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Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in elderly community residents.
Int J Cardiol 2017; 227:820-825IJ

Abstract

BACKGROUND

Left ventricular diastolic dysfunction (LVDD) is closely related to heart failure with preserved ejection fraction (HFpEF), while the prevalence and correlates of either LVDD or HFpEF in elderly population remain largely unknown.

METHODS

The study was performed in 1274 community residents (769 women, aged ≥65years) who participated in the Shanghai Heart Health Study. Demographic, laboratory and echocardiographic data were obtained to analyze correlates of LVDD and HFpEF using univariate and multivariate Logistic analysis.

RESULTS

LVDD was detected in 31.9% (406/1274) residents and it was significantly higher in women than in men (34.2% vs. 28.3%, P=0.027). HFpEF prevalence was 2.8% (35/1274), and increased with aging in the whole cohort. For residents with left ventricular ejection fraction ≥50% and normal-sized ventricular cavity, female sex (odds ratio [OR] 1.69, 95% confidence interval [CI] 1.24-2.29), heart rate (OR 0.76, 95% CI 0.68-0.86), atrial fibrillation (OR 7.37, 95% CI 3.13-17.36), hypertension (OR 1.32, 95% CI 1.00-1.75), N-terminal pro-B type natriuretic peptide (OR 2.33, 95% CI 1.50-3.61) and high-sensitivity troponin T (hs-TnT) (OR 1.90, 95% CI 1.12-3.23) were independent correlates of asymptomatic LVDD. While age (OR 1.44, 95% CI 1.01-2.06), heart rate (OR 0.66, 95% CI 0.47-0.93) and hs-TnT (OR 4.37, 95% CI 1.46-13.12) were independently related to HFpEF.

CONCLUSIONS

LVDD is common in this community elderly population, and HFpEF is also not rare. Different factors played roles in different stages of HFpEF. Future studies are warranted to explore the predictors of LVDD and HFpEF in the community elderly.

Authors+Show Affiliations

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.Section of Cardiology, Department of Medicine, Sahlgrenska University Hospital/Östra Hospital, University of Gothenburg, 41345 Gothenburg, Sweden.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: jbge@zs-hospital.sh.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27836303

Citation

Cui, Xiaotong, et al. "Prevalence and Correlates of Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction in Elderly Community Residents." International Journal of Cardiology, vol. 227, 2017, pp. 820-825.
Cui X, Zhou J, Jin X, et al. Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in elderly community residents. Int J Cardiol. 2017;227:820-825.
Cui, X., Zhou, J., Jin, X., Zhou, J., Fu, M., Hu, K., ... Ge, J. (2017). Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in elderly community residents. International Journal of Cardiology, 227, pp. 820-825. doi:10.1016/j.ijcard.2016.10.041.
Cui X, et al. Prevalence and Correlates of Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction in Elderly Community Residents. Int J Cardiol. 2017 Jan 15;227:820-825. PubMed PMID: 27836303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in elderly community residents. AU - Cui,Xiaotong, AU - Zhou,Jingmin, AU - Jin,Xuejuan, AU - Zhou,Jun, AU - Fu,Michael, AU - Hu,Kai, AU - Sun,Aijun, AU - Ge,Junbo, Y1 - 2016/10/17/ PY - 2016/06/07/received PY - 2016/10/10/revised PY - 2016/10/14/accepted PY - 2016/11/12/pubmed PY - 2017/11/9/medline PY - 2016/11/13/entrez KW - Diastolic dysfunction KW - Elderly KW - Epidemiology KW - Heart failure KW - Preserved ejection fraction SP - 820 EP - 825 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 227 N2 - BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is closely related to heart failure with preserved ejection fraction (HFpEF), while the prevalence and correlates of either LVDD or HFpEF in elderly population remain largely unknown. METHODS: The study was performed in 1274 community residents (769 women, aged ≥65years) who participated in the Shanghai Heart Health Study. Demographic, laboratory and echocardiographic data were obtained to analyze correlates of LVDD and HFpEF using univariate and multivariate Logistic analysis. RESULTS: LVDD was detected in 31.9% (406/1274) residents and it was significantly higher in women than in men (34.2% vs. 28.3%, P=0.027). HFpEF prevalence was 2.8% (35/1274), and increased with aging in the whole cohort. For residents with left ventricular ejection fraction ≥50% and normal-sized ventricular cavity, female sex (odds ratio [OR] 1.69, 95% confidence interval [CI] 1.24-2.29), heart rate (OR 0.76, 95% CI 0.68-0.86), atrial fibrillation (OR 7.37, 95% CI 3.13-17.36), hypertension (OR 1.32, 95% CI 1.00-1.75), N-terminal pro-B type natriuretic peptide (OR 2.33, 95% CI 1.50-3.61) and high-sensitivity troponin T (hs-TnT) (OR 1.90, 95% CI 1.12-3.23) were independent correlates of asymptomatic LVDD. While age (OR 1.44, 95% CI 1.01-2.06), heart rate (OR 0.66, 95% CI 0.47-0.93) and hs-TnT (OR 4.37, 95% CI 1.46-13.12) were independently related to HFpEF. CONCLUSIONS: LVDD is common in this community elderly population, and HFpEF is also not rare. Different factors played roles in different stages of HFpEF. Future studies are warranted to explore the predictors of LVDD and HFpEF in the community elderly. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/27836303/Prevalence_and_correlates_of_left_ventricular_diastolic_dysfunction_and_heart_failure_with_preserved_ejection_fraction_in_elderly_community_residents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(16)33012-1 DB - PRIME DP - Unbound Medicine ER -