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Transient Receptor Potential Channels in neuropathic pain.
Curr Opin Pharmacol. 2017 02; 32:9-15.CO

Abstract

Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system. The detection of these stimuli depends on the TRP ion channel family, which activates upon damaging pressure, extreme temperature, or toxic endogenous and exogenous chemicals. This review will summarize the current knowledge of the contribution of TRP channels, particularly the thermosensitive TRP, including TRPV1, TRPA1 and TRPM8 channels that play a central role in the sensitization of nociceptive transduction. We will discuss the pharmacology of these receptors and their relative success in preclinical and clinical studies.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada.Department of Physiology and Pharmacology, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada. Electronic address: altier@ucalgary.ca.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27835802

Citation

Basso, Lilian, and Christophe Altier. "Transient Receptor Potential Channels in Neuropathic Pain." Current Opinion in Pharmacology, vol. 32, 2017, pp. 9-15.
Basso L, Altier C. Transient Receptor Potential Channels in neuropathic pain. Curr Opin Pharmacol. 2017;32:9-15.
Basso, L., & Altier, C. (2017). Transient Receptor Potential Channels in neuropathic pain. Current Opinion in Pharmacology, 32, 9-15. https://doi.org/10.1016/j.coph.2016.10.002
Basso L, Altier C. Transient Receptor Potential Channels in Neuropathic Pain. Curr Opin Pharmacol. 2017;32:9-15. PubMed PMID: 27835802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transient Receptor Potential Channels in neuropathic pain. AU - Basso,Lilian, AU - Altier,Christophe, Y1 - 2016/10/27/ PY - 2016/08/04/received PY - 2016/10/06/revised PY - 2016/10/10/accepted PY - 2016/11/12/pubmed PY - 2017/8/5/medline PY - 2016/11/12/entrez SP - 9 EP - 15 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 32 N2 - Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system. The detection of these stimuli depends on the TRP ion channel family, which activates upon damaging pressure, extreme temperature, or toxic endogenous and exogenous chemicals. This review will summarize the current knowledge of the contribution of TRP channels, particularly the thermosensitive TRP, including TRPV1, TRPA1 and TRPM8 channels that play a central role in the sensitization of nociceptive transduction. We will discuss the pharmacology of these receptors and their relative success in preclinical and clinical studies. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/27835802/Transient_Receptor_Potential_Channels_in_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(16)30122-9 DB - PRIME DP - Unbound Medicine ER -