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Diagnosis and Management of Cirrhosis-Related Osteoporosis.
Biomed Res Int 2016; 2016:1423462BR

Abstract

Management of cirrhosis complications has greatly improved, increasing survival and quality of life of the patients. Despite that, some of these complications are still overlooked and scarcely treated, particularly those that are not related to the liver. This is the case of osteoporosis, the only cirrhosis complication that is not solved after liver transplantation, because bone loss often increases after immunosuppressant therapy. In this review, the definitions of bone conditions in cirrhotic patients are analyzed, focusing on the more common ones and on those that have the largest impact on this population. Risk factors, physiopathology, diagnosis, screening strategies, and treatment of osteoporosis in cirrhotic patients are discussed, presenting the more striking data on this issue. Therapies used for particular conditions, such as primary biliary cirrhosis and liver transplantation, are also presented.

Authors+Show Affiliations

Department of Internal Medicine, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Distrito de Rubião Jr., 18 608 917 Botucatu, SP, Brazil.Department of Internal Medicine, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Distrito de Rubião Jr., 18 608 917 Botucatu, SP, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27840821

Citation

Santos, Lívia Alves Amaral, and Fernando Gomes Romeiro. "Diagnosis and Management of Cirrhosis-Related Osteoporosis." BioMed Research International, vol. 2016, 2016, p. 1423462.
Santos LA, Romeiro FG. Diagnosis and Management of Cirrhosis-Related Osteoporosis. Biomed Res Int. 2016;2016:1423462.
Santos, L. A., & Romeiro, F. G. (2016). Diagnosis and Management of Cirrhosis-Related Osteoporosis. BioMed Research International, 2016, p. 1423462.
Santos LA, Romeiro FG. Diagnosis and Management of Cirrhosis-Related Osteoporosis. Biomed Res Int. 2016;2016:1423462. PubMed PMID: 27840821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and Management of Cirrhosis-Related Osteoporosis. AU - Santos,Lívia Alves Amaral, AU - Romeiro,Fernando Gomes, Y1 - 2016/10/20/ PY - 2016/07/09/received PY - 2016/10/03/accepted PY - 2016/11/15/entrez PY - 2016/11/15/pubmed PY - 2017/2/12/medline SP - 1423462 EP - 1423462 JF - BioMed research international JO - Biomed Res Int VL - 2016 N2 - Management of cirrhosis complications has greatly improved, increasing survival and quality of life of the patients. Despite that, some of these complications are still overlooked and scarcely treated, particularly those that are not related to the liver. This is the case of osteoporosis, the only cirrhosis complication that is not solved after liver transplantation, because bone loss often increases after immunosuppressant therapy. In this review, the definitions of bone conditions in cirrhotic patients are analyzed, focusing on the more common ones and on those that have the largest impact on this population. Risk factors, physiopathology, diagnosis, screening strategies, and treatment of osteoporosis in cirrhotic patients are discussed, presenting the more striking data on this issue. Therapies used for particular conditions, such as primary biliary cirrhosis and liver transplantation, are also presented. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/27840821/full_citation L2 - https://dx.doi.org/10.1155/2016/1423462 DB - PRIME DP - Unbound Medicine ER -