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Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press.
J Pharm Sci. 2017 01; 106(1):356-365.JP

Abstract

This study aims to investigate the influence of tablet punch head design on compaction and the resultant tablet mechanical properties. Tablets were prepared using flat-face punches with different head flat and head radius configurations, on a rotary tablet press with compression rolls of different diameters. The results showed that tablets produced using punches with head flats consistently displayed higher tensile strengths and lower capping tendencies. Exclusion of the head flat in the punch head geometry caused the compacts to undergo a state of continual deformation during the compaction cycle, possibly with increasing elasticity without the opportunity for more prolonged stress relaxation. Extension of head flat diameter produced small increments in dwell time and this could bring about significant improvements to the tablet mechanical quality. Changes to the punch head radius were found only to affect the compression profiles marginally, but this only produced insignificant differences in the tablet mechanical properties. A smaller compression roll allowed greater plastic flow during the dwell phase, but this was insufficient to effectively counteract the adverse effects due to increased strain rate during the consolidation phase, leading to deterioration of tablet mechanical quality.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Anbalagan P
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.
Sarkar S
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.
Liew CV
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.
Heng PWS
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore. Electronic address: phapaulh@nus.edu.sg.

MeSH

AcetaminophenAnalgesics, Non-NarcoticCompressive StrengthDrug CompoundingEquipment DesignExcipientsLactoseStarchStearic AcidsTabletsTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27842972

Citation

Anbalagan, Parthiban, et al. "Influence of the Punch Head Design On the Physical Quality of Tablets Produced in a Rotary Press." Journal of Pharmaceutical Sciences, vol. 106, no. 1, 2017, pp. 356-365.
Anbalagan P, Sarkar S, Liew CV, et al. Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press. J Pharm Sci. 2017;106(1):356-365.
Anbalagan, P., Sarkar, S., Liew, C. V., & Heng, P. W. S. (2017). Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press. Journal of Pharmaceutical Sciences, 106(1), 356-365. https://doi.org/10.1016/j.xphs.2016.10.016
Anbalagan P, et al. Influence of the Punch Head Design On the Physical Quality of Tablets Produced in a Rotary Press. J Pharm Sci. 2017;106(1):356-365. PubMed PMID: 27842972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press. AU - Anbalagan,Parthiban, AU - Sarkar,Srimanta, AU - Liew,Celine V, AU - Heng,Paul W S, Y1 - 2016/11/11/ PY - 2016/07/25/received PY - 2016/09/11/revised PY - 2016/10/11/accepted PY - 2016/11/16/pubmed PY - 2017/12/13/medline PY - 2016/11/16/entrez KW - capping KW - powder compaction KW - punch head KW - tablet compression tooling SP - 356 EP - 365 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 106 IS - 1 N2 - This study aims to investigate the influence of tablet punch head design on compaction and the resultant tablet mechanical properties. Tablets were prepared using flat-face punches with different head flat and head radius configurations, on a rotary tablet press with compression rolls of different diameters. The results showed that tablets produced using punches with head flats consistently displayed higher tensile strengths and lower capping tendencies. Exclusion of the head flat in the punch head geometry caused the compacts to undergo a state of continual deformation during the compaction cycle, possibly with increasing elasticity without the opportunity for more prolonged stress relaxation. Extension of head flat diameter produced small increments in dwell time and this could bring about significant improvements to the tablet mechanical quality. Changes to the punch head radius were found only to affect the compression profiles marginally, but this only produced insignificant differences in the tablet mechanical properties. A smaller compression roll allowed greater plastic flow during the dwell phase, but this was insufficient to effectively counteract the adverse effects due to increased strain rate during the consolidation phase, leading to deterioration of tablet mechanical quality. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/27842972/Influence_of_the_Punch_Head_Design_on_the_Physical_Quality_of_Tablets_Produced_in_a_Rotary_Press_ DB - PRIME DP - Unbound Medicine ER -