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Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity.
Biomed Pharmacother. 2016 Dec; 84:1717-1726.BP

Abstract

Naringin, plant bioflavonoid extracted mainly from grapefruit and other related citrus species. This study was designed to assess the neuroprotective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitonial injection (i.p) of NH4Cl (100mg/kg body weight (b.w.)) thrice a week for 8 consecutive weeks. Hyperammonemic rats were treated with naringin (80mg/kg b.w.) via oral gavage. Naringin administration drastically restored the levels of blood ammonia, plasma urea, nitric oxide (NO), glutamate, glutamine, lipid peroxidation, lipid profile, activities of liver marker enzymes, antioxidant status and sodium/potassium-ATPase (Na+/K+-ATPase). In addition, naringin supplementation reverted back the pathological changes of liver, brain and kidney tissues, the expressions of Glutamine synthetase (GS), Na+/K+-ATPase, neuronal nitric oxide (nNOS) and soluble guanylate cyclase (sGC) in hyperammonemic rats. Hence, this study suggested that nargingin exhibited their protective effect against NH4Cl induced toxicity via enhancing the activities of antioxidant enzymes and inhibiting the lipid peroxidation process. Take together, this study provides data that naingin effectively reduced neurotoxicity by attenuating hyperammonemia, suggesting that naringin act as a potential therapeutic agent to treat hyperammonemic rats.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, India.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, India. Electronic address: nvkbiochem@yahoo.co.in.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27836465

Citation

Ramakrishnan, Arumugam, et al. "Naringin Regulates Glutamate-nitric Oxide cGMP Pathway in Ammonium Chloride Induced Neurotoxicity." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 84, 2016, pp. 1717-1726.
Ramakrishnan A, Vijayakumar N, Renuka M. Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity. Biomed Pharmacother. 2016;84:1717-1726.
Ramakrishnan, A., Vijayakumar, N., & Renuka, M. (2016). Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 84, 1717-1726. https://doi.org/10.1016/j.biopha.2016.10.080
Ramakrishnan A, Vijayakumar N, Renuka M. Naringin Regulates Glutamate-nitric Oxide cGMP Pathway in Ammonium Chloride Induced Neurotoxicity. Biomed Pharmacother. 2016;84:1717-1726. PubMed PMID: 27836465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity. AU - Ramakrishnan,Arumugam, AU - Vijayakumar,Natesan, AU - Renuka,Mani, Y1 - 2016/11/09/ PY - 2016/07/06/received PY - 2016/10/27/revised PY - 2016/10/27/accepted PY - 2016/11/12/pubmed PY - 2017/2/14/medline PY - 2016/11/13/entrez KW - Antioxidant status KW - Genomic profile KW - Hyperammonemia KW - Lipid profile KW - Naringin SP - 1717 EP - 1726 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 84 N2 - Naringin, plant bioflavonoid extracted mainly from grapefruit and other related citrus species. This study was designed to assess the neuroprotective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitonial injection (i.p) of NH4Cl (100mg/kg body weight (b.w.)) thrice a week for 8 consecutive weeks. Hyperammonemic rats were treated with naringin (80mg/kg b.w.) via oral gavage. Naringin administration drastically restored the levels of blood ammonia, plasma urea, nitric oxide (NO), glutamate, glutamine, lipid peroxidation, lipid profile, activities of liver marker enzymes, antioxidant status and sodium/potassium-ATPase (Na+/K+-ATPase). In addition, naringin supplementation reverted back the pathological changes of liver, brain and kidney tissues, the expressions of Glutamine synthetase (GS), Na+/K+-ATPase, neuronal nitric oxide (nNOS) and soluble guanylate cyclase (sGC) in hyperammonemic rats. Hence, this study suggested that nargingin exhibited their protective effect against NH4Cl induced toxicity via enhancing the activities of antioxidant enzymes and inhibiting the lipid peroxidation process. Take together, this study provides data that naingin effectively reduced neurotoxicity by attenuating hyperammonemia, suggesting that naringin act as a potential therapeutic agent to treat hyperammonemic rats. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/27836465/Naringin_regulates_glutamate_nitric_oxide_cGMP_pathway_in_ammonium_chloride_induced_neurotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(16)31014-9 DB - PRIME DP - Unbound Medicine ER -