoimmune diseases was quite similar to that of human organ-specific autoimmune diseases. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/2783437/Organ_specific_autoimmune_disease_induced_in_mice_by_elimination_of_T_cell_subsets__V__Neonatal_administration_of_cyclosporin_A_causes_autoimmune_disease_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2783437 DB - PRIME DP - Unbound Medicine ER -