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Recent developments in circulating biomarkers in Parkinson's disease: the potential use of miRNAs in a clinical setting.
Bioanalysis. 2016 Dec; 8(23):2497-2518.B

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 5% of the elderly population. PD diagnosis is still based on the identification of neuromotor symptoms although nonmotor manifestations emerge years prior to diagnosis. The discovery of biomarkers at the earliest stages of PD is of extreme interest. miRNAs have been considered potential biomarkers for neurodegenerative diseases, but only a limited number have been found to be PD related. This review focuses on the current findings in the field of circulating miRNAs in PD and the challenges surrounding clinical utility and validation. We briefly describe the more established circulating biomarkers in PD and provide a more thorough review of miRNAs differentially expressed in PD. We highlight their potential for being considered as biomarkers for diagnosis while emphasizing the challenges for adequate validation of the findings and how miRNAs can be envisioned in a clinical setting satisfying regulatory bodies.

Authors+Show Affiliations

Department of Non-Clinical Development, UCB Biopharma SPRL, Braine L'Alleud, Belgium.Department of Non-Clinical Development, UCB Biopharma SPRL, Braine L'Alleud, Belgium.Department of Non-Clinical Development, UCB Biopharma SPRL, Braine L'Alleud, Belgium.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27855513

Citation

Teixeira Dos Santos, Marcia Cristina, et al. "Recent Developments in Circulating Biomarkers in Parkinson's Disease: the Potential Use of miRNAs in a Clinical Setting." Bioanalysis, vol. 8, no. 23, 2016, pp. 2497-2518.
Teixeira Dos Santos MC, Bell R, da Costa AN. Recent developments in circulating biomarkers in Parkinson's disease: the potential use of miRNAs in a clinical setting. Bioanalysis. 2016;8(23):2497-2518.
Teixeira Dos Santos, M. C., Bell, R., & da Costa, A. N. (2016). Recent developments in circulating biomarkers in Parkinson's disease: the potential use of miRNAs in a clinical setting. Bioanalysis, 8(23), 2497-2518.
Teixeira Dos Santos MC, Bell R, da Costa AN. Recent Developments in Circulating Biomarkers in Parkinson's Disease: the Potential Use of miRNAs in a Clinical Setting. Bioanalysis. 2016;8(23):2497-2518. PubMed PMID: 27855513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent developments in circulating biomarkers in Parkinson's disease: the potential use of miRNAs in a clinical setting. AU - Teixeira Dos Santos,Marcia Cristina, AU - Bell,Rosie, AU - da Costa,Andre Nogueira, PY - 2016/11/19/entrez PY - 2016/11/20/pubmed PY - 2017/1/20/medline KW - Parkinson’s disease KW - biomarkers KW - early diagnosis KW - miRNA SP - 2497 EP - 2518 JF - Bioanalysis JO - Bioanalysis VL - 8 IS - 23 N2 - Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 5% of the elderly population. PD diagnosis is still based on the identification of neuromotor symptoms although nonmotor manifestations emerge years prior to diagnosis. The discovery of biomarkers at the earliest stages of PD is of extreme interest. miRNAs have been considered potential biomarkers for neurodegenerative diseases, but only a limited number have been found to be PD related. This review focuses on the current findings in the field of circulating miRNAs in PD and the challenges surrounding clinical utility and validation. We briefly describe the more established circulating biomarkers in PD and provide a more thorough review of miRNAs differentially expressed in PD. We highlight their potential for being considered as biomarkers for diagnosis while emphasizing the challenges for adequate validation of the findings and how miRNAs can be envisioned in a clinical setting satisfying regulatory bodies. SN - 1757-6199 UR - https://www.unboundmedicine.com/medline/citation/27855513/Recent_developments_in_circulating_biomarkers_in_Parkinson's_disease:_the_potential_use_of_miRNAs_in_a_clinical_setting_ L2 - https://www.future-science.com/doi/10.4155/bio-2016-0166?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -