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Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections.
Eur J Pharmacol. 2017 Aug 05; 808:8-13.EJ

Abstract

Recent years have seen the rise of invasive fungal infections, which are mostly due to the increase in patients. Three major opportunistic fungal species in human are Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans that pose the biggest concern for these immunocompromised patients' mortality. The growing occurrence of opportunistic fungal infections has sparked the interest to understand defense mechanisms against pathogenic fungi. Toll-like receptors (TLRs), as a part of innate immune system, play an important role for recognizing the invading microorganisms and initiating sufficient immune responses. Recent studies have revealed an integrated role for TLR, signaling inactivating immune defense mechanisms against exact fungi. Among TLRs, TLR2 and TLR4 are the major participants in fungi recognition. The present paper highlights the role of TLR participants in fungal recognition as well as their mechanisms.

Authors+Show Affiliations

Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: e.mortaz@uu.nl.Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Academic Center for Education, Culture and Research, Tehran Organization, Tehran, Iran.Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27851904

Citation

Taghavi, Mehdi, et al. "Role of Pathogen-associated Molecular Patterns (PAMPS) in Immune Responses to Fungal Infections." European Journal of Pharmacology, vol. 808, 2017, pp. 8-13.
Taghavi M, Khosravi A, Mortaz E, et al. Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections. Eur J Pharmacol. 2017;808:8-13.
Taghavi, M., Khosravi, A., Mortaz, E., Nikaein, D., & Athari, S. S. (2017). Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections. European Journal of Pharmacology, 808, 8-13. https://doi.org/10.1016/j.ejphar.2016.11.013
Taghavi M, et al. Role of Pathogen-associated Molecular Patterns (PAMPS) in Immune Responses to Fungal Infections. Eur J Pharmacol. 2017 Aug 5;808:8-13. PubMed PMID: 27851904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections. AU - Taghavi,Mehdi, AU - Khosravi,Alireza, AU - Mortaz,Esmaeil, AU - Nikaein,Donya, AU - Athari,Seyyed Shamsadin, Y1 - 2016/11/14/ PY - 2015/11/14/received PY - 2016/10/22/revised PY - 2016/11/08/accepted PY - 2016/11/17/pubmed PY - 2017/11/29/medline PY - 2016/11/17/entrez KW - Aspergillus fumigatus KW - Fungal infection KW - Innate immunity KW - Pathogen-associated molecular pattern KW - Toll-like receptors SP - 8 EP - 13 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 808 N2 - Recent years have seen the rise of invasive fungal infections, which are mostly due to the increase in patients. Three major opportunistic fungal species in human are Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans that pose the biggest concern for these immunocompromised patients' mortality. The growing occurrence of opportunistic fungal infections has sparked the interest to understand defense mechanisms against pathogenic fungi. Toll-like receptors (TLRs), as a part of innate immune system, play an important role for recognizing the invading microorganisms and initiating sufficient immune responses. Recent studies have revealed an integrated role for TLR, signaling inactivating immune defense mechanisms against exact fungi. Among TLRs, TLR2 and TLR4 are the major participants in fungi recognition. The present paper highlights the role of TLR participants in fungal recognition as well as their mechanisms. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/27851904/Role_of_pathogen_associated_molecular_patterns__PAMPS__in_immune_responses_to_fungal_infections_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(16)30706-3 DB - PRIME DP - Unbound Medicine ER -