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Visceral adiposity index levels in overweight and/or obese, and non-obese patients with polycystic ovary syndrome and its relationship with metabolic and inflammatory parameters.
J Endocrinol Invest. 2017 May; 40(5):487-497.JE

Abstract

BACKGROUND

Visceral adiposity index (VAI) is a proposed parameter to evaluate visceral obesity instead of waist circumference (WC) in patients with polycystic ovary syndrome (PCOS). We aimed to evaluate VAI levels in overweight and/or obese, and non-obese PCOS patients and investigate the association between metabolic and inflammatory parameters.

METHODS

Seventy-six PCOS patients between 18 and 40, and 38 age- and BMI-matched controls were enrolled into the study. Both PCOS groups and controls were classified into two subgroups according to body mass index (BMI) <25 and ≥25 kg/m2.

RESULTS

In PCOS patients, waist/hip ratio (WHR) (p = 0.023), diastolic blood pressure (DBP) (p = 0.001), insulin (p = 0.011), homeostasis of model assessment (HOMA-IR) (p = 0.006) and uric acid (UA) (p = 0.002) were higher than controls. In overweight and/or obese PCOS group, DBP (p < 0.001), insulin (p = 0.002), HOMA-IR (p = 0.001), triglyceride (p = 0.015) and VAI (p = 0.031) were higher than overweight and/or obese controls. In non-obese PCOS group, WHR (p = 0.016), WC (p = 0.030), DBP (p = 0.010) and UA (p < 0.001) were higher than non-obese controls. Similar VAI levels were found in all PCOS and non-obese PCOS subgroups than peer controls. Overweight and/or obese PCOS group had higher VAI levels than non-obese PCOS group (p < 0.001). VAI levels were positively correlated with WHR, glucose, HOMA-IR, high-sensitive CRP and UA in PCOS group. In controls, VAI levels were positively correlated with WHR, insulin and HOMA-IR.

CONCLUSION

We found that VAI levels were higher in overweight and/or obese PCOS patients compared to peer controls and non-obese PCOS patients, and associated with some metabolic and inflammatory parameters.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Durmus U
Department of Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Meram Yeniyol, Meram, 42100, Konya, Turkey.
Duran C
Division of Endocrinology and Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Meram Yeniyol, Meram, 42100, Konya, Turkey. drcduran@gmail.com.
Ecirli S
Department of Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Meram Yeniyol, Meram, 42100, Konya, Turkey.

MeSH

AdiposityAdultBlood GlucoseBody Mass IndexFemaleFollow-Up StudiesHumansInflammationInflammation MediatorsInsulinInsulin ResistanceMaleObesity, AbdominalOverweightPolycystic Ovary SyndromePrognosisProspective StudiesWaist CircumferenceWaist-Hip RatioYoung Adult

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27838846

Citation

Durmus, U, et al. "Visceral Adiposity Index Levels in Overweight And/or Obese, and Non-obese Patients With Polycystic Ovary Syndrome and Its Relationship With Metabolic and Inflammatory Parameters." Journal of Endocrinological Investigation, vol. 40, no. 5, 2017, pp. 487-497.
Durmus U, Duran C, Ecirli S. Visceral adiposity index levels in overweight and/or obese, and non-obese patients with polycystic ovary syndrome and its relationship with metabolic and inflammatory parameters. J Endocrinol Invest. 2017;40(5):487-497.
Durmus, U., Duran, C., & Ecirli, S. (2017). Visceral adiposity index levels in overweight and/or obese, and non-obese patients with polycystic ovary syndrome and its relationship with metabolic and inflammatory parameters. Journal of Endocrinological Investigation, 40(5), 487-497. https://doi.org/10.1007/s40618-016-0582-x
Durmus U, Duran C, Ecirli S. Visceral Adiposity Index Levels in Overweight And/or Obese, and Non-obese Patients With Polycystic Ovary Syndrome and Its Relationship With Metabolic and Inflammatory Parameters. J Endocrinol Invest. 2017;40(5):487-497. PubMed PMID: 27838846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visceral adiposity index levels in overweight and/or obese, and non-obese patients with polycystic ovary syndrome and its relationship with metabolic and inflammatory parameters. AU - Durmus,U, AU - Duran,C, AU - Ecirli,S, Y1 - 2016/11/12/ PY - 2016/09/23/received PY - 2016/11/07/accepted PY - 2016/11/14/pubmed PY - 2017/8/23/medline PY - 2016/11/14/entrez KW - High-sensitive CRP KW - Insulin resistance KW - Polycystic ovary syndrome KW - Uric acid KW - Visceral adiposity index KW - Waist circumference SP - 487 EP - 497 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 40 IS - 5 N2 - BACKGROUND: Visceral adiposity index (VAI) is a proposed parameter to evaluate visceral obesity instead of waist circumference (WC) in patients with polycystic ovary syndrome (PCOS). We aimed to evaluate VAI levels in overweight and/or obese, and non-obese PCOS patients and investigate the association between metabolic and inflammatory parameters. METHODS: Seventy-six PCOS patients between 18 and 40, and 38 age- and BMI-matched controls were enrolled into the study. Both PCOS groups and controls were classified into two subgroups according to body mass index (BMI) <25 and ≥25 kg/m2. RESULTS: In PCOS patients, waist/hip ratio (WHR) (p = 0.023), diastolic blood pressure (DBP) (p = 0.001), insulin (p = 0.011), homeostasis of model assessment (HOMA-IR) (p = 0.006) and uric acid (UA) (p = 0.002) were higher than controls. In overweight and/or obese PCOS group, DBP (p < 0.001), insulin (p = 0.002), HOMA-IR (p = 0.001), triglyceride (p = 0.015) and VAI (p = 0.031) were higher than overweight and/or obese controls. In non-obese PCOS group, WHR (p = 0.016), WC (p = 0.030), DBP (p = 0.010) and UA (p < 0.001) were higher than non-obese controls. Similar VAI levels were found in all PCOS and non-obese PCOS subgroups than peer controls. Overweight and/or obese PCOS group had higher VAI levels than non-obese PCOS group (p < 0.001). VAI levels were positively correlated with WHR, glucose, HOMA-IR, high-sensitive CRP and UA in PCOS group. In controls, VAI levels were positively correlated with WHR, insulin and HOMA-IR. CONCLUSION: We found that VAI levels were higher in overweight and/or obese PCOS patients compared to peer controls and non-obese PCOS patients, and associated with some metabolic and inflammatory parameters. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/27838846/Visceral_adiposity_index_levels_in_overweight_and/or_obese_and_non_obese_patients_with_polycystic_ovary_syndrome_and_its_relationship_with_metabolic_and_inflammatory_parameters_ DB - PRIME DP - Unbound Medicine ER -