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The role of optical coherence tomography in Alzheimer's disease.
Int J Retina Vitreous. 2016; 2:24.IJ

Abstract

BACKGROUND

Alzheimer's disease (AD) is the most common cause of dementia and its incidence is increasing worldwide along with population aging. Previous clinical and histologic studies suggest that the neurodegenerative process, which affects the brain, may also affect the retina of AD patients.

MAIN BODY

Optical coherence tomography (OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Several previous studies demonstrated that both peripapillary retinal nerve fiber layer and macular thickness measurements assessed by OCT were able to detect neuronal loss in AD. Moreover, recent advances in OCT technology, have allowed substantial enhancement in ultrastructural evaluation of the macula, enabling the assessment not only of full-thickness retinal measurements but also of inner retinal layers, which seems to be a promising approach, mainly regarding the assessment of retinal ganglion cell layer impairment in AD patients. Furthermore, retinal neuronal loss seems to correlate with cognitive impairment in AD, reinforcing the promising role of OCT in the clinical evaluation of these patients.

CONCLUSION

The purpose of this article is to review the main findings on OCT in AD patients, to discuss the role of this important diagnostic tool in these patients and how OCT technology may be useful in understanding morphological retinal changes in AD.

Authors+Show Affiliations

Department of Ophthalmology, School of Medicine, Juiz de Fora Eye Hospital, Federal University of Juiz de Fora, Av. Barão do Rio Branco, 4051, Bom Pastor, Juiz de Fora, MG 36021-630 Brazil ; Juiz de Fora Eye Hospital, Juiz de Fora, MG Brazil.Department of Neurology, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.Juiz de Fora Eye Hospital, Juiz de Fora, MG Brazil.Juiz de Fora Eye Hospital, Juiz de Fora, MG Brazil.Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Pub Type(s)

Review
Journal Article

Language

eng

PubMed ID

27847642

Citation

Cunha, Leonardo Provetti, et al. "The Role of Optical Coherence Tomography in Alzheimer's Disease." International Journal of Retina and Vitreous, vol. 2, 2016, p. 24.
Cunha LP, Almeida AL, Costa-Cunha LV, et al. The role of optical coherence tomography in Alzheimer's disease. Int J Retina Vitreous. 2016;2:24.
Cunha, L. P., Almeida, A. L., Costa-Cunha, L. V., Costa, C. F., & Monteiro, M. L. (2016). The role of optical coherence tomography in Alzheimer's disease. International Journal of Retina and Vitreous, 2, 24.
Cunha LP, et al. The Role of Optical Coherence Tomography in Alzheimer's Disease. Int J Retina Vitreous. 2016;2:24. PubMed PMID: 27847642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of optical coherence tomography in Alzheimer's disease. AU - Cunha,Leonardo Provetti, AU - Almeida,Ana Laura Maciel, AU - Costa-Cunha,Luciana Virgínia Ferreira, AU - Costa,Carolina Ferreira, AU - Monteiro,Mário L R, Y1 - 2016/10/17/ PY - 2016/08/04/received PY - 2016/10/04/accepted PY - 2016/11/17/entrez PY - 2016/11/17/pubmed PY - 2016/11/17/medline KW - Alzheimer’s disease KW - Dementia KW - Ganglion cell layer KW - Macula KW - Mild cognitive impairment KW - Optic nerve KW - Optical coherence tomography KW - Retina KW - Retinal nerve fiber layer SP - 24 EP - 24 JF - International journal of retina and vitreous JO - Int J Retina Vitreous VL - 2 N2 - BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia and its incidence is increasing worldwide along with population aging. Previous clinical and histologic studies suggest that the neurodegenerative process, which affects the brain, may also affect the retina of AD patients. MAIN BODY: Optical coherence tomography (OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Several previous studies demonstrated that both peripapillary retinal nerve fiber layer and macular thickness measurements assessed by OCT were able to detect neuronal loss in AD. Moreover, recent advances in OCT technology, have allowed substantial enhancement in ultrastructural evaluation of the macula, enabling the assessment not only of full-thickness retinal measurements but also of inner retinal layers, which seems to be a promising approach, mainly regarding the assessment of retinal ganglion cell layer impairment in AD patients. Furthermore, retinal neuronal loss seems to correlate with cognitive impairment in AD, reinforcing the promising role of OCT in the clinical evaluation of these patients. CONCLUSION: The purpose of this article is to review the main findings on OCT in AD patients, to discuss the role of this important diagnostic tool in these patients and how OCT technology may be useful in understanding morphological retinal changes in AD. SN - 2056-9920 UR - https://www.unboundmedicine.com/medline/citation/27847642/The_role_of_optical_coherence_tomography_in_Alzheimer's_disease_ L2 - https://journalretinavitreous.biomedcentral.com/articles/10.1186/s40942-016-0049-4 DB - PRIME DP - Unbound Medicine ER -
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