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Radioprotective effect of Zamzam (alkaline) water: A cytogenetic study.

Abstract

BACKGROUND

Radioprotectors are useful compounds to reduce radiation toxicity of normal cells. Many natural radioprotectors have antioxidant power and display fewer toxicity and side effects than the chemical ones. Alkaline waters such as Zamzam have antioxidant power potentially. This study aimed to investigate the radioprotective effect of Zamzam water in mice bone marrow exposed to gamma radiation by micronuclei test.

METHOD

Five study groups including control group which was fed by ordinary water, the second group was fed by Zamzam water, and radiation groups were received 2Gy gamma with ordinary and Zamzam water for 10 days and another for 20 days. The frequency of micronuclei and polychromatic erythrocytes to normochromatic erythrocytes ratio were calculated by micronuclei test.

RESULT

In the absence of radiation, no significant difference was found between Zamzam group and control in the number of micronuclei in normochromatic erythrocytes, micronuclei in polychromatic erythrocytes, and the polychromatic erythrocyte to polychromatic erythrocyte plus normochromatic erythrocyte ratio. But all of these indices were significantly different between irradiated and non-irradiated groups. The frequency of micronuclei in polychromatic erythrocytes was not significantly different between 10 and 20 days Zamzam irradiated groups, but the reduction in micronuclei in normochromatic erythrocytes and an increase in the polychromatic erythrocyte to polychromatic erythrocyte plus normochromatic erythrocyte ratio compared to ordinary water were seen in 20 days Zamzam group. Dose reduction factor was 1.36 and 2 for Zamzam water groups of 10 days and 20 days, respectively.

CONCLUSION

The results demonstrated that Zamzam alkaline water could reduce clastogenic and cytotoxic effects of gamma irradiation.

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  • Authors+Show Affiliations

    ,

    Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.

    ,

    Medical Physics Department, Babol University of Medical Sciences, Babol, Iran. Electronic address: Monfared_ali@yahoo.com.

    ,

    Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.

    ,

    Laboratory of Cytogenetics, Novin Medical Radiation Institute, Tehran, Iran.

    Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.

    Source

    MeSH

    Cell Nucleus
    DNA Damage
    Dose-Response Relationship, Radiation
    Erythrocytes
    Gamma Rays
    Hydrogen-Ion Concentration
    Micronucleus Tests
    Mineral Waters
    Mutagens
    Radiation Protection

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27839844