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Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats.
Ren Fail. 2017 Nov; 39(1):130-139.RF

Abstract

This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with sitagliptin in experimentally induced diabetic nephropathy. The diabetic rats were treated with coenzyme Q10 or sitagliptin and their concomitant administration. Various parameters of renal function like serum creatinine, urea, uric acid and markers of oxidative stress such as renal malondialdehyde content (MDA), glutathione (GSH) level and superoxide dismutase (SOD), catalase activities were measured. TNF-α, TGF-β, MPO activity and nitrite content were estimated in renal tissue with histopathological observation. Diabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum creatinine, urea and uric acid levels. Streptozotocin-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and GSH level. In addition, TNF-α, TGF- β, MPO activity and nitrite content were significantly increased in diabetic rats. Treatment with coenzyme Q10 or sitagliptin and their co-administration ameliorated STZ-nicotinamide-induced renal damage which was reflected by decreased oxidative stress, TNF-α, TGF-β, MPO activity, nitrite content along with histopathological changes. To conclude, concomitant administration of coenzyme Q10 and sitagliptin showed a better renoprotective effect than coenzyme Q10 or sitagliptin when given alone.

Authors+Show Affiliations

a Department of Pharmacy , Sumandeep Vidyapeeth , Piparia , Vadodara , Gujarat , India.a Department of Pharmacy , Sumandeep Vidyapeeth , Piparia , Vadodara , Gujarat , India.a Department of Pharmacy , Sumandeep Vidyapeeth , Piparia , Vadodara , Gujarat , India.a Department of Pharmacy , Sumandeep Vidyapeeth , Piparia , Vadodara , Gujarat , India.a Department of Pharmacy , Sumandeep Vidyapeeth , Piparia , Vadodara , Gujarat , India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27841100

Citation

Maheshwari, Rajesh, et al. "Effect of Concomitant Administration of Coenzyme Q10 With Sitagliptin On Experimentally Induced Diabetic Nephropathy in Rats." Renal Failure, vol. 39, no. 1, 2017, pp. 130-139.
Maheshwari R, Balaraman R, Sen AK, et al. Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. Ren Fail. 2017;39(1):130-139.
Maheshwari, R., Balaraman, R., Sen, A. K., Shukla, D., & Seth, A. (2017). Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. Renal Failure, 39(1), 130-139. https://doi.org/10.1080/0886022X.2016.1254659
Maheshwari R, et al. Effect of Concomitant Administration of Coenzyme Q10 With Sitagliptin On Experimentally Induced Diabetic Nephropathy in Rats. Ren Fail. 2017;39(1):130-139. PubMed PMID: 27841100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. AU - Maheshwari,Rajesh, AU - Balaraman,Ramachandran, AU - Sen,Ashim Kumar, AU - Shukla,Disha, AU - Seth,Avinash, Y1 - 2016/11/13/ PY - 2016/11/15/pubmed PY - 2017/3/10/medline PY - 2016/11/15/entrez KW - Streptozotocin KW - TGF-β KW - TNF-α KW - coenzyme Q10 KW - diabetic nephropathy KW - sitagliptin SP - 130 EP - 139 JF - Renal failure JO - Ren Fail VL - 39 IS - 1 N2 - This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with sitagliptin in experimentally induced diabetic nephropathy. The diabetic rats were treated with coenzyme Q10 or sitagliptin and their concomitant administration. Various parameters of renal function like serum creatinine, urea, uric acid and markers of oxidative stress such as renal malondialdehyde content (MDA), glutathione (GSH) level and superoxide dismutase (SOD), catalase activities were measured. TNF-α, TGF-β, MPO activity and nitrite content were estimated in renal tissue with histopathological observation. Diabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum creatinine, urea and uric acid levels. Streptozotocin-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and GSH level. In addition, TNF-α, TGF- β, MPO activity and nitrite content were significantly increased in diabetic rats. Treatment with coenzyme Q10 or sitagliptin and their co-administration ameliorated STZ-nicotinamide-induced renal damage which was reflected by decreased oxidative stress, TNF-α, TGF-β, MPO activity, nitrite content along with histopathological changes. To conclude, concomitant administration of coenzyme Q10 and sitagliptin showed a better renoprotective effect than coenzyme Q10 or sitagliptin when given alone. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/27841100/Effect_of_concomitant_administration_of_coenzyme_Q10_with_sitagliptin_on_experimentally_induced_diabetic_nephropathy_in_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1254659 DB - PRIME DP - Unbound Medicine ER -