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Diagnosis and Management of Cirrhosis-Related Osteoporosis.

Abstract

Management of cirrhosis complications has greatly improved, increasing survival and quality of life of the patients. Despite that, some of these complications are still overlooked and scarcely treated, particularly those that are not related to the liver. This is the case of osteoporosis, the only cirrhosis complication that is not solved after liver transplantation, because bone loss often increases after immunosuppressant therapy. In this review, the definitions of bone conditions in cirrhotic patients are analyzed, focusing on the more common ones and on those that have the largest impact on this population. Risk factors, physiopathology, diagnosis, screening strategies, and treatment of osteoporosis in cirrhotic patients are discussed, presenting the more striking data on this issue. Therapies used for particular conditions, such as primary biliary cirrhosis and liver transplantation, are also presented.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Distrito de Rubião Jr., 18 608 917 Botucatu, SP, Brazil.

    Department of Internal Medicine, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Distrito de Rubião Jr., 18 608 917 Botucatu, SP, Brazil.

    Source

    BioMed research international 2016: 2016 pg 1423462

    MeSH

    Absorptiometry, Photon
    Bone Density Conservation Agents
    Calcium
    Dietary Supplements
    Diphosphonates
    Evidence-Based Medicine
    Female
    Hormone Replacement Therapy
    Humans
    Liver Cirrhosis
    Male
    Mass Screening
    Osteoporosis
    Treatment Outcome
    Vitamin D

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    27840821

    Citation

    Santos, Lívia Alves Amaral, and Fernando Gomes Romeiro. "Diagnosis and Management of Cirrhosis-Related Osteoporosis." BioMed Research International, vol. 2016, 2016, p. 1423462.
    Santos LA, Romeiro FG. Diagnosis and Management of Cirrhosis-Related Osteoporosis. Biomed Res Int. 2016;2016:1423462.
    Santos, L. A., & Romeiro, F. G. (2016). Diagnosis and Management of Cirrhosis-Related Osteoporosis. BioMed Research International, 2016, p. 1423462.
    Santos LA, Romeiro FG. Diagnosis and Management of Cirrhosis-Related Osteoporosis. Biomed Res Int. 2016;2016:1423462. PubMed PMID: 27840821.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diagnosis and Management of Cirrhosis-Related Osteoporosis. AU - Santos,Lívia Alves Amaral, AU - Romeiro,Fernando Gomes, Y1 - 2016/10/20/ PY - 2016/07/09/received PY - 2016/10/03/accepted PY - 2016/11/15/entrez PY - 2016/11/15/pubmed PY - 2017/2/12/medline SP - 1423462 EP - 1423462 JF - BioMed research international JO - Biomed Res Int VL - 2016 N2 - Management of cirrhosis complications has greatly improved, increasing survival and quality of life of the patients. Despite that, some of these complications are still overlooked and scarcely treated, particularly those that are not related to the liver. This is the case of osteoporosis, the only cirrhosis complication that is not solved after liver transplantation, because bone loss often increases after immunosuppressant therapy. In this review, the definitions of bone conditions in cirrhotic patients are analyzed, focusing on the more common ones and on those that have the largest impact on this population. Risk factors, physiopathology, diagnosis, screening strategies, and treatment of osteoporosis in cirrhotic patients are discussed, presenting the more striking data on this issue. Therapies used for particular conditions, such as primary biliary cirrhosis and liver transplantation, are also presented. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/27840821/full_citation L2 - https://dx.doi.org/10.1155/2016/1423462 DB - PRIME DP - Unbound Medicine ER -